C6 glioma
Polymer Delivery of Hydroxycamptothecin against C6 Glioma
... for C6 cells tested in ...with C6 glioma and treated with hydroxycamptothecin polymer compared to intravenous as well as intratumoral injections; the median survival is ...
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Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death
... to C6 glioma cells along with a high quercetin concentration causing a reduction in glutathione content and quercetin to accumulate a high reactive oxygen species level for that ...
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Crocin induced apoptosis through p53-dependent pathway in C6 glioma Cells
... in C6 glioma ...[15]. Glioma tumors retain wild type p53; hence the ability to maintain the tumor phenotype depends on down regulated expression of p53 ...in C6 glioma cells compared ...
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Original Article Therapy of C6 glioma with liposomal doxorubicin in rats: a MR diffusion-weighted imaging study
... growth becomes more active over time, the tumor cell density also increases, and ADC at different areas reduces over time, which are inconsistent with our findings. In previous stud- ies, Wistar rats were used, but SD ...
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Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats
... rat-derived C6 glioma cell ...in C6 cells impaired the formation of G418-resistant colonies better than either the p53 or Rb tumor suppres- sor ...
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Topographical control of cell cell interaction in C6 glioma by nanodot arrays
... Nanotopography modulates the physiological behavior of cells and cell-cell interactions, but the manner of communication remains unclear. Cell networking (syncytium) of astroglia provides the optimal microenvironment for ...
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Effects of ginsenosides Re and Rg3 on intracellular redox state and cell proliferation in C6 glioma cells
... Ginsenosides Re and Rg3 (purity>99%) were obtained from International laboratory (USA). The identities of ginsenosdies were confirmed by high-performance liquid chromatography (HPLC) and electrospray ionization – mass ...
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The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma
... Our results demonstrate progressive generation microglia population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain as indicated by phenotypic and functional in- dices of ...
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Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation
... on C6 glioma cells in vitro and in vivo. DCA inhib- ited C6 glioma cell proliferation, induced C6 cell apoptosis, and arrested C6 cells in S ...of C6 glioma tumors ...
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Sensitization of rat C6 glioma cells to ionizing radiation by porphyrins
... Morphologically, C6 glioma is similar to glioblastoma multiforme (GBM) when injected into the brain of neona- tal ...rats. C6 glioma cell line is a useful experimental model system for the ...
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Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
... Comet assay was performed using the Comet Assay kit (KEYGEN BIOTECH. CO., Nanjing, China) according to the manufacture’s instruction. After treatment with 1, 5, 10 μM of lapachol for 48 h, the cells were harvested and ...
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Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
... of C6 glioma cells with 5 μM mevasta- tin, 5 μM fluvastatin or 10 μM simvastatin for 72 h in vitro inhibited GGPP ...of C6 glioma cells with ...
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CALCIUM MODULATORY EFFECTS OF CROCIN FROM SAFFRON (CROCUS SATIVUS L.) IN C6 GLIOMACELLS
... The studies were performed on C6 cell line; Rattus Norvegicus glioma-derived cell line. The cells were cultured, subcultured and cryopreserved as per instructions (ATCC/ CCL-107) in DMEM supplemented with ...
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Synthesis and characterization of Agiopep-2 anchored PEGylated poly propyleneimine dendrimers for targeted drug delivery to glioblastoma multiforme
... assay. C6 glioma cells were used to evaluate the cytotoxicity of PAPP ...dendrimers. C6 glioma cells were seeded in 96-well plates with a density of 10,000 cells/well, and allowed to adhere ...
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Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells
... The I B-NF B pathway is involved in TNF- a -induced IL-6 release from C6 glioma cells [4]. NFB binds to its consensus sequence on a target gene promoting tran- scription and upregulation of gene expression ...
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Magnetic resonance imaging of glioma with novel APTS coated superparamagnetic iron oxide nanoparticles
... the C6 glioma cells were incubated with PBS buffer for 4 ...million C6 glioma cells (10 μL) that were la- beled with the acetylated APTS-coated Fe 3 O 4 NPs ...
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Neonatal dexamethasone treatment exacerbates hypoxic-ischemic brain injury
... reduction in GLT-1 expression in the frontal cortex by neonatal DEX treatment. However, this finding is in con- trast with observations made in a previous study, which reported that DEX provokes an increase of GLT-1 ...
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Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells
... rat C6 glioma cells and that IL-1b induces phosphorylation of inhibitory kappa B (IB), p38 mitogen-activated protein (MAP) kinase, stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), ...
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Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood-brain barrier model system
... of C6 glioma ...in C6 glioma sCp gene expression in the presence of hBMVEC can be repressed through the inhibition of ei- ther the IL-1R1 or the gp130 signal transducer molecule involved in ...
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MAGI3 negatively regulates Wnt/ -catenin signaling and suppresses malignant phenotypes of glioma cells
... in glioma, and its expression level is negatively correlated with tumor grade and the prognosis of glioma patients (Figures 1 and ...In glioma cells, MAGI3 overexpression inhibited proliferation and ...
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