c-Met, Ras/MAPK pathway
Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
... in RAS/ MAPK pathway genes were identified in 9 of the 25 patients with AVMs (Tables 1 and 2 and Figure 3) and confirmed by a second meth- ...the RAS/MAPK signaling pathway, ...
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RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action
... the RAS- MAPK pathway due to a direct interaction with KRAS mRNA ...activate RAS-MAPK signaling pathway and promote brain metastasis ...the RAS-MAPK pathway ...
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Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans
... To guarantee sufficient exposure to each compound ana- lyzed, both the NGM plates and the OP50 bacteria were supplemented with the experimental compounds (drugs) being tested. Either vehicle (DMSO solvent) alone or ...
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MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma
... p53, RAS/MAPK, PI3K/ Akt/mTOR, Wnt/β-cateninβ, MET, Myc gene, transforming growth factor-β, resulting in molecu- lar genetic and epigenetic histological ...
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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
... in RAS/ MAPK pathway genes were identified in 9 of the 25 patients with AVMs (Tables 1 and 2 and Figure 3) and confirmed by a second meth- ...the RAS/MAPK signaling pathway, ...
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Targeted next generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer
... repair pathway for the triple-negative breast cancer (TNBC) subgroup, the RTK/RAS/MAPK and cell cycle pathways for the HR – /HER2 + subgroup, the DNA repair, RTK/RAS/MAPK, and NOTCH ...
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Original Article Williams syndrome transcription factor is a target of pro-oncogenic Ser158 phosphorylation mediated by Ras-MAPK pathway in human breast cancer
... After fixing with 4% paraformaldehyde for 15 min, MCF-7 cells were treated by immunofluo- rescence dual-labeling method. In brief, rabbit anti-human WSTF antibody (ab51256, Abcam, USA) and mouse anti-human p44/42 MAP ...
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Epileptic spasms in PPP1CB-associated Noonan-like syndrome: a case report with clinical and therapeutic implications
... hypoglycemia; hyperuricemia; hypoproteinemia; hypomag- nesemia; hyponatremia; hepatitis and metabolic acidosis; nephrolithiasis; osteopenia, osteoporosis and bone fractures; growth failure. Fortunately, our patient ...
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<p>Natural gypenosides: targeting cancer through different molecular pathways</p>
... MAPK/ERK pathway, also known as the Ras-Raf-MEK- ERK pathway, possesses several cascades and is mostly deregulated in human ...The MAPK/ ERK pathway molecules are activated ...
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Original Article Expression and clinical significance of the RAS/RAF/MAPK cell signaling pathway in gastric cancer
... the Ras/Raf/MAPK signaling pathway and the development of gastric ...of Ras, p-Raf-1, MAPK, and CyclinD1 proteins in the two groups of tissues were detected by ...of MAPK and ...
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Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia
... the RAS-MAPK1 and RAS-AKT pathways, which have been found to be activated and support AML leukemogenesis ...anti-leukemic, RAS targeting strategy in ...the RAS-MAPK1 and RAS-AKT kinase ...
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UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer
... the Ras/MAPK path- way promotes cyclinD1 expression and inhibits the p21 and p27 levels ...Moreover, MAPK signaling path- way is correlated with cell adhesion, angiogenesis, inva- sion, and ...
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Abnormal insulin like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts
... Radin and coworkers were the first to study subchondral bone changes in patients with early degenerative joint disease, and to propose the participation of subchondral bone in the initia- tion and progression of ...
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Menin determines K RAS proliferative outputs in endocrine cells
... Pancreatic histology. Mice were euthanized by carbon dioxide asphyxiation, and tissues were isolated by dissection using a dissecting stereoscope. Tissues were then fixed in 4% paraformaldehyde (PFA) at 4°C for 2 ...
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The role of HGF/c-MET signaling pathway in lymphoma
... high c-MET copy numbers was as- sociated with an unfavorable prognosis ...of c-MET copy number on prognosis is a histological subtype dependent: c-MET amplification with a poorer ...
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Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target
... Ataxia Telangiectasia Mutated (ATM) gene encodes a serine/threonine protein kinase, which is a master regulator of cell cycle checkpoint in response to DNA damage for the maintenance of genomic stability [48- 50]. The ...
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Regulation and functional analysis of EphA2 in normal and Ras-transformed mammary epithelium
... signalling pathway from RTKs to Ras was discovered by genetic analysis using ...of Ras is involved in vulval ...Let-60 Ras-like protein and downstream of the Let-23 ...signalling ...
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Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
... Although mutant FGFR3 activates MAPK pathway but not PI3K pathway signalling in NHUCs61, immunohistochemistry for phosphorylated ERK an indicator of MAPK pathway activation does not show[r] ...
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Pathway to RAS
... as RAS when I called him. We then knew that RAS in ...signaling pathway (H an and S ternberg 1990). What controls RAS? And what does it actually ...
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bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling
... the RAS family transduce extracellular signals and activate a multitude of pathways via activation of effector proteins ...of RAS family members which in turn activate MAPK and AKT, respectively ...
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