C-terminal domain (CTD)
Genetic Interactions With C-Terminal Domain (CTD) Kinases and the CTD of RNA Pol II Suggest a Role for ESS1 in Transcription Initiation and Elongation in Saccharomyces cerevisiae
... potential CTD kinases have been identified, each mination, and transcript cleavage (Lee and Young ...compo- C-terminal domain (CTD) of the pol II large subunit, nent of TFIIH, ...
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Chapman, Rob (2003): A Functional Analysis of the RNA Polymerase II Large Subunit C-Terminal Domain. Dissertation, LMU München: Fakultät für Biologie
... 5 CTD repeats (LS*∆5), exhibit no resistance to ...a CTD truncated to 31 repeats (LS*∆31) (Meininghaus et ...existing CTD deletion mutants, still contained the last CTD ...the CTD ...
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Structure of C-terminal Domain of Parkin, IBR-RING2
... One of the point mutations in the IBR region linked to ARJP, G349E (human G328E), is located on the surface of the IBR domain. It was inferred previously with the human IBR domain (Beasley et al., 2007) ...
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Involvement of the C-Terminal Disulfide-Bonded Loop of Murine Leukemia Virus SU Protein in a Postbinding Step Critical for Viral Entry
... this domain was derived from determination of its crystal structure ...receptor-binding domain (RBD) is linked via a proline- rich region (PRR) to the C-terminal domain (CTD) of ...
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Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins
... common domain structure with two tandem CARD motifs at the N terminus which are respon- sible for downstream signaling, a central DECH RNA helicase domain with ATPase activity and a C-terminal ...
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A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2
... helicase C domain as the site of V protein association with MDA5 and ...cysteine-rich C-terminal domain is sufficient to mediate association with the LGP2 and MDA5 MVBR ...(Mu) ...
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Surf the Post-translational Modification Network of p53 Regulation
... the C-terminal domain of RNA polymerase II [75, ...the CTD of p53, especially the 6 lysines acetylated by p300/CBP and K320 acetylated by P300/CBP-associated factor ...
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Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort
... kinase domain (KD), ubiquitin-like domain (ULD), a-helical scaf- fold dimerization domain (SDD), and C-terminal domain (CTD) ...the CTD re- gion, which were ...
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Insight into the LGP2 Helicase Domain – An in Silico Approach
... recruitment domain (CARD) ...conserved C-terminal domain (CTD), which is responsible for the binding specificity to the viral ...2RQA) C-terminal domain ...
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Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia
... binding domain; ATED: aminoacyl‑tRNA editing domain; CRS: cysteinyl‑ tRNA synthetase; CTD: c‑terminal domain; DRS: aspartyl‑tRNA synthetase; DALR: aspartate (D), alanine (A), ...
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RNA Polymerase II during Transcript Elongation: deaiing with DNA damage and staying phosphorylated
... the C-terminal domain (CTD) of R pbl, the largest subunit of RNA polymerase II, regulates transcription as well as other transcription-linked cellular ...many CTD kinases have been ...
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Molecular basis for the control of motor-based transport of MHC class II compartments
... (RILP), recruits the dynein–dynactin motor to LEs, resulting in minus end–driven vesicular transport to the MTOC (Jordens et al., 2001). The Rab7–RILP–dynein motor cascade has been shown to act on many Rab7-containing ...
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Characterization of the Bacillus subtilis Penicillin Binding Protein PBP4
... the C-terminal domain (comprising 92 residues) on the folding, stability or enzymatic activity of PBP4*, the recombinant N-terminal (PBP) domain of 361 residues was also produced ...
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Salmonella typhimurium SifA effector protein requires its membrane anchoring C terminal hexapeptide for its biological function
... the C-terminal domain of SifA as a membrane targeting signal, its 11 C- terminal residues were fused to the cytosolic proteins GFP and GFP 䡠 ...11 C-ter- minal amino acid ...
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The dominant PNM2- mutation which eliminates the psi factor of Saccharomyces cerevisiae is the result of a missense mutation in the SUP35 gene.
... We also show that just as the PNM2 phenotype requires only an intact N-terminal domain, so SAL3 function only re- quires translation of an intact C-terminal domain and [r] ...
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The Hypervariable Domain of the Murine Leukemia Virus Surface Protein Tolerates Large Insertions and Deletions, Enabling Development of a Retroviral Particle Display System
... hypervariable domain linking the N-terminal receptor-binding domain and the highly conserved C-terminal domain of MuLV SUs was further in- vestigated by constructing a series of ...
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Li, Liang (2017): Structural and biochemical charaterization of the C. elegans SMG8-SMG9 core complex. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the C-terminal domain was co-expressed with CeSMG8 (1-423) in insect ...the C-terminus of CeSMG9 and identified a shorter fragment CeSMG9 ...and C-terminal truncation of CeSMG9 ...
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From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation
... Neurofibromin regulates neuronal morphogenesis The fact that patients with NF1 are frequently associated with multiple neurobehavioral developmental disorders suggests an important role of neurofibromin in brain ...
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Distinct and mutually inhibitory binding by two divergent β catenins coordinates TCF levels and activity in C elegans
... POP-1 C ⌬ 39, and dramatically decreased with POP-1 T425D. The POP-1 C-terminal domain is required specifically for WRM-1 binding, as SYS-1 binding to POP-1 C ⌬ 39 or POP-1 T425D was ...
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Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain
... During infection the conformation of cellular host mem- branes changes in a number of ways. One of these mem- brane alterations is the membranous web (MW), composed of small vesicles embedded in a membrane matrix [8]. ...
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