Brugia malayi
The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models
... TLR2 and its co-receptor TLR6 have also been found to play a role in disease pathogenesis during infection with the filarial parasite, Brugia malayi, which causes lymphatic filariasis. In this setting, TLR2 ...
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Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo
... Functional analysis was carried out for differentially expressed wBm and Bm genes to identify overrepre- sented pathways using the Kyoto Encyclopedia of Genes and Genomes (KEGG v.43) [45]. For each query, the top match ...
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Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner
... Brugia malayi causes the human tropical disease, lymphatic ...B. malayi Mf can, directly adhere to vascular endothelial cells under static conditions and under flow conditions, they can bind at high ...
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In vitro gene silencing of independent phosphoglycerate mutase (iPGM) in the filarial parasite Brugia malayi
... 6. Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway ...
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Humans from Wuchereria bancrofti endemic area elicit substantial immune response to proteins of the filarial parasite Brugia malayi and its endosymbiont Wolbachia
... killing and correlated with their profound immunopro- phylactic efficacy [26]. Enhanced proliferative response of Bm-TPP, BmAF-Myo and wBm-LigA suggested the role of these proteins in inducing cellular immune re- sponse; ...
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Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3 dependent manner
... Brugia malayi causes the human tropical disease, lymphatic ...B. malayi Mf can, directly adhere to vascular endothelial cells under static conditions and under flow conditions, they can bind at high ...
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RNA interference mediated knockdown of Brugia malayi UDP Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae
... Lymphatic filariasis (LF) is a vector-borne, painful and disfiguring parasitic disease caused by Wuchereria ban- crofti, Brugia malayi and Brugia timori, leading to severe socio-economic ...
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Homologs of the Caenorhabditis elegans Masculinizing Gene her-1 in C. briggsae and the Filarial Parasite Brugia malayi
... The masculinizing gene her-1 in Caenorhabditis elegans (Ce-her-1) encodes a novel protein, HER-1A, which is required for male development. To identify conserved elements in her-1 we have cloned and characterized two ...
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Isolation, amplification and sequence analysis of the gene encoding Enolase from lymphatic filarial parasite Brugia malayi
... by Brugia malayi, commonly known as elephantiasis, is a neglected tropical ...B. malayi was isolated, amplified and identified by ...B. malayi to amplify the cDNA of ...B. malayi was ...
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IN SILICO SCREENING OF FLAVONOLS AGAINST BRUGIA MALAYI ASPARAGINYL tRNA SYNTHETASE
... INTRODUCTION: Lymphatic Filariasis (LF) is one of the most abandoned tropical diseases in several countries. It leads to major health problems such as physical disability, chronic morbidity and disfiguring 1 . It is ...
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Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus
... Bioinformatic analysis of wBm genome using three dis- tinct databases consistently identified only two lipoproteins [7]: 1) Wolbachia peptidoglycan-associated lipoprotein (wBmPAL) and 2) Wolbachia VirB6 (wBmVirB6), which ...
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Screening of Phyto- molecules against Brugia malayi asparaginyl tRNA synthetase - An in silico approach towards anti filarial leads
... Lymphatic Filariasis is one of the most neglected tropical diseases caused by Brugia malayi. The existing classical drugs act mostly on the larval stages of the parasite. The target Asparaginyl tRNA ...
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Pulmonary Inflammation Induced by a Recombinant Brugia malayi γ-glutamyl transpeptidase Homolog: Involvement of Humoral Autoimmune Responses
... B. malayi allergen in patients with acute TPE as a homolog of human -GT with the poten- tial to induce autoreactivity against pulmonary ep- ...B. malayi -GT **** recognized and bound strongly to the apical ...
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Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi
... Quantitative RT-PCR (qRT-PCR) was used to validate the publicly available RNA-Seq data using RNA provided by the NIAID FR3 Resource Center. Reverse transcrip- tion was carried out using the QuantiTect Reverse Tran- ...
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Real time PCR detection of the HhaI tandem DNA repeat in pre and post patent Brugia malayi infections: a study in Indonesian transmigrants
... B. malayi animal model and a unique sample set from an Indo- nesian transmigrant population with a known history of time spent in an endemic ...detecting Brugia DNA in pre-patent amicrofilaremic animals, ...
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Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B malayi infective larvae
... Cystatins or cysteine protease inhibitors (CPIs) have been described across the animal and plant kingdoms. The role of CPIs in parasitic nematodes has been attrib- uted to essential developmental processes and to ...
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Preadult Stage Parasites and Multiple Timed Exposure to Infective Larvae Are Involved in Development of Limb Edema in Brugia malayi-Infected Indian Leaf Monkeys (Presbytis entellus)
... Animals. Young adult male Indian leaf monkeys (P. entellus), commonly known in Hindi as langur, 3 to 4 kg in body weight were obtained from local suppliers. Immediately on receipt, the animals were kept in quarantine for ...
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Brugia malayi Antigen (BmA) inhibits HIV-1 trans-infection but neither BmA nor ES-62 alter HIV-1 infectivity of DC induced CD4+ Th-cells
... One of the hallmarks of HIV-1 disease is the association of heightened CD4 + T-cell activa- tion with HIV-1 replication. Parasitic helminths including filarial nematodes have evolved numerous and complex mechanisms to ...
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Immune responses of Aedes togoi, Anopheles paraliae and Anopheles lesteri against nocturnally subperiodic Brugia malayi microfilariae during migration from the midgut to the site of development
... B. malayi mf Infected adult females of ...B. malayi from the midgut (ingested), haemocoel and thoracic muscle fibres of each mosquito species were counted at different time ...
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Susceptibility of eight species members in the Anopheles hyrcanus group to nocturnally subperiodic Brugia malayi
... So far, at least two physiological races of B. malayi, i.e., nocturnally subperiodic and diurnally subperiodic have been discerned in southern Thailand. The nocturnally sub- periodic race is located in endemic ...
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