Ca2+ channels
Endothelin induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine sensitive Ca2+ channels
... dihydropyridine-sensitive Ca2+ channels in cultured vascular smooth muscle (VSM) ...cell Ca2+ can be altered in VSM by activation of voltage- operated Ca2+ ...dihydropyridine Ca2+ ...
6
Isoform specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L type Ca2+ channels
... Cav1.2 and Cav1.3 L-type Ca2+ channels LTCCs are believed to underlie Ca2+ currents in brain, pancreatic β cells, and the cardiovascular system.. In the CNS, neuronal LTCCs control excit[r] ...
11
Anti-peptide antibodies as probes of the structure, function and distribution of Ca2+ channels
... Peptides sequences were selected from regions of the protein predicted to be accessible on the channel surface. The latter was done following comparison of the polypeptides sequences from different channels (see ...
312
Molecular basis for the modulation of native T type Ca2+ channels in vivo by Ca2+ /calmodulin dependent protein kinase II
... and III of the channel pore (II-III loop). Activation of the kinase mediated the phosphorylation of Ser1198 in the II-III loop and the positive feedback regulation of channel gating both in intact cells in situ and in ...
11
Mn2+ Ions Pass Through Ca2+ Channels in Myoepithelial Cells
... The results show that the myoepithelial cells of the proventriculus are capable of undergoing regenerative activity, that the overshooting spikes elicited both by transmitter substance a[r] ...
14
Novel ways to regulate T-type Ca2+ channels
... This sensitivity to redox modulation of Cav3.2 is specific amongst the Cav3 isoforms, and arises because of the presence of an extracellular, high affinity binding site for trace metals [r] ...
6
Dynamic imaging of functional nerve terminals and Schwann cells in presynaptic 'nerve plates' isolated from the skate electric organ
... The components of the nerve plate could be loaded with the Ca2+-sensitive dyes Fluo-3 and Key words: skate, electric organ, nerve terminals, Schwann cells, presynaptic Ca2+ channels, pur[r] ...
11
Mitochondria structure and position in the local control of calcium signals in smooth muscle cells
... While, in smooth muscle, Ca2+ influx via voltage-dependent Ca2+ channels appears not to be tightly controlled at a local level by mitochondria Figure 9.2 [44,45], nonetheless, the sites [r] ...
20
Activation of Ca2+ dependent K+ channels in human B lymphocytes by anti immunoglobulin
... external Ca2+ abolished the prolonged ...lymphocytes, Ca2+-dependent K+ channels can be activated by crosslinking of surface ...voltage-sensitive Ca2+ channels, Na+ can permeate through ...
7
Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia Reoxygenated Neonatal Rat Cardiomyocytes
... The Ca2+ entry across the membrane through L-type Ca2+ channels is balanced by the efflux of Ca2+ from the cell via the NCX and PMCA1.36 In the present results, the density of L-type Ca2[r] ...
10
The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M type K+ channels and activation of Ca2+ activated Cl– channels
... M channel openers and CaCC blockers can reduce nocifensive behavior induced by BK. We next tested whether pharmacological targeting of M channels and CaCC can influence BK-induced nocifensive behavior in rats. We ...
14
Ryanodine-induced vasoconstriction of the gerbil spiral modiolar artery depends on the Ca2+ sensitivity but not on Ca2+ sparks or BK channels
... BK channels or SMC-specific genetic manipulation of BK channel or RyR expression leads to the loss of this hyperpolarizing signal leading to membrane depolarization, increased VDCC activation, increase in Ca 2+ ...
12
Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension
... BK channels from RyRs by the loss of the β 1 subunit alone is sufficient to induce ...BK channels with a diminished capacity to regulate vas- cular ...BK channels were less sensitive to activation by ...
9
Original Article Hydrogen sulfide improves cardiomyocytes electrical remodeling post ischemia/reperfusion injury in rats
... Abstract: Hydrogen sulfide (H 2 S), produced by cystanthionine-γ-lysase (CSE) in the cardiovascular system, is an endogenous gaseous mediator exerting pronounced physiological effects as the third gasotransmitter in ...
8
Hypoxic regulation of ion channel function and expression
... Such an effect is likely to be a major contributory factor in pulmonary hypertension associated with hypoxic adaptation. In the carotid body type I cell, maxi-K channel functional expression was suppressed in rats born ...
11
Voltage dependent and Ca2(+) activated ion channels in human neutrophils
... To investigate the regulation of membrane voltage and transmembrane ion fluxes in human neutrophils, we studied plasma membrane currents using the whole-cell patch-clamp method. We observed three distinct ion channel ...
9
Activation of Ca permeable cation channels by myocarditis associated antibody in guinea pig ventricular myocytes
... cation channels that were insensitive to dihydropyridines and membrane ...> Ca2+ > Na+ approximately K+, and the single-channel conductance to Ba2+ was 12 ...
5
Modulation of cyclic nucleotide gated channels and regulation of vertebrate phototransduction
... CNG channels by phosphorylation Neurotransmitter modulation of physiological processes, such as neurotransmitter release and muscle contraction, often involves ‘cross-talk’, in which one biochemical signaling ...
11
Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary
... To obtain channel current-voltage relationships a voltage protocol ranging from -80 mV to +90 mV in 10 mV steps was used with each potential applied for 200 ms. For eval- uation of channel open probability P o , single ...
10
Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... overexpression. CaMKII coimmunoprecipitates with and phosphorylates Na + channels. In vivo, transgenic CaMKIId C overexpression prolonged QRS duration and repolarization (QT intervals), decreased effective ...
13