Brain metastases
<p>Upfront whole brain radiotherapy for multiple brain metastases in patients with EGFR-mutant lung adenocarcinoma</p>
... extracranial metastases during brain metastases, whether the patients underwent any ...extracranial metastases (yes, no), and chemother- apy (yes, ...
11
Management of brain metastases: history and the present
... Brain metastases are significant causes of morbidity or mortality for patients with metastatic ...of brain metastases is ...for brain metastases evolved rapidly during the last ...
8
Immune response in breast cancer brain metastases and their microenvironment: the role of the PD 1/PD L axis
... in brain metasta- ses from various solid tumors and TIL density, and the au- thors also postulated that the density of CD3+, CD8+ and CD45RO+ TILs, and the calculated immunoscore, are posi- tively correlated with ...
11
Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer
... with brain metastases had completed prior cranial radiotherapy about 5, 11 and 70 weeks prior to the baseline PET scan (Table ...extra-cranial metastases and normal tissue within the field of view of ...
10
Comprehensive molecular biomarker identification in breast cancer brain metastases
... the brain metastatic pro- cess are complex and subject of several ...In brain and lung metastatic BC, COX2, EGFR, and HBEGF have been identified as promoting factors of extrava- sation through ...
20
Breast cancer subtypes and survival in patients with brain metastases
... the brain (4 months vs ...on brain metastases, several studies have shown a survival benefit with trastuzumab in HER2-positive patients with BM, who had a significantly longer survival time compared ...
8
Prolonged survival of patients with EGFR mutated non small cell lung cancer with solitary brain metastases treated with surgical resection of brain and lung lesions followed by EGFR TKIs
... BM: brain metastases; ECOG: Eastern Cooperative Oncology Group; EGFR: Epidermal growth factor receptor; GPA: Graded prognostic assessment; m + : Mutation-positive; NSCLC: Non-small cell lung cancer; OS: ...
5
Immunotherapy of brain metastases: breaking a “dogma”
... asymptomatic brain metasta- ses were treated: Cohort A included 39 patients who had not received any prior brain therapy ...tiple brain lesions or larger than 1 ...non-active brain metasta- ...
10
Stereotactic radiosurgery (SRS) in the modern management of patients with brain metastases
... distant brain control and survival, a meta-analysis (MAL) was performed by Tsao, Xu and Sahgal in 2012 ...distant brain control favoring adjuvant WBRT at ...distant brain control, a treatment effect ...
13
Pathologically confirmed brain metastases from primary uterine cervical tumors: two cases and a literature review
... the brain. Most brain metastases from CC have been reported to be poorly differentiated [27], and nonsquamous subtypes account for 32% or more cases of brain metastasis [7, 28], which is ...
8
Breast cancer brain metastases: the last frontier
... of brain metastases, which now poses a significant threat ...the brain parenchyma and develop brain ...without brain metastases, the ratio of trastuzumab in plasma to tras- ...
10
Grade III meningioma with gastro intestinal tract and brain metastases: case report and review of the literature
... Postoperative brain MRI showed hemorrhagic remodel- ing without any evidence of a residual tumor ...A brain MRI revealed a local recurrence and six new brain lesions ...anoma brain ...
8
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
... [4–7]. Brain metastases (BM) are the most common intracranial tumors in adults being al- most up to ten-fold more common than primary brain tumors and some primary tumors, among others BC, ex- hibit ...
21
Activity of cabozantinib in radioresistant brain metastases from renal cell carcinoma: two case reports
... 2]. Metastases often occur in the 2 to 5 years fol- lowing surgery but are uncommon at initial ...diagnosis. Metastases are frequently located in lungs and lymph nodes, but also in bones and liver; ...
6
Blood-brain barrier permeability of gefitinib in patients with brain metastases from non-small-cell lung cancer before and during whole brain radiation therapy
... of different durations. The relationships between CSF and serum concentrations of gefetinib were determined by linear regression. The survival curves were generated using the Kaplan–Meier method. Univariate analysis of ...
11
BRAF inhibitors and radiotherapy for melanoma brain metastases: potential advantages and disadvantages of combination therapy
... the brain, resulting in rapid deterioration in both quality and quantity of ...melanoma brain metastases (MBM) have predominantly consisted of surgery and ...
11
A BRCA1deficient like signature is enriched in breast cancer brain metastases and predicts DNA damage induced poly (ADP ribose) polymerase inhibitor sensitivity
... cancer brain metastases from HER2+ pri- mary tumors that did not metastasize to the brain, we performed a comparative gene expression analysis be- tween 19 brain metastasis specimens from ...
10
Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial
... There remains a critical need for therapeutic interven- tions that prolong patient survival and maintain or improve QoL of patients with breast cancer and brain metastases. Despite the relatively small ...
13
A Rare Occurrence of Isolated Brain Metastases from Gastric Cancer
... extracranial metastases (50% vs 78.2%) and fewer cases with multiple brain metastases (29% vs ...extracranial metastases and multiple brain ...
6
Clinical data from the real world: efficacy of Crizotinib in Chinese patients with advanced ALK-rearranged non-small cell lung cancer and brain metastases
... baseline brain metastases at the initiation of Crizotinib ...of brain metastases development, patient ECOG PS was 0 ...the brain metastases, 12 patients received local treatment ...
9