C57BL/6 mouse
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain
... the C57BL/ 6 mouse strain, the preferred strain for genetic modification [11] has been shown to be resistant to developing CKD by subtotal nephrectomy ...
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Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains
... Cholesterol content in cell and brain extracts was evalu- ated by the Amplex Red Cholesterol Assay kit (Invitro- gen) according to the manufacturer ’ s instructions. Briefly, mouse brain and cell extracts were ...
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The GLN Family of Murine Endogenous Retroviruses Contains an Element Competent for Infectious Viral Particle Formation
... the C57BL/6 mouse genome ...human, mouse, rat, hamster, or dog cell lines (the mouse MCA cells are from C3H mice, 3T3 [WOP] cells from NIH/Swiss mice, and LOK cells from 129/B6/DBA2 ...
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CYTOCHROME P450-DEPENDENT METABOLISM OF L-DEPRENYL IN THE BRAIN OF DIFFERENT EXPERIMENTAL MAMMALS
... Although the CYP content of brain is too low to significantly influence the overall pharmaco- kinetics of drugs and hormones in the body, brain CYP could play a role in tissue- and/or cell- specific sensitivity to ...
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Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction
... To better characterize the potential influences of the JAK- STAT pathway during scrapie infection, we analyzed RNA isolated from brains of 22L scrapie-infected mice at various times postin- fection by using two qRT-PCR ...
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Peripheral Blood Gamma Interferon Release Assays Predict Lung Responses and Mycobacterium tuberculosis Disease Outcome in Mice
... inbred mouse strains to ...resistant C57BL/6 mouse ...disease-susceptible mouse strains, suggesting that similar results may occur in ...
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Oral infection of mice with Salmonella entericaserovar Typhimurium causes meningitis and infection of the brain
... a C57BL/6 mouse infected with Salmonella enterica serovar Typhimurium (plus Additional file 1) which shows rolling behavior as a prominent feature of intracranial infec- ...given mouse. (B). ...
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Chimeric drift and immunological tolerance in allophenic mice
... Analysis of serum blocking activity using C57BL/6 mouse sera and CBA X CBA/H-T6F, parental spleen white blood cells.. Analysis of serum blocking activity using C57BL/6DBA/1 mouse sera an[r] ...
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Lymph node-derived donor encephalitogenic CD4+T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet
... the C57BL/6 mouse strain it appears that high expression of IL-17 by transferred donor cells is not absolutely required for disease ...day 6 LNC is not sufficient to induce CNS autoimmune ...a ...
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Original Article Retinoid X receptor ligand regulates RXRα/Nur77-dependent apoptosis via modulating its nuclear export and mitochondrial targeting
... in C57BL/6 mouse hippocampus in Alzheimer’s disease pathologic condition, and investigated the effect of RXRα exporting inhibition caused by 9-cis-RA on the apoptosis of ...
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Original Article B7-2 gene silencing by lentivirus-mediated delivery of shRNA reduces progression of experimental lupus nephritis
... To evaluate the intervention effects of lentivi- rus-shRNA (425) on B7/CD28 signal and the progress of SLE, a C57BL/6 mouse model of lupus nephritis was induced by a single intra- peritoneal ...
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Heritability of the Maternal Meiotic Drive System Linked to Om and High-Resolution Mapping of the Responder Locus in Mouse
... offspring inheriting maternal DDK alleles in the central region of mouse chromosome 11 due to meiotic drive at the second meiotic division. We have shown previously that the locus subject to selection is in the ...
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Activation of an Antiviral Response in Normal but Not Transformed Mouse Cells: a New Determinant of Minute Virus of Mice Oncotropism
... voviruses to the antiviral activities of these cytokines (20, 54). In a first step, exogenously applied rmIFN-  was tested for its ability to stimulate the JAK/STAT pathway in transformed A9 fibroblasts, as measured by ...
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MetabR: an R script for linear model analysis of quantitative metabolomic data
... strains C57BL/6J and DBA/2J were used in this ...and 6 (“Mouse example data 2”), corresponding to metabolites detected in positive and negative ionization modes, ...
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Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice.
... PFU). Clinically, the sensitive B6 mice showed symptoms of acute central nervous system (CNS) disease, including tremors, seizures, ataxia, and paralysis. Light microscopic examination of CNS tissue from the B6 animals ...
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B Cells Regulate Murine Gammaherpesvirus 68 Latency
... Possible relationship between regulation of viral latency and clinical course of g HV68 infection. It is clear that the clinical outcome of gHV68 infection in B-cell-deficient mice is very different from that in ...
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Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice.
... For the detection of virus-specific intestinal and serum IgA, plates were coated and blocked as for the antigen detection ELISA and then incubated with a dilution of RRV stock virus (1:8 in 1% BLOTTO) overnight at 4 8 C. ...
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Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie
... Propagation of a mixture of strains is supported by the data from the VM mice where, while the overall IHC characteristics of scrapie prevailed, a subtle but distinct BSE feature was observed in mice challenged with BSE/ ...
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Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency
... RNA was extracted from isolated islets and DNAse trea- ted using an RNeasy Micro Kit from Qiagen (Cat. No. 74004). cDNA was prepared from 20 ng total RNA using Moloney Murine Leukemia Virus Reverse Transcriptase, RNase H ...
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Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis
... for microarray analysis. Two samples were run with technical duplicates, which showed good reproducibility for hybridization, normalization of the data and clustering (data not shown). Whole genome expression profiles ...
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