Bunyamwera virus
Evolution of the Bunyamwera Virus Polymerase To Accommodate Deletions within Genomic Untranslated Region Sequences
... the virus life cycle and provide signals for encapsidation by nucleocapsid protein and the promoters for RNA transcription and replica- tion as well as for mRNA transcription ...bunyavirus, Bunyamwera ...
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Homotypic Interaction of Bunyamwera Virus Nucleocapsid Protein
... 19. Kaukinen, P., V. Kumar, K. Tulimaki, P. Engelhardt, A. Vaheri, and A. Plyusnin. 2004. Oligomerization of hantavirus N protein: C-terminal alpha- FIG. 5. Functional analysis of C-terminal deletion and double mutants ...
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RNA Binding Properties of Bunyamwera Virus Nucleocapsid Protein and Selective Binding to an Element in the 5′ Terminus of the Negative-Sense S Segment
... of Bunyamwera virus (BUN) (family Bunyaviridae, genus Bunyavirus) comprises three negative- sense RNA segments which act as transcriptional templates for the viral polymerase only when encapsidated by the ...
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Expression of functional Bunyamwera virus L protein by recombinant vaccinia viruses.
... The N protein was detected in cells expressing L protein from vaccinia viruses and transfected with Bunyamwera virus nucleocapsids lanes 2 and 3 but not in cells infected with vTF7-3 alo[r] ...
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Key Golgi Factors for Structural and Functional Maturation of Bunyamwera Virus
... of Bunyamwera virus in cells with impaired glyco- sylation ...specific virus and the cell line used ...the virus was grown in the presence of megalomycin, a trans-Golgi-disrupting drug (5) ...
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Activation of PKR by Bunyamwera Virus Is Independent of the Viral Interferon Antagonist NSs
... of Bunyamwera virus (BUNV), the prototype of the family Bunyaviridae, as a virulence factor that blocks the induction of IFN by ...recombinant virus that does not express NSs (BUNdelNSs ...
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Bunyamwera Virus Replication in Cultured Aedes albopictus (Mosquito) Cells: Establishment of a Persistent Viral Infection
... In this report, the replication of BUN in 1015 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Bunyamwera virus replication was examined in Aedes albopictus mosquito ce[r] ...
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Polymorphism and Structural Maturation of Bunyamwera Virus in Golgi and Post-Golgi Compartments
... different Bunyamwera virus-related structures were closer to “native” assemblies after freeze-substitution ...lular virus presents a single morphology ...
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Characterization of Bunyamwera virus S RNA that is transcribed and replicated by the L protein expressed from recombinant vaccinia virus.
... In contrast to the authentic Bunyamwera virus mRNA primers, which are G+C rich, the S RNAs made by the L protein in recombinant vaccinia virus-infected cells contain primer sequences whi[r] ...
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Role of N-Linked Glycans on Bunyamwera Virus Glycoproteins in Intracellular Trafficking, Protein Folding, and Virus Infectivity
... of Bunyamwera virus (BUN, family Bunyaviridae) contain three potential sites for the attachment of N-linked glycans: one site (N60) on Gn and two (N624 and N1169) on ...and virus replication were ...
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The Bunyamwera Virus mRNA Transcription Signal Resides within both the 3′ and the 5′ Terminal Regions and Allows Ambisense Transcription from a Model RNA Segment
... Bunyamwera virus (BUNV) is the prototype of the Bunyaviridae family of RNA viruses. BUNV genomic strands are templates for both replication and transcription, whereas the antigenomic RNAs serve only as ...
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Role of the Conserved Nucleotide Mismatch within 3′- and 5′-Terminal Regions of Bunyamwera Virus in Signaling Transcription
... Bunyamwera virus (BUNV) is the prototype of the Bunyaviridae family of tri-partite negative-sense RNA vi- ruses. The three BUNV segments possess 3 ⴕ and 5 ⴕ nontranslated regions (NTRs) that signal two RNA ...
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Bunyamwera Orthobunyavirus S-Segment Untranslated Regions Mediate Poly(A) Tail-Independent Translation
... of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family, possess a 5 ⴕ cap structure but lack a 3 ⴕ poly(A) tail, a common feature of eukaryotic mRNAs that greatly enhances translation ...model ...
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Visualizing the Replication Cycle of Bunyamwera Orthobunyavirus Expressing Fluorescent Protein-Tagged Gc Glycoprotein
... of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family and also of the Orthobunyavirus genus, are encoded by the medium (M) RNA genome segment and are involved in both viral attachment and ...
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Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/Beta Interferon
... virulence. Bunyamwera virus (BUN) is the prototype of the Bunyaviridae ...recombinant virus lacking the nonstructural protein NSs (BUN- delNSs) and showed that NSs is a nonessential gene product that ...
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Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein
... of virus replication, and assembly and budding occurring at membranes of the Golgi complex (Elliott et ...2005). Bunyamwera virus (BUNV) is the prototype of both the family Bunyaviridae and the genus ...
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Mutational Analyses of the Nonconserved Sequences in the Bunyamwera Orthobunyavirus S Segment Untranslated Regions
... Bunyamwera virus (BUNV) is the prototype of the genus Orthobunyavirus and the family ...recombinant virus but did not specifically affect levels of S segment RNAs or the encoded nucleocapsid ...
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Role of the Cytoplasmic Tail Domains of Bunyamwera Orthobunyavirus Glycoproteins Gn and Gc in Virus Assembly and Morphogenesis
... of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family, encodes a precursor polyprotein that is proteolytically cleaved to yield two structural proteins, Gn and Gc, and a nonstructural protein ...
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Mutational Analysis of the Bunyamwera Orthobunyavirus Nucleocapsid Protein Gene
... The bunyavirus nucleocapsid protein, N, is a multifunctional protein that encapsidates each of the three negative-sense genome segments to form ribonucleoprotein complexes that are the functional templates for viral ...
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The N terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism
... Bunyamwera virus (BUNV) is the type species of both the genus Orthobunyavirus and the family Bunyaviridae, members of which are important human pathogens causing diseases such as febrile illness and ...
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