C5a Receptor
Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis
... the C5a receptor (CD88) was measured as specific mean fluorescence intensity of the whole population of granulocytes and monocytes, and as the relative amount of CD88-positive granulocytes and ...monocyte ...
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C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA
... Anaphylatoxin C5a is a strong chemoattractant and an important factor of the complement system [11, ...The C5a receptor (C5aR) is a G-protein coupled receptor expressed by leukocytes ...[13]. ...
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Increased C5a receptor expression in sepsis
... product C5a appears to be harmful during the development of sepsis in ...the C5a receptor (C5aR) and its presence in different organs during ...
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Complement C5a Receptor 1 Exacerbates the Pathophysiology of N meningitidis Sepsis and Is a Potential Target for Disease Treatment
... the C5a peptide, and it remains unclear whether this potent anaphylatoxin contributes to protection and/or drives the rapidly progressing immunopathogenesis associated with meningococcal ...of C5a ...
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An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization
... and C5a, respec- tively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause bronchoconstric- ...that C5a receptor (C5aR) ...
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Inhibition of complement C5a prevents breakdown of the blood brain barrier and pituitary dysfunction in experimental sepsis
... anaphylatoxin C5a has been characterised as a mediator of BBB dysfunction in a variety of central nervous system (CNS) disorders, includ- ing traumatic brain injury and bacterial meningitis ...the C5a ...
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Complement-targeted therapy: development of C5- and C5a-targeted inhibition
... and C5a receptor antagonists may be efficacious at treat- ing various inflammatory diseases involving ...and C5a receptors. C5a levels in synovial fluid are elevated in patients with RA [16], ...
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The complement system in glioblastoma multiforme
... C3a Receptor; C5aR1: C5a Receptor-1; C5b-9: Membrane Attack Complex; cC1qR: collagen C1q Receptor (Calreticulin); CNS: Central Nervous System; CREB: Cellular Transcription Factor; CSF 1: ...
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The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres
... anaphylatoxin C5a, a 74 amino acid glycoprotein, functions primarily as a pro-inflammatory mediator ...of C5a results in a host of inflammatory responses, including increased vascular per- meability, ...
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The interaction between C5a and sphingosine 1 phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation
... C5aR: C5a receptor; C5L2: C5a receptor-like 2; DHR: dihydrorhodamine; EDTA: ethylene diamine tetraacetic acid; EGPA: eosinophilic granulomatosis with polyangiitis; ELISA: enzyme- linked ...
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Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis
... Also, C5a and C5a receptor expression levels were reported to be ele- vated in the lung, liver, kidney, pituitary gland, and heart during sepsis [5, ...of C5a were also found in the brain ...
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C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment
... proteins C5a and C5a-des Arg bind to two G-protein coupled receptors (GPCR); namely the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called ...that ...
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Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss
... the C5a receptor gene [32], were crossed with Arctic +/ − mice to produce Arctic mice lacking C5aR1 (Arctic/C5aR1KO) and wild type littermate mice lacking the C5a receptor (C5aR1KO) that were ...
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Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo
... mate receptor, and administration of KA has been shown to increase production of reactive oxygen species, mito- chondrial dysfunction, and apoptosis in neurons in brain ...that C5a may neuroprotect against ...
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Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis
... Additionally, SNPs in genes encoding complement pathway proteins have been linked to susceptibility to pneumococcal infection, although no associations with disease severity or outcome have been established. Here, we ...
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C5a induced expression of P selectin in endothelial cells
... studies, C5a had been found to cause in a time- and dose-dependent manner rapid expression of endothelial P-selectin, secretion of von Willebrand factor, and adhesiveness for human ...of C5a in P-selectin ...
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Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
... 2012. C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular ...
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In vivo clearance and tissue distribution of C5a and C5a des arginine complement fragments in rabbits
... response observed with both mediators. Clearance of the mediators was primarily seen in the highly vascularized organs: the lung, spleen, liver, and kidney. A time-dependent accumulation was seen initially in the lung, ...
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Effects of anti C5a antibodies on the adult respiratory distress syndrome in septic primates
... develop decreased oxygenation (P less than 0.05) or increased extravascular lung water (P less than 0.05). They also had a marked recovery in their mean arterial blood pressure (P less than 0.05). This study demonstrates ...
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Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release
... where C5a was a potent histamine release stimulus. Supernatants from C5a-challenged mast cells remained fully active on basophils, excluding carboxypeptidase inactivation of C5a as an explanation for ...
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