BRCA 1
Risk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers
... Our study tries to address this problem using the standard methodology of meta-analysis, and formally assessing the presence and sources of heterogeneity in the results of the available studies. After the publication of ...
6
To Study the Immunohistochemical expression of BRCA 1 in breast cancer and to assess its association with expression of ER, PR and HER 2 receptors
... BRCA 1 located on chromosome 17 is found to be mutated in many familial breast and ovarian ...gene. BRCA 1 has A growth regulatory function of breast epithelial ...a BRCA 1 ...
112
The Narratives of Young Women with BRCA 1/2 Gene Mutation: A Qualitative Analysis
... that BRCA runs in her family. “When I heard my dad had BRCA 1, I just don’t think I knew what it ...the BRCA gene, she didn’t have a strong ...about BRCA “in passing,” as a result of ...
158
Therapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel
... metastases showed progression. The treatment failure was the reason to analyze the tumor-DNA for molecular alterations using two panels of 14 genes including BRCA 1 and BRCA 2 (452 amplicons in ...
7
Reasons for Prophylactic Mastectomy in Women Carrying BRCA 1/2 Mutation: A Systematic Literature Review
... with BRCA 1 and BRCA 2 mutations. Women with BRCA 1 or BRCA 2 mutation present up to 95% increased risk of breast cancer and are advised to take preventive ...questions: ...
9
Design and synthesis of two steroid derivatives from 2-nitroestrone and theoretical evaluation of their interaction with BRCA-1
... with BRCA-1 protein surface using a docking ...of BRCA-1 protein as compared to 8; this phenomenon, may exert changes in the biological activity of BRCA-1 ...
20
BRCA 1 and BRCA 2: Role in Breast Cancer
... IJSRR, 8(1) Jan. – Mar., 2019 Page 2223 mammary epithelial cell growth. This suggestion is consistent with the observation that the murine homologue of BRCA1 is widely expressed in proliferating and ...
11
Transferring embryos with indeterminate PGD results: the ethical implications
... There was also significant debate about how to define the appropriateness of transfer of indeterminate embryos when considering different diseases. For example, mem- bers seemed to voice stronger opinions against ...
6
Original Article Overexpression of BRCA1 attenuates the sensitivity of PC9 cells to gefitinib
... gene 1 (BRCA1) is associated with chemoresistance and reduced survival following ...with BRCA-1 ...of BRCA-1 overexpressed PC-9 cells was significantly lower than that of the ...
8
Targeting of prostate specific membrane antigen for radio ligand therapy of triple negative breast cancer
... Development of prostate-specific membrane antigen (PSMA) addressing small molecules initiated applica- tion of their radiolabeled derivatives for theranostics of prostate cancer (PrCa) [1]. Gene expression ...
11
P53, KI67, Brca1 and brca 2 genes over expression in paraffin embedded primary breast cancer tissues of an indigenous black population: a 5years retrospective study
... though BRCA 2 phenotype is currently not fully established. In this study BRCA 1 over express immunostain positive tumors exhibited higher degree of estrogen receptor, progesterone and epidermal ...
6
Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition
... a BRCA mutation is neither necessary nor sufficient for patients to benefit from PARPi therapy, suggesting that PARP inhibitors may have additional mechanisms of action ...in BRCA in- tact ovarian cancer ...
14
Profile of olaparib in the treatment of advanced ovarian cancer
... germline BRCA mutations who have been treated with three or more prior lines of ...in BRCA 1/2 using whole blood specimens. PARP 1/2 enzymes repair single-stranded DNA breaks through base ...
5
<p>First-Line Treatment with Olaparib for Early Stage BRCA-Positive Ovarian Cancer: May It Be Possible? Hypothesis Potentially Generating a Line of Research</p>
... a better prognosis compared to the advanced setting, up to 40 – 50% of ESOC patients relapse. 8,9 Such as it concerns molecular characteristics of these tumors about 50% of high-grade serous ovarian carcinomas (HGSOC) ...
11
Identification of Novel Epstein-Barr Virus MicroRNA Genes from Nasopharyngeal Carcinomas
... of BRCA-1 with E6 and E7 reverses the inhibition of expression of estrogen receptor alpha ...by BRCA-1 is overcome through interaction with hypophosphorylated pRB ...of BRCA-1 in ...
9
Gene expression and mutation guided synthetic lethality eradicates proliferating and quiescent leukemia cells
... mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinase–mediated (DNA- PK–mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by poly(ADP)ribose polymerase ...
16
Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early onset breast cancer patients
... We have analyzed germline TP53 mutations in the remaining 83 individuals who tested negative for both BRCA1 and BRCA2 mutations (Table 1). Of these patients, 4 (4.8%) had a family history of at least one case of ...
8
RNF4 mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway
... Figure 1. Atypical clinical presentation of a patient with FA reveals a unique mutation in the FANCA gene that disrupts FAAP20 binding. (A) Image and quantification of chromosomal aberrations and radial ...
11
The first Japanese nationwide multicenter study of BRCA mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of BRCA (CHARLOTTE)
... FIGO stages showed a general increasing pattern in the prev- alence of gBRCA mutations. The prevalence of gBRCA mutations in patients diagnosed with FIGO stage I was 3.4% compared with 20.0% in those with FIGO IV (Table ...
7
BRCA mutation screening and patterns among high-risk Lebanese subjects
... The Lebanese population has limited access to clinical genetics specialists and information regarding genetic testing is usually delivered by other health-care profes- sionals such as oncologists [4]. The Manchester ...
7