C-type lectin-like
The Structure of the Poxvirus A33 Protein Reveals a Dimer of Unique C-Type Lectin-Like Domains
... The current vaccine against smallpox is an infectious form of vaccinia virus that has significant side effects. Alternative vaccine approaches using recombinant viral proteins are being developed. A target of subunit ...
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Identification and Characterization of a Spliced C-Type Lectin-Like Gene Encoded by Rat Cytomegalovirus
... a C-type lectin-like domain that is expressed in the delayed-early and late phases of the viral replication ...several C-type lectin- containing molecules implicated in ...
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Modulation of monosodium urate crystal induced responses in neutrophils by the myeloid inhibitory C type lectin like receptor: potential therapeutic implications
... inhibitory C-type lectin-like receptor (MICL) in neutrophils is downregulated by several proinflammatory stimuli, suggestive of a role for this receptor in neutrophil ...
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Localization and characterization of C type lectin like family of proteins in Leptospira interrogans
... of C-type lectin-like proteins. C-type lectin-like domains (CTLDs) occur in many different species of animals, bacteria and ...
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Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease
... Another form of arthritis associated with the production of IL-1β is gout. This is an inflammatory arthritis caused by precipitation of MSU crystals in the joint. It is distin- guished from RA and OA by the clinical ...
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Targeting CLL-1 for acute myeloid leukemia therapy
... identify C-type lectin-like molecule-1 (CLL-1) which is expressed on 92% AML and absent on granulocyte-macrophage progenitors (GMPs) ...
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PDGF upregulates CLEC-2 to induce T regulatory cells
... The effect of platelet derived growth factor (PDGF) on immune cells is not elucidated. Here, we demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 secretion. Culture of PDGF-DCs with T cells induced ...
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In silico analysis of C-type lectin domains’ structure and properties
... ubiquitous, as just like NG2 it may be expressed by, or interact with, a limited population of cells. It is not clear whether CBCP is a proteoglycan. Of the known family members only NG2 glycosylation has been ...
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Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors
... mannose-binding lectin (MBL), a prototypic soluble calcium-dependent (C-type) lectin, is a key first line host defense molecule and immune ...as C-type lectin, scavenger, ...
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The role of thrombomodulin lectin-like domain in inflammation
... protein C activation was ...protein C but still has the same renoprotective effect as the wild type TM indicating the importance of TMD1 anti-inflammatory effect ...
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Myeloid dendritic cells display downregulation of C type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus
... the C-type lectin receptors ...more C-type lectin domains, and may bind carbohy- drate moieties in a calcium-dependent manner ...
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mosGCTL-7, a C-Type Lectin Protein, Mediates Japanese Encephalitis Virus Infection in Mosquitoes
... mosGCTL-7 facilitates JEV infection in A. aegypti. To investigate the function of mosGCTL-7 in JEV infection, RNA interference (RNAi) and overexpression methods were used (42, 43). Female mosquitoes were separated into ...
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C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map
... ing C-type lectin receptors, RIG-I-like receptors, and the proteins of their signaling pathways with various aspects of cancer development may include confounding host, bacterial, or ...
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The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection
... CLEC18: C-type lectin 18; ELISA: Enzyme-linked immunosorbent assay; FIB-4: Fibrosis-4; FRG: Fah − / − /Rag2 − / − /Il2rg − / − ; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; HBV: ...
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Hemagglutinating activity of Chickpea extracts for lectin
... The lectin activity greatly varies between the seeds that were investigated, although they belong to closely related ...different lectin composition in these seed ...higher lectin activity compared ...
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Mutations in the carboxyl-terminal hydrophobic sequence of human cytomegalovirus glycoprotein B alter transport and protein chaperone binding.
... (59). Like calnexin, calreticulin plays an important role in the maturation and quality control of newly synthesized cellular and viral glycoproteins (29, 32, ...
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The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus
... the C-type lectin receptor langerin in Lec2 cells (Lec2-Lg) rendered them permissive to IAV infection, as measured by replication of the viral genome, transcription of viral mRNA, and synthesis of ...
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Cloning and characterization of a mannose binding C type lectin gene from salivary gland of Aedes albopictus
... fragment was cloned into the pMD18-T vector (TaRaKa) firstly, it was completely digested with Nde I and Hind III (TaRaKa), and cloned into the Nde I and Hind III sites of the expression vector pET28a(+) subsequently, ...
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Hitting with a BAM: Selective Killing by Lectin Like Bacteriocins
... LlpA-resistant mutants carry a modified surface loop in BamA. The non-LPS mutants (B2, B4, and B5a/B5b [identical transition in B5a and B5b]) all carried missense mutations in pfl01_1109, which encodes the essential  ...
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Characterization of Caenorhabditis elegans lectin-binding mutants.
... (Because surface lectin binding is restricted to small regions of the adult wild-type animal, mutants missing this lectin binding are difficult to identify in a dissecting micro- sc[r] ...
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