BSEP/Bsep
Original Article Glucocorticoids alleviates lipopolysaccharide-induced acute liver injury associated with promoting the expression of NTCP and BSEP
... and BSEP were upregulated by MP treat- ment in the livers of LPS-induced sepsis ...of BSEP was significantly increased in livers of LPS- induced mice treated with MP at the dose of 2 mg/kg, which was not ...
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Original Article Enhancement of interaction of BSEP and HAX-1 on the canalicular membrane of hepatocytes in a mouse model of cholesterol cholelithiasis
... recorded. BSEP, PKCα and phospho-PKCα expression was examined by immunoblotting as- ...of BSEP and HAX-1 was studied by immunofluorescent microscopy and ...group, BSEP levels on the cana- licular ...
7
kfv231.pdf
... via BSEP is the rate-limiting step in bile acid transport and an important determinant of bile flow (Kullak-Ublick et ...of BSEP may lead to accumulation of bile acids within hepatocytes and subsequently ...
14
Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2
... of BSEP inversely correlates with the severity of the patient ’ s ...of BSEP activity is associated with progressive familial intrahepatic cholestasis type 2 ...
9
Analysing the Need of Communication to Improve Black Sea Fisheries Management Policies in the Riparian Countries
... In near future, there will be a great risk as to collapse of fragile stocks due to inefficient national management policies and insufficient legal measures. There is an urgent need to temporary or permanent limitations ...
11
<p>The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease</p>
... To assess the level of gene expression of tight junction protein- 1 (ZO-1), occludin, TNF- α , interleukin-1 β (IL-1 β ), IL-10, fi broblast growth factor 15 (Fgf15), cholesterol 7 α - hydroxylase (CYP7A1), sterol 12 α ...
22
Pioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet
... Pioglitazone, a thiazoledinedione (TZD), is a highly se- lective peroxisome proliferator-activated receptor-γ (PPARγ) agonist. Widely used as antidiabetic agent, pio- glitazone not only has an impact on glycemic control ...
11
Atovaquone and quinine anti malarials inhibit ATP binding cassette transporter activity
... Abbreviations ABC transporter: ATP binding cassette transporter; P-gp: P-glycoprotein; BCRP: Breast cancer resistance protein; BSEP: Bile salt export protein; MRP: Multidrug resistance-a[r] ...
8
Beyond an Obvious Cause of Cholestasis in a Toddler: Compound Heterozygosity for ABCB11 Mutations
... That BSEP was expressed was consonant with age at presentation with icterus because the absence of BSEP expression characterizes PFIC2, which manifests in ...
8
The European Union and the South Caucasus; Three Perspectives on the Future of the European Project from the Caucasus. Europe in Dialogue 2009/1
... Europe in Dialogue 2009/01 Abbreviations AP Action Plan ACSE Armenian Civil Society Experts BSEC Black Sea Economic Cooperation BSEP Black Sea Environmental Program Blackseafor Black Sea[r] ...
140
The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II
... human BSEP gene that have previously been associated with PFIC ...in BSEP essential for its function or ...patients BSEP was not detected by immunohistochemistry ...affects BSEP function), the ...
9
Pancreatic adenocarcinoma in type 2 progressive familial intrahepatic cholestasis
... The hypothesis most likely explaining the develop- ment of pancreatic adenocarcinoma in our patient involves BSEP itself. BSEP may act as a tumor suppres- sor gene, and its malfunction may predispose to ...
5
Ferslew_unc_0153D_14873.pdf
... of BSEP in patients with PFIC type 1 has been ...encoding BSEP and phospholipid translocase (MDR3), respectively. Mutations in BSEP that are associated with decreased bile acid secretion lead to ...
194
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra and extrahepatic cholestasis
... namely, BSEP and MRP2 (11, ...and BSEP expression is critical in this process (45, ...the BSEP gene have been identified in the human population, and inactivating mutations give rise to PFIC2 ...of ...
11
Progressive familial intrahepatic cholestasis
... The first type, called PFIC1 (Byler disease) is caused by mutations in the ATP8B1 gene (also designated FIC1) [6,12]. This gene, which encodes a P-type ATPase, is located on human chromosome 18 and is also mutated in the ...
12
Yang_unc_0153D_14355.pdf
... In previous sections, direct and indirect mechanisms of drug-induced cholestasis mediated by interruption of bile acid homeostasis were reviewed. Since multiple processes are involved in bile acid homeostasis, an ...
327
Multidrug resistance associated protein 4 is a bile transporter of Clonorchis sinensis simulated by in silico docking
... TIFF 2938 kb Abbreviations 5′-RACE: 5′-rapid amplification of the cDNA ends; aa: Amino acid; ABC: ATP-binding cassette; BSEP: Bile salts export pump; CA: Cholic acid; CDCA: Chenodeoxycho[r] ...
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