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Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway

Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca<sup>2+</sup>-dependent pathway

... were divided into four groups: control, BaPTa, Baicalin, and Baicalin+ BaPTa group. (C) The apoptotic cell ratio of the four groups was measured by flow cytometry. The Baicalin+ BAPTA group showed a less apoptotic ...

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Cu2+-RGDFRGDS: exploring the mechanism and&nbsp;high efficacy of the nanoparticle in antithrombotic therapy

Cu<sup>2+</sup>-RGDFRGDS: exploring the mechanism and&nbsp;high efficacy of the nanoparticle in antithrombotic therapy

... After the thrombotic study, 9 mL of fresh blood, from the carotid artery of the anesthetized rats, was collected into centrifuge tubes containing 1 mL of 3.8% sodium citrate. Blood samples were centrifuged (1,811 g, 30 ...

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Partial sciatic nerve ligation leads to an upregulation of Ni2+-resistant T-type Ca2+ currents in capsaicin-responsive nociceptive dorsal root ganglion neurons

<p>Partial sciatic nerve ligation leads to an upregulation of Ni<sup>2+</sup>-resistant T-type Ca<sup>2+</sup> currents in capsaicin-responsive nociceptive dorsal root ganglion neurons</p>

... ricated from borosilicate glass capillaries (Science Products, Hofheim, Germany) using a P-97 Flaming/Brown Micro- pipette Puller (Sutter Instrument Company, Novato, CA, USA). One cell per culture dish was analyzed. ...

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Blockage of store-operated Ca2+ entry antagonizes Epstein&ndash;Barr virus-promoted angiogenesis by inhibiting Ca2+ signaling-regulated VEGF production in nasopharyngeal carcinoma

Blockage of store-operated Ca<sup>2+</sup> entry antagonizes Epstein&ndash;Barr virus-promoted angiogenesis by inhibiting Ca<sup>2+</sup> signaling-regulated VEGF production in nasopharyngeal carcinoma

... Notes: (A) The scheme for establishing an EBV-positive/EBV-negative xenograft-bearing mouse model is illustrated. (B) The EGFP-encoding sequence was simultaneously introduced into CNE2 and HK1 cells with the infectious ...

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Role for 11C choline PET in active surveillance of prostate cancer

Role for <sup>11</sup>C choline PET in active surveillance of prostate cancer

... In total, 24 patients with low-risk prostate cancer were enrolled into this study from April 2009 to May 2012. The inclusion criteria were: histologically proven adenocarcin- oma of the prostate classified as low-risk ...

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The ocular distribution of 14C-labeled bromfenac ophthalmic solution 0.07% in a rabbit model

The ocular distribution of <sup>14</sup>C-labeled bromfenac ophthalmic solution 0.07% in a rabbit model

... Of note, if one uses an estimate of 1 mL for the volume of a gram of tissue, it follows that ocular tissue levels of bromfenac following topical administration of bromfenac ophthalmic solution 0.07%, pH 7.8 were ...

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Skeleton labeled 13C-carbon nanoparticles for the imaging and quantification in tumor drainage lymph nodes

Skeleton labeled <sup>13</sup>C-carbon nanoparticles for the imaging and quantification in tumor drainage lymph nodes

... amorphous carbon powder (15 wt%). Pure graphite rod was set as the cathode. The arc discharge was performed under Ar atmosphere (135 Torr) with the following parameters: inter- electrode distance of 5 mm, current of 110 ...

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Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats

Disposition and metabolism of [<sup>14</sup>C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats

... The quantification of levomilnacipran and its metabolites in plasma and urine was performed by the bioanalysis unit of Institut de Recherche Pierre Fabre (Castres, France). Concentrations of levomilnacipran and its ...

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Designing of CD8+ and CD8+-overlapped CD4+ epitope vaccine by targeting late and early proteins of human papillomavirus

Designing of CD8<sup>+</sup> and CD8<sup>+</sup>-overlapped CD4<sup>+</sup> epitope vaccine by targeting late and early proteins of human papillomavirus

... In total, 80 CTL epitopes were predicted from the early proteins E1 (19), E2 (17), E4 (01), E6 (05), and E7 (14), and late proteins L1 (07) and L2 (17) of HPV45 based on MHC class I supertype by NetCTL 1.2 (threshold ...

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Dexmedetomidine attenuates persistent postsurgical pain by upregulating K+&ndash;Cl&minus;&nbsp;cotransporter-2 in the spinal dorsal horn in rats

Dexmedetomidine attenuates persistent postsurgical pain by upregulating K<sup>+</sup>&ndash;Cl<sup>&minus;</sup>&nbsp;cotransporter-2 in the spinal dorsal horn in rats

... polyacrylamide gel and finally transferred to a nitrocellulose membrane. The membrane was incubated with mouse anti- KCC2 (1:300; Sigma-Aldrich Co.), anti-BDNF (1:250; Sigma- Aldrich Co.), and anti-TrkB (1:500; Abcam, ...

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Mp[sup]c structures and applications

Mp[sup]c structures and applications

... n 2 ], C a rtie r C C rl, Itzykson C I n i , Rawnsley [Ry5], Segal [ S t ] , Sternberg & Wolf CSw], ...i c i t computations with the metaplectic representation - in p a r t ...

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Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

Synthesis and evaluation of <em>ortho</em>-[<sup>18</sup>F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

... H 2 O in a polypropylene- based reservoir as shown in Figure S1 and Table ...At 2 h postreaction, the cell pellets from all time points were detached by using 200 µ L of 4N HCl ...H 2 O (2 ...

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Identification of capsazepine as a novel inhibitor of system xc&minus; and cancer-induced bone pain

Identification of capsazepine as a novel inhibitor of system x<sub>c</sub><sup>&minus;</sup> and cancer-induced bone pain

... BALB/c nude mice bearing successful MDA-MB-231 grafts in the right femur as determined by histological analyses were included in the study (Figure 4). The DPA and DWB tests were consistent, showing a steady ...

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A VISIBLE ALLELE OF THE MUSCLE GENE sup-10 X OF C. ELEGANS

A VISIBLE ALLELE OF THE MUSCLE GENE sup-10 X OF C. ELEGANS

... IVA GREENWALD’ AND H. We describe an unusual, visible allele of sup-IO, examine how this allele interacts genetically with mutations in other genes o f this set an[r] ...

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Asthma patients prefer Respimat&reg; Soft Mist&trade; Inhaler to Turbuhaler&reg;

Asthma patients prefer Respimat<sup>&reg;</sup> Soft Mist<sup>&trade;</sup> Inhaler to Turbuhaler<sup>&reg;</sup>

... appearance, a double-dummy design was used; thus, patients used both devices for the full duration of the trial. All patients were randomly allocated to study treatment with budesonide for 12 weeks according to one of ...

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Series Solutions of the Anharmonic Motion Equation y" + y2 = C

Series Solutions of the Anharmonic Motion Equation y" + y<sup>2</sup> = C

... y  A and y '(0)  0 (2) This has resulted in the problem being called Rayleigh problem [3]. Other researchers who studied and solved anharmonic motion equations later on are, for example, Shidfar and Sadeghi [4], ...

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Mimicking ClassIb Mn2 Ribonucleotide Reductase: A MnII2Complex and Its Reaction with Superoxide

Mimicking ClassIb Mn<inf>2</inf> Ribonucleotide Reductase: A Mn<sup>II</sup><inf>2</inf>Complex and Its Reaction with Superoxide

... In order to further understand the Mn oxidation states in 2 we performed Mn K-edge X-ray absorption near-edge spectroscopy (XANES) on frozen solutions of 1 and 2. The first inflection of the rising edge was ...

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Re2EMA: Regularized and Reinitialized Exponential Moving Average for Target Model Update in Object Tracking

Re<sup>2</sup>EMA: Regularized and Reinitialized Exponential Moving Average for Target Model Update in Object Tracking

... choose KCF (Henriques et al. 2015), Staple (Bertinetto et al. 2016b), SRDCF (Danelljan et al. 2015) and BACF (Ga- loogahi, Fagg, and Lucey 2017). From Siamese network family, we select SiamFC (Bertinetto et al. 2016c) ...

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Effects of vildagliptin (Galvus&reg;) therapy in patients with type 2 diabetes mellitus after heart transplantation

Effects of vildagliptin (Galvus<sup>&reg;</sup>) therapy in patients with type 2 diabetes mellitus after heart transplantation

... During the follow-up time of 8 months, HbA 1c levels in the VG decreased significantly from 7.4 % ± 0.7% at base- line to 6.8 % ± 0.8% at follow-up (P = 0.002, Figure 1). In the CG, HbA 1c levels were 7.0 % ± 0.7% at ...

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Laser-based measurements of 18O/16O stable isotope ratios (&delta;18O) in wine samples

Laser-based measurements of <sup>18</sup>O/<sup>16</sup>O stable isotope ratios (&delta;<sup>18</sup>O) in wine samples

... In practice, this training methodology would involve using a set of “known wines” that have been characterized by IRMS and a set of “unknown wines” whose isotope ratios need to be determined. In order to mimic this ...

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