Cadherin 11
<p><em>Cadherin-11</em> is inactivated due to promoter methylation and functions in colorectal cancer as a tumour suppressor</p>
... Background: The cadherin-11 (CDH11, OB-cadherin) gene is a member of the cadherin family and is located on chromosome 16q22.1. Previous studies have revealed that cadherins play signi fi cant ...
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Stromal cell cadherin 11 regulates adipose tissue inflammation and diabetes
... cell cadherin-11 might offer a new thera- peutic approach for obesity-induced glucose ...anti– cadherin-11–specific Ab (SYN12) treatment in HFD-fed WT mice significantly improved glucose ...
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Building the synovium: cadherin 11 mediates fibroblast like synoviocyte cell to cell adhesion
... of cadherin-11 expression by FLSs provides further insight into mechanisms of synovial lining formation and structural organization and integrity ...of cadherin-11 probably provide a molecular ...
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Evidence for cadherin 11 cleavage in the synovium and partial characterization of its mechanism
... recombinant cadherin-11 extracellular domain Fc protein activated multiple signaling pathways in synovial fibroblasts, inducing expression of IL- 6 and other mediators important in RA pathogenesis (see ...
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Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction
... Figure 11). This defect in CF contractility and other reported effects of the permanent global knockout of Figure 6. CDH11 blockade reduces inflammatory signaling and improves vascular maturity after MI. SYN0012 ...
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Original Article miR-128 suppresses bleomycin-induced pulmonary fibrosis and epithelial to mesenchymal transition by targeting Cadherin-11
... TRIZOL Reagent (Invitrogen; Carlsbad, CA) was used to extract total RNA. The Reverse Transcription Kit (Takara; Dalian, China) was used to synthesize the cDNA. Quantitative RT-PCR (qRT-PCR) analyses were performed using ...
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The role and function of cadherins in the mammary gland
... N- cadherin and cadherin-11 both have recently been identi- fi ed to interact with the FGF signaling pathway by bind- ing to FGFRs and sustaining the FGF signal by prevent ing the internaliza tion of ...
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Novel markers for detection of CTCs without EpCAM expression
... The intention was to use Cadherin-11 as a mesenchymal antibody, next to Vimentin. An unconjugated version of Cad11, donated to the lab by a research group in Nijmegen, was chosen for this purpose. The ...
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PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis
... were blocked for 1 h with 5% BSA in Tris-buffered saline (TBS) at room temperature and then incubated overnight at 4 °C with anti-Cadherin-11 (1:1500 dilution, Abcam, Cambridge, MA, USA), anti-Akt (1:2000 ...
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Adhesion molecules of detrusor muscle cells are influenced by a hypercholesterolemic diet or bladder outlet obstruction in a wistar rat model
... no cadherin or catenin ex- pression levels were observed by immunohistochemistry in the detrusor muscle cells of DO and BOO patients, and concluded that such CAMs are not involved in smooth muscle cell adhesion in ...
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The tumour associated glycoprotein podoplanin is expressed in fibroblast like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis
... Primary synovial cell cultures from patients with RA (n = 6) and patients with OA (n = 5) were trypsinised, resuspended in fluorescence-activated cell sorting buffer (5% HIFBS, 0.09% sodium azide and 0.5% ethylenedia- ...
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Original Article Expression of E-cadherin and vimentin in oral squamous cell carcinoma
... Abstract: The aim of the study is to determine the levels of E-cadherin, vimentin expression in tumor tissues from patients with oral squamous cell carcinoma (OSCC), and the relationship between the expression of ...
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IrreC/rst mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE cadherin
... Although it is evident that DE-cadherin plays a crucial role in the accumulation of IrreC-rst at the adherens junctions, other mechanisms are required to explain the asymmetric localisation and restriction of the ...
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The assembly of developing motor neurons depends on an interplay between spontaneous activity, type II cadherins and gap junctions
... A core structural and functional motif of the vertebrate central nervous system is discrete clusters of neurons or ‘ nuclei ’ . Yet the developmental mechanisms underlying this fundamental mode of organisation are ...
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Forkhead box K2 inhibits the proliferation, migration, and invasion of human glioma cells and predicts a favorable prognosis
... Antibodies for FOXK2 (1:1,000), E-cadherin (1:1,000), N-cadherin (1:1,000), and vimentin (1:1,000) (Abcam) were used for the Western blot analysis. Total RNA was isolated with TRIzol (Invitrogen, Thermo ...
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Cadherin 7 and cadherin 6B differentially regulate the growth, branching and guidance of cranial motor axons
... The branchiomotor (BM) subset of cranial motoneurons is born in columns adjacent to the floor plate at Hamburger and Hamilton stage 14 [embryonic day (E) 2.5] (Hamburger and Hamilton, 1992; Varela-Echavarria et al., ...
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E Cadherin Dysfunction and Cancer
... Recently, we have implemented a murine model of colorectal cancer (CRC), in which four weeks post-induction, it is verified a slight increase of E-cadherin mRNA level, a significant decrease of β -catenin mRNA ...
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Original Article Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy
... cant pathological change tends to spare the subendocardium and gets involved segmental- ly. In addition, the significant change tends to be distinct in relatively the advanced stage of ARVC and be not well observed in ...
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Replacement of E cadherin by N cadherin in the mammary gland leads to fibrocystic changes and tumor formation
... Figure 2 Ncadk.i. mammary glands exhibit signs of precocious involution. (A) Immunofluorescence of paraffin sections revealed a mislocalization of N-cad in collapsed alveoli of Ncadk.i. mammary glands. No E-cad could be ...
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<p>Lipase member H is a downstream molecular target of hypoxia inducible factor-1α and promotes papillary thyroid carcinoma cell migration in BCPAP and KTC-1 cell lines</p>
... Cells were disrupted by RIPA Lysis Buffer (Beyotime) and scraped off the plate surface with a cell scraper. Protein concentration was measured using an enhanced BCA Protein Assay Kit (Beyotime). SDS-PAGE (10%) gels were ...
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