Breast Cancer Stem Cells
Effects of miRNAs on functions of breast cancer stem cells and treatment of breast cancer
... Abstract: Breast cancer is one of the most common malignancies for women, which accounts for 30% of all female ...of breast cancer stem cells (BCSCs) is attributed to the ...
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Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations
... Abstract: Breast cancer is a leading cause of death in women, and almost all complications are due to chemotherapy ...Drug-resistant cells with stem cell phenotypes are thought to cause ...
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Evaluation of Breast Cancer Stem Cells and Intratumor Stemness Heterogeneity in Triple-negative Breast Cancer as Prognostic Factors
... that breast cancer stem cells (BCSCs), which possess the capacity for self-renewal and differentiation, are responsible for tumor initiation, proliferation and progression ...between ...
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NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells
... in cancer cell metastasis and the maintenance of cancer stem ...for breast cancer in particular, an association between NOTCH1 levels and metastasis has not been ...the cancer ...
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Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor
... Breast cancer (BC) is a serious disease to threat lives of ...from cancer stem cells ...identify breast cancer stem cells (BCSCs) in solid ...desired ...
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Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells
... targeting breast cancer stem cells (BCSCs) is important because these cells are regarded as culprit of breast cancer ...MCF-7 breast cancer cells in ...
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Identification of genes involved in breast cancer and breast cancer stem cells
... Abstract: Breast cancer is the most frequent type of cancer in ...of cancer stem cells (CSCs), which have the ability to self-renew and differentiate into multiple malignant cell ...
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Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly
... Rationale: Cancer stem cells (CSCs) have been implicated as the seeds of therapeutic resistance and metastasis, due to their unique abilities of self-renew, wide differentiation potentials and ...
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Breast cancer, stem cells and prospects for therapy
... The spectacular success of the tyrosine kinase inhibitor imatinib in chronic myeloid leukaemia provides a prototype for targeted therapeutics. While these therapeutics can induce dramatic tumour regression even in ...
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Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
... progression in preclinical models [55]. Besides, Galuni- sertib has acceptable tolerability and safety in advanced cancer patients (NCT01722825). In advanced hepato- cellular carcinoma (HCC), patients treated with ...
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MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell
... Background: One of the major obstacles in the treatment of breast cancer is breast cancer stem cells (BCSC) which are resistant to standard chemotherapeutic drugs. It has been ...
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Downregulation of CD44 reduces doxorubicin resistance of CD44<sup>+</sup>CD24<sup>-</sup> breast cancer cells
... a breast cancer stem cell population explained the minimal efficiency and high recurrence of conventional breast cancer treatments; breast cancer stem cells ...
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Isolate and identified cancer stem cells by using MCF7 human breast cancer cell line, using mammospheres formation in two different methods
... of cancer will allow scientists to develop an active target therapy of cancer ...many cells that have the ability to rapidly reproduce many more new cells and increase the ...tumour. ...
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Stem cell technology in breast cancer: current status and potential applications
... Abstract: Breast cancer, the leading cause of cancer among females, is supported by the presence of a rare subset of undifferentiated cells within the tumor, identified as breast ...
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Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells
... in cancer stem cells, a guide RNA (gRNA) (5′-GGGGCG GCGGGGGGGGCGGC-3′) was cloned into pHBCas9/gRNA-Pure vector (Hanheng Bio- technology, ...or breast cancer stem cells ...
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Oncolytic vaccinia virus GLV 1h68 strain shows enhanced replication in human breast cancer stem like cells in comparison to breast cancer cells
... GI-101A cells resulted in cell population with CD44 + CD24 + ESA + and CD44 + CD24 - ESA + markers We examined whether the treatment of GI-101A cell line with TGF-β1, similar to HMLE cell line [13,14], would lead ...
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Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
... the cancer stem cells, we decided to use mammosphere culture that was first used to isolate and expand mammary stem/pro- genitor cells by Dontu and colleagues [18], based on the ability ...
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Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages
... and breast cancer ...in breast tumor bearing mice by using BLI, and found that the development of tumors was inhibited by ZA ...of breast cancer in ...
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Role of cancer stem cells in breast and prostate cancer
... the stem cell niche there is a cellular hierarchy based on the morphology, proliferation and differentiation potential of the cells and the clones of cells formed in the hierarchy are known as: ...
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Breast cancer stromal fibroblasts promote the generation of CD44+CD24- cells through SDF-1/CXCR4 interaction
... stromal cells, including fibroblasts and endothelial cells ...epithelial cells derived from different donors do not express CXCR4 mRNA ...adult stem cells, which can be chemoat- tracted ...
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