Ca2+ signals
Three dimensional spatio temporal modelling of store operated Ca2+ entry: insights into ER refilling and the spatial signature of Ca2+ signals
... Mathematical models have previously been used to further our under- standing of SOCE [34, 35, 25]. Using a modified whole cell Ca 2+ model based on [36], Ong et al. [34] compared the level of SOCE activation induced by ...
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Methods for the study of ionic currents and Ca2+-signals in isolated colonic crypts
... for the characterization of the Ca 2+ -permeable channels in the plasma membrane or for the study of the origin of the Ca 2+ responsible for activation of anion secretion, experiments ca[r] ...
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Alternating bipolar field stimulation identifies muscle fibers with defective excitability but maintained local Ca2+ signals and contraction
... 2+ signals (right panel) and ...2+ signals (right panel) and corresponding Ca 2+ transients time course, respectively, of a MDX myofiber displaying alter- nate (ALT-MDX) responses to alternate polarity ...
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The calcineurin pathway links hyperpolarization (Kir2 1) induced Ca2+ signals to human myoblast differentiation and fusion
... 2+ signals may be required for a full differentiation to take place, and that only the signal activating calcineurin is directly linked to the induction of the differentiation leading to myoblast ...2+ ...
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Calcium signaling and cell fate: how can Ca2+ signals contribute to wrong decisions for Chronic Lymphocytic Leukemic B lymphocyte outcome?
... It has been now firmly established that the Bcl2 protein contrib- utes through its ability to inhibit apoptosis to cancer progression mechanisms and modulation of response to cancer therapeutic agents (Akl et al., 2014). ...
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Ca2+ signals coordinate zygotic polarization and cell cycle progression in the brown alga Fucus serratus
... Ca2+ buffer effects on cell cycle progression and zygotic polarization were compared by measuring three parameters 24 hours after fertilization: first, cytosolic Ca2+ buffer concentratio[r] ...
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Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L
... non-immune signals. Positive and negative signals evoke a delicate interplay of signal transduction pathways in the target lymphocytes which will eventually determine cellular responses, ...2+ ...
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Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses
... splicing signals derived from the pMSG vector (GE Healthcare), was inserted using a Red/ ET Recombination system (Gene Bridges) into a bacterial artificial chromosome clone, RP23-361H22 (BAC PAC Resources), ...
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Characterization of the tissue level Ca2+signals in spontaneously contracting human myometrium
... The slow recruitment of myocytes into the contractile state has been explained by the ‘action potential – calcium wave’ hypothesis, which postulates that action potentials propagate alon[r] ...
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Increased vascular contractility in hypertension results from impaired endothelial calcium signaling
... Summary • Local endothelial Ca2+ signals at junctions between endothelial and smooth muscle cells normally limit contraction but this Ca2+ signaling circuit is disrupted in hypertension [r] ...
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High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission
... We showed that plasma membrane TRPM2 channels responded to oxidative stress to generate Ca2+ signals, which induced lysosomal membrane permeabilisation leading to the mobilisation of lys[r] ...
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Ca2+ signalling and mitochondrial dynamics in the exocrine pancreas: physiology and pathophysiology
... Finally, given the importance of mitochondrial distribution in the maintenance of physiological Ca2+ signals, and the pivotal role of mitochondrial function in pancreatic acinar cell fat[r] ...
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Primitive organization of cytosolic Ca(2+) signals in hepatocytes from the little skate Raja erinacea
... confocal microscopy (Nathanson and Mariwalla, 1996). Cells were prepared as described above, then loaded with rhod- 2/AM (4 µmol l −1 ) for 1–2 h at 15 °C in elasmobranch Ringer solution containing 10 % fetal calf serum. ...
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The effects of prostaglandin F2α on the force / calcium relationship in pregnant rat myometrium
... In uterine smooth muscle, contraction is Ca2+-dependent, with an increase in [Ca2+]i needed for contraction to occur, this increase in [Ca2+]i is the result of Ca2+ influx through Ltype [r] ...
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Effects of sea water and stanniectomy on branchial Ca(2+) handling and drinking rate in eel (Anguilla anguilla L )
... Effects of stanniectomy on ATP- and Na+-dependent Ca2+ transport The kinetics of the Ca2+-ATPase and Na+/Ca2+-exchanger in basolateral plasma membrane vesicles of the gills of freshwater[r] ...
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Chain reaction Ca2+ signaling in the heart
... On a beat-to-beat basis, Ca 2+ entry through voltage-gated Ca 2+ Nonstandard abbreviations used: [Ca2+]i, cytosolic Ca2+ concentration; [Ca2+]SR, SR Ca2+ concentration; CASQ2, calsequest[r] ...
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Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle
... 11 Calcium Mobilization via Intracellular Ion Channels, Store Organization… 245 raded Ca2+ Release, Ca2+ Waves and Local Ca2+ Events G from a Luminally-Continuous Store If the Ca2+ sto[r] ...
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Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury
... (see Methods, Equation 2, Supplementary Methods and Supplementary Figure 3) assuming that NO: (i) is generated within and released from the irradiated cell; (ii) diffuses freely across the extracellular space; (iii) ...
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Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia Reoxygenated Neonatal Rat Cardiomyocytes
... The Ca2+ entry across the membrane through L-type Ca2+ channels is balanced by the efflux of Ca2+ from the cell via the NCX and PMCA1.36 In the present results, the density of L-type Ca2[r] ...
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Na+/Ca2+ exchange current in ventricular myocytes of fish heart: contribution to sarcolemmal Ca2+ influx
... ∫ICa µmol l−1, integrated Ca2+ influx through L-type Ca2+ channels; ∫IEx µmol l−1, integrated Ca2+ influx through reverse Na+/Ca2+ exchange; ∫Iit, integrated Ca2+ efflux through forward [r] ...
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