c-Jun N-terminal Kinase-3
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Figure 7 Inhibition of pJNK improves the structural and functional deficits caused by inhibition of USP14 ’ s DUB activity. (A) Representative immunoblots of pJNK1/2 and JNK1/2 in spinal cords from 5-week-old wild type ...
18
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... 5D-F), 3-NP (Figure 5G-I), MPP+ (Figure 5J-L) and sodium azide (Figure 5M-O) had no effect on TDP-43 despite being applied at con- centrations that induced the same or increased level of mild cell toxicity ...
22
c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... specific kinase inhibitors, we previously reported that in U-2OS cells NBDHEX causes a p38-dependent arrest in the G2/M phase followed by JNK-dependent apoptosis ...samples. c Lysates from scrambled shRNA- ...
12
Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... The oocytes were cultured in Petri dishes (Nunc, Roskilde, Denmark) for 48 h (39°C, 5% CO 2 ) with 3.0 ml of modified M199 medium Gibco BRL (Life Technologies, Carlsbad, USA) containing sodium bicarbonate ...
11
c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... The complex nature of genetic alterations in transformed cells makes the identification of individual events responsible for func- tional alterations observed difficult. Thus, 3D culture of normal mammary epithelial ...
14
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c Jun N Terminal kinase pathway
... 0.05, n = 3 for each group) (Figure ...The c-Jun protein levels were higher in the control ASO-treated mice compared with MKK7 treat- ment due to increased local cytokine production, such as ...
9
Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats
... Four rats from each group were used in the experiment. The L4–L5 spinal segments were removed, post-fixed, frozen and cut on a freezing microtome (Leica 2000, Germany) at 30-μm thickness. The sections were washed three ...
7
c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... factor that regulates collagenase gene expression (20). Figure 5a shows that SP600125 suppressed AP-1 bind- ing in IL-1–stimulated FLS. The ERK/MEK inhibitor also had a modest effect, but the p38 inhibitor did not alter ...
10
Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... acidic vacuoles (21), so virus was grown in a MeWo mutant cell line, MPR-KD, in which the mannose-6-phosphate receptor, involved in trafficking to late endosomes and lysosomes, is knocked down (7). Virions were isolated ...
14
c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
... washing, sections were reacted with a secondary antibody, which is biotinylated goat anti-rabbit IgG (1:200, Vector Laboratories) or biotinylated horse anti-mouse IgG (1:100, Vector Laboratories) for 2 h at room ...
12
Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I
... a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, ...protein kinase/c-Jun N-terminal kinase (SAPK/JNK), p65, DNA ...
13
Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway
... 1, 3, 2, and 2 in the 0 h, 12 days, 1 day, and 2 days groups, ...2, 3, and 2 deaths were observed in the CS, CS + vehicle, CS + anti- TNF-α antibody, CS + SP600125, and CS + anti-HMGB1 antibody groups, ...
7
Differential roles of p38 MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart
... protein kinase (p38-MAPK) and c-Jun N-terminal kinases (JNKs) by hyperthermia was investigated in the isolated perfused Rana ridibunda ...° C) was found to profoundly stimulate ...
9
Original Article The C-jun N-terminal kinase signaling pathway regulates cyclin D1 and cell cycle progression in airway smooth muscle cell proliferation
... signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) pathways in ASMC proliferation are well established, the mechanisms by which the c-jun N-terminal ...
11
Inhibition of c-Jun N-Terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-Deficient Mice
... To induce standardized changes of shear stress in vivo, we used a cast, which imposes a fixed geometry on the carotid vessel wall, thereby causing gradual stenosis resulting in decreased blood flow upstream from the cast ...
10
Checkpoint inhibitors in hematological malignancies
... T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) was discovered by Monney and col- leagues in 2002 [71]. TIM-3 is also called hepatitis A virus cellular receptor 2 (HAVCR2) and is ...
16
Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer
... a 3% hydrogen peroxide solution to inhibit endogenous peroxidase activity and washed with phosphate-buffered ...staining); 3: 11–50% of cells and 4: >50% of ...
13
Flavonoids in modulation of cell survival signalling pathways
... ERK, c-Jun N-terminal kinase (JNK), and p38, MAPKs (Johnson and Lapadat ...protein kinase (SAPK), is an important member of the MAPKs super- family, the members of which are ...
9
Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... vertebrates, Jun N-terminal kinase (JNK) is also required for tissue elongation, but the precise cellular role of JNK in this context has remained ...Rho kinase is necessary to induce ...
10
5444.pdf
... limiting neurotransmitter diffusion. On average, a single cortical astrocyte domain surrounds four neuronal cell bodies and hundreds of dendrites (Halassa, Fellin et al. 2007). In the CA1 region of the hippocampus, it ...
184