C-terminal domain
Requirement for the E1 Helicase C-Terminal Domain in Papillomavirus DNA Replication In Vivo
... a C-terminal tail (C-tail), FIG 1 Schematic representation of the papillomavirus E1 helicase highlighting the conservation of the C-terminal ...helicase/ATPase domain [ATP(SF3)] ...
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C-terminal domain of SMYD3 serves as a unique HSP90- regulated motif in oncogenesis
... the C-terminal domain (CTD) is essential for SMYD3’s histone methyltransferase (HMTase) activity, as truncates of either the whole CTD or even just the three C-terminal helices of the ...
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Structure of the C terminal domain of the Prokaryotic Sodium Channel Orthologue NsvBa
... single domain polypeptides, with a C-terminal domain (CTD) composed of an inter-subunit four helix ...the C-termini form a disordered region adjacent to the final transmembrane helix, ...
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The C-Terminal Domain of ERp29 Mediates Polyomavirus Binding, Unfolding, and Infection
... the C-terminal arms of the VP1 pen- tamers are exposed in an ERp29-dependent manner (12), we suspect that helix ␣ 9 of the ERp29 CTD likely makes contact with this region of the viral ...
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Structure of C-terminal Domain of Parkin, IBR-RING2
... Parkin is an E3 ubiquitin ligase which degrades misfolded proteins and prevents the formation of abnormal protein aggregates often formed in Parkinson’s disease. The main goal of this thesis was to perform structural ...
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Structure of the C-Terminal Domain of Lettuce Necrotic Yellows Virus Phosphoprotein
... aligned residues and, therefore, are less sensitive to local structural variations than the root mean square deviation (RMSD) alone (Table 2). The value of these scores increases from 0 to 1 with increasing structural ...
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Role of the C terminal domain in the structure and function of tetrameric sodium channels
... Comparison of the distance distributions between spin labels derived from DEER experiments were made with predictions using the MMM approach 17 . The rotamer library and populations used by MMM are derived from detailed, ...
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Salmonella typhimurium SifA effector protein requires its membrane anchoring C terminal hexapeptide for its biological function
... the C-terminal domain of SifA as a membrane targeting signal, its 11 C- terminal residues were fused to the cytosolic proteins GFP and GFP 䡠 ...11 C-ter- minal amino acid ...
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Li, Liang (2017): Structural and biochemical charaterization of the C. elegans SMG8-SMG9 core complex. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the C-terminal domain was co-expressed with CeSMG8 (1-423) in insect ...the C-terminus of CeSMG9 and identified a shorter fragment CeSMG9 ...and C-terminal truncation of CeSMG9 ...
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From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective
... b, c and wings on the side (Fig 3B and ...and c densities in Legionella was termed the elbow [preprint: ...the c density was ascribed to CagM, although this would need to be ...the c density; ...
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Radicicol-Mediated Inhibition of Topoisomerase VIB-VIA Activity of the Human Malaria Parasite Plasmodium falciparum
... binding domain, H2TH (helix 2 turn helix) domain, and transducer domain ...transducer domain mediates communication between the N-terminal clamp and the C-terminal ...
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The bovine papillomavirus type 1 E2 transactivator and repressor proteins use different nuclear localization signals.
... common C-terminal domain that has DNA-binding and dimerization ...this domain forms an alpha helix which makes direct contact with the DNA ...DNA-binding domain and in a heterol- ogous ...
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The dominant PNM2- mutation which eliminates the psi factor of Saccharomyces cerevisiae is the result of a missense mutation in the SUP35 gene.
... We also show that just as the PNM2 phenotype requires only an intact N-terminal domain, so SAL3 function only re- quires translation of an intact C-terminal domain and [r] ...
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Molecular basis for the control of motor-based transport of MHC class II compartments
... (RILP), recruits the dynein–dynactin motor to LEs, resulting in minus end–driven vesicular transport to the MTOC (Jordens et al., 2001). The Rab7–RILP–dynein motor cascade has been shown to act on many Rab7-containing ...
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Characterization of the Bacillus subtilis Penicillin Binding Protein PBP4
... the C-terminal domain (comprising 92 residues) on the folding, stability or enzymatic activity of PBP4*, the recombinant N-terminal (PBP) domain of 361 residues was also produced ...
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The Hypervariable Domain of the Murine Leukemia Virus Surface Protein Tolerates Large Insertions and Deletions, Enabling Development of a Retroviral Particle Display System
... hypervariable domain linking the N-terminal receptor-binding domain and the highly conserved C-terminal domain of MuLV SUs was further in- vestigated by constructing a series of ...
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Distinct and mutually inhibitory binding by two divergent β catenins coordinates TCF levels and activity in C elegans
... POP-1 C ⌬ 39, and dramatically decreased with POP-1 T425D. The POP-1 C-terminal domain is required specifically for WRM-1 binding, as SYS-1 binding to POP-1 C ⌬ 39 or POP-1 T425D was ...
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Regulation of the transforming immortalized mammary protein and its homologs by auto-inhibition and tyrosine phosphorylation
... serve to stabilize the auto-inhibited state. These secondary stabilizing interactions would be lacking in the in vitro exchange assays using purified components such that even modest perturbation to the auto-inhibition ...
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Characterization of a Tos17 Insertion Mutant of Rice Auxin Signal Transcription Factor Gene, OsARF24
... To assess the activity of the OsARF24 gene product in vivo, we fused the full-length OsARF24 cDNA to the rice Actin promoter in the sense orientation (Act::OsARF24) and introduced the construct into wild-type rice by ...
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Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C Terminal Processing Proteases
... PDZ domain and the proteolytic site, we engineered five Prc mutants, as follows: (i) Prc-ΔPDZ, in which residues 247 to 339 are deleted (4); (ii) Prc-L252Y, which has a mutation designed to block the PDZ ...
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