Burst release.
FORMULATION AND EVALUATION OF BILAYER TABLETS OF BACLOFEN USING SYNTHETIC POLYMERS
... vitro release studies demonstrated that the release of Baclofen from the prepared bi-layer matrix tablets were dependent on polymeric ...sustained release polymers drug release was retarded up ...
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“PREPARATION AND EVALUATION OF ONCE A WEEKLY BIODEGRADABLE MICROSPHERE CONTAINING A BIOLOGICALLY ACTIVE AGENT BY THE SOLVENT EVAPORATION TECHNIQUE” by Vivek Patel*, Jayvadan Patel, Dhara Patel, India.
... “burst release” were prepared by the single emulsion- solvent evaporation method, and they could be readily suspended in appropriate medium for SC ...drug release properties and improved patient ...
6
Polymer-Based Nanofibers Impregnated with Drug Infused Plant Virus Particles as a Responsive Fabric for Therapeutic Delivery.
... sustained release at an effective drug ...zero-order release implant (A) that releases the drug at constant rate, toxic level of the drug that kills cancerous cells may take too long to ...rapid ...
145
pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin
... the burst release of insulin from PLGA nanoparticles and deliver insulin to specific gastrointestinal regions, hence to enhance bioavailability of insulin, the PLGA nanoparticles were further encapsulated ...
10
Sequential release of salidroside and paeonol from a nanosphere-hydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skin
... rapid release of salidroside from the hydrogel followed by sustained release of paeonol from the nanosphere was ...the burst release of salidroside from the hydrogel may enable prompt ...
12
Drug eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection
... drug release characteristics of TNT-Ti wires were evaluated, showing a two-phase release, with a burst release (37%) and a slow release with zero-order kinetics over 11 ...
6
Journal of Applied Pharmaceutical Science
... and burst manner within a short time period immediately after a programmable lag phase (Geest et ...delayed burst release can also be utilized for enhancing absorption, reducing side effects, ...
11
Inhibition of interleukin 1beta stimulated dedifferentiation of chondrocytes via controlled release of CrmA from hyaluronic acid chitosan microspheres
... the release kinetics of CrmA were characterized by an initial burst release, and the production of GAG and the expression of type II collagen, aggrecan significantly increased com- pared with the ...
7
Formulation optimization of propranolol hydrochloride microcapsules employing central composite design
... drug release in pH ...the burst release from the formulations A3 and A4 and their inability to sustain the drug release beyond 8 h of dissolution suggested that the intermediate polymer ...
6
Evaluation of Antibacterial Activity and Drug Release Behavior of Chitosan-Based Nanofibers (In Vitro Study)
... drug release behavior between PVA/Cs and PCL/Cs polymeric systems has be studied in PBS ...polymer release about 99% of Ciprofloxacin.HCl drug as burst release within the first two hours, ...
5
In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor
... At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting ...
30
Preparation and In Vitro Evaluation of Biodegradable Microspheres with Narrow Size Distribution for Pulmonary Delivery
... distribution. Therefore, the morphologies of these microspheres prepared by a double emulsion method followed with a membrane emulsification technique (A) and only double emulsion method (B) were recorded first. As shown ...
9
Preparation of novel biodegradable ropivacaine microspheres and evaluation of their efficacy in sciatic nerve block in mice
... the release profile of ropivacaine microspheres exhibited a biphasic pattern: the initial burst release within the first 2 hours and a following slower and sustained release over a long ...
8
FORMULATION DEVELOPMENT AND EVALUATION OF 5-FLUROURASIL AND ECONAZOLE GEL USING RICE BRAN WAX
... initial burst release and retards further drug release from the gel observed in formulations ...drug release in 120 min, which indicated that this concentration of wax can be used as an ...
8
Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
... the burst release of TR from the PLGA matrix was very low and that a sustained release of the drug was ...The burst release was decreased and the TR concentration had the greatest ...
9
“A NOVEL APPROACH TO SUSTAINED ZOLPIDEM TARTRATE RELEASE: COMPRESSED MINI-TABLETS” by Hitesh P. Patel*, Preeti Karwa, Nitesh J. Patel, India.
... Tartrate release profiles from compressed mini-tablets ...the release profiles are characterized by a burst release of Zolpidem Tartrate, followed by a slow release phase, typical of a ...
6
Control of Alginate Core Size in Alginate Poly (Lactic Co Glycolic) Acid Microparticles
... In this study, alginate-PLGA microparticles were synthe- sized through double emulsion solvent extraction and concurrent ionotropic gelation. The alginate core size was tuned by utilizing different emulsification ...
6
Experimental study on promoting the regeneration of rat sciatic nerve using slow release FK506 eluting peripheral nerve stent
... the release of fk506 into the periphery after microsphere degradation still needs to pass through the stent ...the burst release and prolonged the full release to 17 ...
8
Novel sulpiride-loaded solid lipid nanoparticles with enhanced intestinal permeability
... Results: The method adopted allowed successful preparation of SLN with a monodispersed particle size of 147.8–298.8 nm. Both scanning electron microscopic and atomic force microscopic images showed uniform spherical ...
16
FORMULATION AND EVALUATION OF DENTAL FILM FOR PERIODONTITIS
... Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for ...sustained release dental films containing lomefloxacin hydrochloride in a non-biodegradable carrier ...
6