C3H/HeJ
Neutralization of Gamma Interferon Augments Borreliacidal Antibody Production and Severe Destructive Lyme Arthritis in C3H/HeJ Mice
... Development of a high level of sustained borreliacidal antibody is paramount for maintaining protection against infection with Borrelia burgdorferi. We show that production of borreliacidal antibody can be enhanced by ...
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Role for monokines in the metabolic effects of endotoxin Interferon gamma restores responsiveness of C3H/HeJ mice in vivo
... LPS-sensitive C3H/OuJ mice and in LPS-resistant C3H/HeJ mice, whose macrophages are defective in the ability to produce tumor necrosis factor (TNF) and IL-1 in response to ...LPS. HeJ mice ...
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Macrophages from endotoxin-hyporesponsive (Lpsd) C3H/HeJ mice are permissive for vesicular stomatitis virus because of reduced levels of endogenous interferon: possible mechanism for natural resistance to virus infection.
... In this report, we have demonstrated that, like macrophages from anti-IFN-a/ antibody-treated mice, peritoneal exudate macrophages from the endotoxin-hyporesponsive C3H/HeJ mouse strain [r] ...
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Lyme Arthritis: Current Concepts and a Change in Paradigm
... Unlike neutrophils, large populations of monocytes, acti- vated macrophages, and mature dendritic cells are found in EM lesions (125), the sites of initial B. burgdorferi infection. The presence of TLR2, which binds ...
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Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks
... Confocal microscopy to determine the distribution of live Bb914 within freshly isolated, nymphal midguts and salivary glands. Bb914-infected flat nymphs and infected nymphs removed from naive C3H/HeJ mice ...
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Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function
... TLR4 contributes to myocardial infarction by inducing a systemic and a myocardial cytokine response after MI/R. It has to be considered that TLR4-independent pathways are also activated due to MI/R and contribute to ...
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Mapping the Flv locus controlling resistance to flaviviruses on mouse chromosome 5.
... The first set of backcross mice, C3H/HeJ x C3H/RVF, x C3H/HeJ, was typed for the inheritance of C3H/RV alleles at the Flv, Eta-i, and rd loci Tables 1 and 2.. The C3H/RV allele at the rd[r] ...
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Aberrant Light Induced Depression is Associated with Impaired Sensorimotor Gating in Mice
... in C3H/HeJ mice (n = 4) subjected to the aberrant ...in C3H/HeJ mice (n = 4) subjected to the T7 ...of C3H/HeJ mice in T7 cycle was confirmed by two independent ...
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Quantitative Detection of Borrelia burgdorferi by Real Time PCR
... can be seen in Fig. 4A, the treatment almost completely abol- ished the development of joint swelling and there were no signs of inflammation in the treated group of mice, in comparison to the control, infected ...
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Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice Association with aortic fatty streak development
... Incidence, Distribution, and Quantity of Cardiac Lipofuscin in Female C57BL/6J, C3H/HeJ, and BALB/cJ Mouse Strains Fed Either Chow or the A TH Diet for 15 wk Incidence of cardiac lipofus[r] ...
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SJL/J Mice Are Highly Susceptible to Infection by Mouse Adenovirus Type 1
... of MAV-1 (INF) (lanes 2 to 5 and 8 to 11) were isolated at 8 days p.i. RNAs were analyzed by RT-PCR with MAV-1 E3-specific primers MAVR24718 and MAVR25148 for 40, 45, or 50 cycles (top, middle, and bottom panels, ...
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Lysosomal β glucuronidase regulates Lyme and rheumatoid arthritis severity
... strains, C3H/HeJ, AKR/J, and CBA/J, share this Gusb coding ...Both C3H and AKR/J have previously been shown to develop severe Lyme arthritis (13, ...
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Genetic analysis of endogenous xenotropic murine leukemia viruses: association with two common mouse mutations and the viral restriction locus Fv-1.
... Described herein are 40 endogenous Xmv xenotropic murine virus loci 9 from A/J, AKR/J, BALB/cJ, C57BL/ 6J, C57L/J, C3H/HeJ, and DBA/2J inbred strains, as defined by junction fragment seg[r] ...
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Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets.
... 4568 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We identified mouse mammary tumor proviral loci in the AKR/J, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, and SWR/J inbred m[r] ...
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High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata
... the C3H/HeJ model, to determine if clonality was significantly increased around the time of hair loss, we used a 2-tailed Student’s t test, and we used a 1-way ANOVA to determine if the clonality of ...
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A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice
... lies within a proline rich domain (PRINTS: PR01217) that is involved in binding the ‘‘SH3 domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55),’’ which is known to stimulate the ...
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Activation of mouse lymphocytes by vesicular stomatitis virus.
... CBA/J and C3H/HeJ female mice were obtained from Jackson Laboratories Bar Harbor, Maine and maintained in our facility on Purina mouse Downloaded from http://jvi.asm.org/ on November 10,[r] ...
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In vivo inflammatory activity of epidermal cell derived thymocyte activating factor and recombinant interleukin 1 in the mouse
... C3H/HeJ mice were injected with 0.05 ml of medium containing ETAF in the left hind footpad and medium alone in the right hind footpad.. Groups of three mice each were killed at the times[r] ...
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Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice
... After 15 wk of consumption of the atherogenic diet, the parental C57BL/6J and C3H/HeJ strains and BXH recombinant inbred strains were assessed for aortic lesion formation by standard his[r] ...
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Role of toll-like receptor 4 in acute neutrophilic lung inflammation induced by intratracheal bacterial products in mice
... In C3H/HeN mice, the plasma TNF- α level was signifi cantly increased after LPS instillation, whereas LPS did not increase the plasma TNF- α level compared with the control group in C3H/HeJ mice ...
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