c-Abl
Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules.
... 57, 1986 NOTES Panel A Panel B 123123 P210- -P160 anti-pEX-5 sera were able to reprecipitate the 150,000molecular-weight product of the murine c-abl locus panel B, lanes 1 and 2, respect[r] ...
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Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis
... Cells were lysed in 20 mM Tris pH 7.5, 1 mM EDTA, 100 mM NaCl, 1% Triton X-100, 0.1% SDS, 1 x complete protease inhibitor tablets (Roche Diagnostics, Germany), 1 mM sodium molybdate, 20 mM NaF, 10 mM sodium ...
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The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.
... upper middle panel). Conversely, in anti-CA immunoprecipi- tates analyzed by Western blotting with the anti-c-Abl anti- body, the 140-kDa c-Abl protein could be detected (Fig. 3A, lower left ...
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c Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow
... that c-Abl inhibitor attenuated the integrin a5b1–induced YAP tyrosine ...of c-Abl and YAP Y357 was significantly increased in ECs in atherosclerotic vessels of mice and in human plaques ...
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Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways
... hort C was administered BrdU for 5 days at the same time off doxycyline as cohort A (beginning at about 1 week off doxycyline until 2 weeks off doxycyline) but allowed to age to 6 weeks off ...cohort C ...
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c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression
... of c-Abl in 4T1 cells [27], we next addressed the role of p21 in mediating the anticancer activities CST-Abl in normal and malignant ...CST- Abl in NMuMG cells arrests their proliferation ...
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Mig6 Is a Sensor of EGF Receptor Inactivation that Directly Activates c-Abl to Induce Apoptosis during Epithelial Homeostasis
... of c-Abl we subjected pMECs to lentivirus-mediated shRNA silencing of Abl and cultured the cells in 3D Matrigel for 12 days and examined the formation of lumenized ...for Abl (Figures 7A 0 , ...
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Original Article Imatinib inhibits angiotensin II-induced aortic dissection through the c-Abl signaling pathway
... Protein was extracted from aortic samples (n=5 per group/time point) and treated RASMC with 0.1% sodium dodecyl sulfate (SDS). Total cellu- lar protein concentration was measured by the bicinchoninic acid protein assay ...
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c Src and c Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains
... and Abl family ...that c-Src only phosphorylated EPIYA-C and EPIYA-D, whereas c-Abl phosphorylated EPIYA-A, EPIYA-B, EPIYA-C, and ...
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Activation of tyrosine kinase c Abl contributes to α synuclein–induced neurodegeneration
... of c-Abl is emerging as a consistent feature of sporadic PD (23, 25, ...46–48). c-Abl levels as well as markers of c-Abl activity are increased in sporadic PD (23, 25, ...46–48). ...
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The c Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling
... to c-Abl and c-Abl ⌬ XB through its WW domain, and Fe65 and c-Abl are both present in the ...of c-Abl and c-Abl⌬XB in Fe65 immunoprecipitates from ...
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In vivo differentiation of blast phase chronic granulocytic leukemia Expression of c myc and c abl protooncogenes
... A patient with chronic granulocytic leukemia in acute blastic transformation was treated with mithramycin, an RNA synthesis inhibitor, after in vitro exposure of her leukemic cells to mi[r] ...
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Imatinib mesylate inhibits the profibrogenic activity of TGF β and prevents bleomycin mediated lung fibrosis
... the c-Abelson (c-Abl) proto-oncogene has a potential role in regulating cytokine-mediated fibrosis, since it functions in cell cycle regulation and cytoskeletal remodel- ing and is a downstream ...
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Multistep activation of the Helicobacter pylori effector CagA
... Chronic infection with the Gram-negative bacterium Helicobacter pylori is a major risk factor for the development of gastric cancer. Accumulating evidence indicates that the H. pylori virulence determinant ...
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Subcellular localization of Bcr, Abl, and Bcr Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation
... Bcr, Abl, and Bcr-Abl proteins in leukemic cell lines and in fresh human leukemic and normal samples at various stages of myeloid ...IV c-Abl protein in fibroblasts have shown that this ...
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Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction
... Results: Stimulation with acetylcholine (ACh) increased the interaction of CAS with Pfn-1 in smooth muscle, which was regulated by CAS tyrosine phosphorylation and c-Abl. The CAS/Pfn-1 coupling was also ...
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Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus
... Because c-Abl kinase induces p73 and activates its pro-apoptotic function [11], activation of p73 and its downstream target molecules by nuclear Bcr-Abl suggests that nuclear Bcr-Abl induces ...
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ABL: Alignment Based Learning
... the ABL model against other methods, since often dif- ferent corpora or metrics are ...unsupervised ABL signicantly outperforms this method, reaching ...
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Bcr-abl Silencing by Specific Small-Interference RNA Expression Vector as a Potential Treatment for Chronic Myeloid Leukemia
... In transients silencing experiment using the vector based on expression of siRNA, 30% of Bcr-abl mRNA level is restored within 72 h. Hence, only a transient change in cell proliferation was expected. Surprisingly, ...
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RNA quantification using gold nanoprobes - application to cancer diagnostics
... in cancer development. This Au-nanoprobe strategy allowed for detection of less than 100 fmol/μl of a speci- fic RNA target, with the possibility of discriminating between a positive and negative from as little as 10 ng/ ...
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