C5a(1) receptor
Complement C5a Receptor 1 Exacerbates the Pathophysiology of N meningitidis Sepsis and Is a Potential Target for Disease Treatment
... and C5a are released during the complement ...(9). C5a induces a more profound proinflammatory response than C3a (10) and is a strong chemoattractant for cells of the myeloid lineage as a consequence of ...
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An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization
... and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause ...that C5a receptor (C5aR) blockade promotes Th2 ...
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Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis
... the C5a receptor (CD88) was measured as specific mean fluorescence intensity of the whole population of granulocytes and monocytes, and as the relative amount of CD88-positive granulocytes and ...monocyte ...
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C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA
... Anaphylatoxin C5a is a strong chemoattractant and an important factor of the complement system [11, ...The C5a receptor (C5aR) is a G-protein coupled receptor expressed by leukocytes ...[13]. ...
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Increased C5a receptor expression in sepsis
... product C5a appears to be harmful during the development of sepsis in ...the C5a receptor (C5aR) and its presence in different organs during ...
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The complement system in glioblastoma multiforme
... C3a Receptor; C5aR1: C5a Receptor-1; C5b-9: Membrane Attack Complex; cC1qR: collagen C1q Receptor (Calreticulin); CNS: Central Nervous System; CREB: Cellular Transcription Factor; CSF 1: ...
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C5a induced expression of P selectin in endothelial cells
... studies, C5a had been found to cause in a time- and dose-dependent manner rapid expression of endothelial P-selectin, secretion of von Willebrand factor, and adhesiveness for human ...of C5a in P-selectin ...
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Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis
... Also, C5a and C5a receptor expression levels were reported to be ele- vated in the lung, liver, kidney, pituitary gland, and heart during sepsis [5, ...of C5a were also found in the brain ...
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Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264 7 macrophages
... between C5a and Nod2 signaling in RAW ...enhanced C5a-me- diated expression of chemokine mRNAs in RAW ...a receptor for C5a which acts as a negative modulator of C5a receptor ...
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The interaction between C5a and sphingosine 1 phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation
... C5aR: C5a receptor; C5L2: C5a receptor-like 2; DHR: dihydrorhodamine; EDTA: ethylene diamine tetraacetic acid; EGPA: eosinophilic granulomatosis with polyangiitis; ELISA: enzyme- linked ...
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Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis
... Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are sub- stantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the ...
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Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo
... mate receptor, and administration of KA has been shown to increase production of reactive oxygen species, mito- chondrial dysfunction, and apoptosis in neurons in brain ...that C5a may neuroprotect against ...
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Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss
... the C5a receptor gene [32], were crossed with Arctic +/ − mice to produce Arctic mice lacking C5aR1 (Arctic/C5aR1KO) and wild type littermate mice lacking the C5a receptor (C5aR1KO) that were ...
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C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment
... proteins C5a and C5a-des Arg bind to two G-protein coupled receptors (GPCR); namely the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called ...that ...
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A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
... Complement component 5 (C5) has been described as either promoting or protecting against airway hyperresponsiveness (AHR) in experimental allergic asthma, suggesting pleomorphic effects of C5. Here we report that local ...
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The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres
... anaphylatoxin C5a, a 74 amino acid glycoprotein, functions primarily as a pro-inflammatory mediator ...of C5a results in a host of inflammatory responses, including increased vascular per- meability, ...
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Inhibition of complement C5a prevents breakdown of the blood brain barrier and pituitary dysfunction in experimental sepsis
... anaphylatoxin C5a has been characterised as a mediator of BBB dysfunction in a variety of central nervous system (CNS) disorders, includ- ing traumatic brain injury and bacterial meningitis ...the C5a ...
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Complement-targeted therapy: development of C5- and C5a-targeted inhibition
... but C5a receptor antagonists target C5a alone and do not inhibit MAC, so those antagonists may lessen risk of an infection with a pathogen such as Neisseria meningitidis seen with eculi- ...the ...
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Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
... 2012. C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular ...
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Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
... The major findings of the current study are that in the TA muscle of hSOD1 G93A mice, the terminal comple- ment system (C5a and C5aR1) is up-regulated, and the complement receptor C5aR1 is responsible for ...
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