C5b-9
Urinary C5b-9 and cytokines in idiopathic human membranous nephropathy
... who developed renal impairment. This non-randomised prospective trial was to assess the short and medium-term effect of three commonly used treatment regimens on the clinical course and the excretion of ...
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Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients
... diffuse C5b-9 deposition in either muscle or nerve vessels should raise the concern of diabetes, a condition present in a significant propor- tion of the nerve biopsies received at our ...of ...
9
Original Article CD4 cells, macrophages, MHC-I and C5b-9 involve the pathogenesis of dysferlinopathy
... and C5b-9 was performed using muscle biopsy samples from 14 patients with dysfer- linopathy, 7 patients with polymyositis, and 8 patients with either Duchenne muscular dystrophy or Becker muscular dystrophy ...
7
Blockade of C5a and C5b 9 generation inhibits leukocyte and platelet activation during extracorporeal circulation
... and C5b-9 formation), platelets (increased percentages of P-selectin-positive platelets and leukocyte-platelet conjugates), and neutrophils (upregulated CD11b ...soluble C5b-9 generation and ...
10
DNA damage is a novel response to sublytic complement C5b 9–induced injury in podocytes
... sublytic C5b-9–induced podocyte injury causes DNA damage in podocytes in vitro and in ...sublytic C5b-9 did not cause DNA damage in ...is C5b-9 ...that C5b-9 also ...
10
Paroxysmal nocturnal hemoglobinuria type III Lack of an erythrocyte membrane protein restricting the lysis by C5b 9
... erythrocytes (PNH-E) are susceptible to lysis by human complement. In human erythrocytes (huE) the species restriction is ascribed to an integral membrane protein, designated C8- binding protein (C8bp). In the present ...
7
Complement Lysis of Human Erythrocytes: DIFFERING SUSCEPTIBILITY OF TWO TYPES OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA CELLS TO C5b 9
... The present studies, making use of carefully selected cases with pure populations of type II or type III erythrocytes, confirm a prior observation that antibody-coated PNH erythrocytes of both types II and III display ...
7
The terminal complement proteins C5b 9 augment binding of high density lipoprotein and its apolipoproteins A I and A II to human endothelial cells
... complexes C5b-9 have been found in human atherosclerotic ...of C5b-9 in the endothelial cell membrane alters permeability, induces membrane vesiculation, and activates ...inhibit ...
9
Predominant role for C5b 9 in renal ischemia/reperfusion injury
... before coronary occlusion, reduced myocardial infarct size after reperfusion in rats (23). Using cobra venom factor (CVF) to deplete C in rats, Ikai et al. showed that systemic shock was reduced in intestinal I/R (24), ...
10
Terminal complement complex C5b 9 stimulates mitogenesis in 3T3 cells
... We report here that in Swiss 3T3 cells, the MAC enhances the mitogenic effect of serum and PDGF, and also stimulates cell proliferation in the absence of exogenous growth factors.. The p[r] ...
6
Excretion of complement proteins and its activation marker C5b-9 in IgA nephropathy in relation to renal function
... Correlations between urinary complement levels and interstitial fibrosis, and between urinary complement levels and percentage of global glomerular sclerosis, were evaluated in IgAN pati[r] ...
8
Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica
... Control studies were done to support a complement bystander mechanism for neuron killing in the astrocyte-neuron cocultures. Cocultures incubated with AQP4-IgG and C1q-depleted serum did not show cell killing or ...
11
Strong predictive value of mannose binding lectin levels for cardiovascular risk of hemodialysis patients
... Fig. 1 Patient plasma levels of mannose‑binding lectin, properdin, C3d and C5b‑9 before, after and relative change during hemodialysis. The distri‑ bution of plasma mannose‑binding lectin (MBL) (a), ...
12
The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study
... local C5b-9 complement complex and its relation with a complement regulator, the Membrane Cofactor Protein (MCP, CD46) on skin vascular bed as target distinctive of SSc ...
15
Original Article Eperythrozoon suis infection enhances atherosclerosis in low-density lipoprotein receptor-deficient mice
... for 10 min, and then a rabbit antibody against EP (College of Animal Science and Technology, Hebei North University, Hebei, PR China) and a rabbit anti-C5b-9 (Shanghai Ruiqi Biotech Company, Shanghai, ...
11
Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain
... HRP kit (Vector Labs, Peterborough, UK). We counter- stained nuclei with haematoxylin. Primary antibodies were rabbit anti-AQP4 (1:100), rabbit anti-glial fibrillary acidic protein (GFAP, 1:200), mouse anti-NeuN (1:200), ...
9
The complement system in glioblastoma multiforme
... classical complement pathway share many elements, includ- ing cross-activation, shared binding proteins and control mechanisms [43]. C1 inhibitor (C1 INH) inhibits the bradykinin-forming cascade at several levels: its ...
12
The effects of Eculizumab on the pathology of malignant atrophic papulosis
... Results: The patient had received eculizumab as a emergent life saving measure and following rapid improvement he continued with biweekly infusions for 4 years. Although improved he continues to have signs and symptoms ...
9
Activation of terminal components of complement in patients with Guillain Barré syndrome and other demyelinating neuropathies
... inactive C5b-9 containing S protein, was assessed quantitatively by enzyme-linked immunosorbent assay using an antibody (Ab) to neoantigens expressed on C9 when complexed with C5b-8 or after tubular ...
7
Complement Activation in Patients With Diabetic Nephropathy
... inhibits C5b-9 under physiological conditions 11,18 ; this glycation-induced complement dysregulation leads to increased C5b-9 levels in patients with ...
12