Ca2+/calmodulin dependent kinase II
Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice
... myocardium leads to dilated cardiomyopathy and ventricular dys- function (16). These findings, taken with abundant evidence for upregulated expression and activation of CaMKIIδ in humans and animal models of heart ...
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Ca2+/calmodulin dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart
... lowing myocardial infarction (MI), but the CaMKII-dependent pathways that participate in myocardial stress responses are incompletely understood. To address this issue, we sought to determine the transcriptional ...
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The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling
... the generation of diacylglycerol and inositol phosphate (IP). CaMKIIα is a kinase that could contribute to the phosphorylation and desensitization of group I mGluR G protein coupling. We focused our investigation ...
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Eph and NMDA receptors control Ca2+/calmodulin dependent protein kinase II activation during C elegans oocyte meiotic maturation
... The maturation rates of unc-43(e408) and unc-43(n1186) null hermaphrodites are slightly slower than the wild-type rate, raising the possibility that unc-43 is a positive regulator (Table 1, compare lines 19, 20 and 5; ...
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Investigation of neuronal cell type-specific gene expression of Ca2+/calmodulin-dependent protein kinase II
... developmentally. In the adult rat, the α isoform is abundant in the forebrain, whereas the β isoform is abundant in the cerebellum (8,9). The enzyme level is increased most rapidly in postnatal brain during the most ...
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Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin dependent protein kinase II and Ca2+/Calmodulin dependent protein phosphatase 2B imbalance in APPV717I mice
... Calcineurin (CaN), also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent serine/threonine phosphatase physiologically activated by Ca 2+ . It is also highly expressed in the central nervous ...
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Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice
... CaMKII-dependent phosphorylation of PLN (residue T17) was higher in right-atrial appendages of patients in chronic AF than in sinus rhythm patients (31). Elevated PLN phosphorylation occurred despite higher total ...
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Linkage of β1 adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
... cAMP/protein kinase A (PKA) pathway to regulate vital cellular processes from the change of gene expression to the control of metabolism, muscle contraction, and cell .../calmodulin kinase II ...
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Ca2+/Calmodulin-dependent protein Kinase II interacts with group I Metabotropic Glutamate and facilitates Receptor Endocytosis and ERK1/2 signaling: role of β-Amyloid
... Group I mGluRs serve as molecular scaffold proteins to regulate both extracellular and intracellular signaling complexes. Specifically, mGluR5 functions as a receptor to mediate intracellular Ca 2+ signaling and ...
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Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... In heart failure (HF), Ca 2+ /calmodulin kinase II (CaMKII) expression is increased. Altered Na + channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF. ...
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Molecular basis for the modulation of native T type Ca2+ channels in vivo by Ca2+ /calmodulin dependent protein kinase II
... Ang II receptor activation increases cytosolic Ca 2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic stimulus that adversely influences cardiovascular ...
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AMP activated protein kinase regulates CO2 induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K ATPase endocytosis
... ylation (Figure 5, A and B). To confirm that CaMKK-β was the kinase upstream of AMPK during hypercapnia, a siRNA approach was uti- lized to knock down CaMKK-β expression in A549 cells. Silencing of CaMKK-β was ...
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Journal of Applied Pharmaceutical Science
... a kinase-inactive analog of KN93, did not affect opioid tolerance, study conducted by Fan et al (1999) supported the above ...signal-regulated kinase(ERK) due to participation of up-regulation of PKC and ...
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Release from the metaphase I block in invertebrate oocytes: possible involvement of Ca2+/calmodulin dependent kinase III
... Int J De\ IIi,,! 37 279 290 (1993) 279 Original Article Release from the metaphase I block in invertebrate oocytes possible involvement of Ca2+/calmodulin dependent kinase III HAYA ABDELMAJID,,4, CATH[.] ...
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The CaMKII/NMDAR complex as a molecular memory
... CaMKII is a major synaptic protein that is activated during the induction of long-term potentiation (LTP) by the Ca 2+ influx through NMDARs. This activation is required for LTP induction, but the role of the ...
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Betaine promotes cell differentiation of human osteoblasts in primary culture
... As recently reviewed [4], BET favours lipolysis and inhibits lipogenesis via gene and protein expression; it promotes the autocrine/endocrine release of insulin- like growth factor type I (IGF-I), and modulates its rela- ...
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Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling
... tion of HDAC5 nuclear export through CaMKII in adult ventricular cardiomyo- cytes (2). HDAC4/5 activity and nuclear occupancy are directly regulated by CaMK-, PKC-, and protein kinase D–mediated (PKD-mediated) ...
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QUANTUM MECHANICAL NATURE OF PAIN SENSITIVITY
... www.wjpr.net Vol 8, Issue 9, 2019. 33 depolarization as well as by hydration-induced increase of functionally active ionic channels in the membrane. [4,2] It is known that the Na + /K + pump inactivation leads to the ...
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Elevated intracellular Ca2+ acts through protein kinase C to regulate rabbit ileal NaCl absorption Evidence for sequential control by Ca2+/calmodulin and protein kinase C
... cytosol Ca2+, while W13 had no ...the Ca2+/calmodulin complex and not by protein kinase C; (b) the effect of elevating intracellular Ca2+ to decrease NaCl absorption is mediated via ...
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Calcium signaling around Mitochondria Associated Membranes (MAMs)
... Obviously, other proteins that are required to modu- late calcium mobilization upon cellular stimulation are directed to MAMs. An example is the anti-apoptotic protein AKT/PKB that, in response to survival signals, is ...
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