Caki-1
Expression of microRNA-30c via lentivirus vector inhibits the proliferation and enhances the sensitivity of highly aggressive ccRCC Caki-1 cells to anticancer agents
... ER α , miR-30c, and MTA-1 in endometrial cancer. Thus, it is valuable to declare whether miR-30c modulates highly aggres- sive ccRCC cell line proliferation and metastasis via MTA-1 and the potential ...
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Thyroid hormone – triiodothyronine – has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) – role of E2F4, E2F5 and p107, p130
... It is known that proximal tubules proliferate slower than ccRCC derived cells [22], therefore HK2, Caki-2 and Caki- 1 proved to be a proper cellular model for investigation of differences in cell ...
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Comparative Response of SC CAKI 1 Renal Tumor to Treatment with Doxorubicin HCl and Doxorubicin Orotate
... Each mouse was implanted s.c.in the right flank with a 30 - 40 mg fragment of CAKI-1 human renal tumor xe- nograft from an in vivo passage using a 13 gauge trocar needle. The day of tumor implantation was ...
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<p>LncRNA GA-Binding Protein Transcription Factor Subunit Beta-1 Antisense RNA 1 Inhibits Renal Carcinoma Growth Through an MiR-1246/Phosphoenolpyruvate Carboxykinase 1 Pathway</p>
... and caki-1 ccRCC cell lines were transfected with GA-binding protein transcription factor subunit beta-1 antisense RNA 1 (GABPB1-AS1), miR- 1246, or small interfering RNA phosphoenolpyruvate ...
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Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
... adding Caki-1 to the TNF-alpha stimulated HUVEC evoked a significantly diminished endothelial ICAM-1, VCAM-1 and E-selectin expression, compared to HUVEC not influenced by ...
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The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma
... treated Caki-1 cells transfected with siPFKP1 with 1 mM FBP and found that intracellular FBP level was restored (Supplementary Figure ...parental Caki- 1 cells (Supplementary Figure ...
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Anti-proliferative potential of Glucosamine in renal cancer cells via inducing cell cycle arrest at G0/G1 phase
... Results: Our data showed that Glucosamine significantly inhibited the proliferation of renal cancer 786-O and Caki-1 cells in a dose-dependent manner. Besides, Glucosamine treatment resulted in cell cycle ...
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Original Article MiR-22 functions as a biomarker and regulates cell proliferation, cycle, apoptosis, migration and invasion in renal cell carcinoma
... inhibited Caki-1 cell proliferation, colony forma- tion, cell motility, migration and invasion, as well as induced cell cycle arrest and promoted apoptosis in RCC cells, while blockage of miR- 22 reversed ...
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<p>Suppressed OGT expression inhibits cell proliferation and modulates EGFR expression in renal cell carcinoma</p>
... First, we examined O-GlcNAc modification levels and OGT expression in human RCC (786-O, ACHN, CAKI-1, and A498) cell lines compared with the human normal renal tubular epithelial HK-2 cell line. Total ...
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miR-96 suppresses renal cell carcinoma invasion via downregulation of Ezrin expression
... in Caki-1 and 786-O cells transfected with a miR-96 mimic or inhibitor using wound healing assays, Transwell assays and western ...in Caki-1compared to786-O cells. The invasive ability of ...
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Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma
... or Caki-1 cell lines have stem cell behav- ior, the soft agar colony formation assay, sphere- forming assay, invasion and migration by transwell assay, drug sensitivity by MTT assay and tumorigen- icity ...
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In vitro antitumor effects of AHR ligands aminoflavone (AFP 464) and benzothiazole (5F 203) in human renal carcinoma cells
... B) 5F 203 wound healing assay: TK10, SN12C, Caki-1 and ACHN cells were incubated with 5F 203 for 24 h with the dilutions shown described in the methodology. A wound was made with a yellow tip; the initial ...
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<p>Co-Expression Network Analysis Identified LTF in Association with Metastasis Risk and Prognosis in Clear Cell Renal Cell Carcinoma</p>
... and Caki-1 were purchased from the Cell Bank of Type Culture Collection (CBTCC, Chinese academy of science, Shanghai, China) and Cell Bank of Wuhan ...and 1% penicillin/streptomycin solu- tion ...
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Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway
... and Caki-1 cells were seeded in six-well ...and caki-1 cells were treated with indicated doses of PD for 24 hours, and then subjected to invasion ...and caki-1 cells were treated ...
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Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells
... In Caki-1 and ACHN cells the combination of panobi- nostat and bortezomib not only caused ubiquitinated pro- tein accumulation but also enhanced histone ...In Caki-1 and ACHN cells, HDAC ...
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... in Caki-1 and 786-O ...domains 1 (UHRF1) was directly suppressed by miR-101 in RCC cells, and overexpression of UHRF1 was confirmed in sunitinib-treated RCC ...
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Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF- 1/ p38/HSP27 signaling in renal cell carcinoma
... the caki-1 and caki-2 were seeded in 6-well plates at 40% confluence on the day before ...infect caki-1 and caki-2 cells at a multiplicity of infection (MOI) of ...
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Cripto-1 expression in patients with clear cell renal cell carcinoma is associated with poor disease outcome
... Fig. 1 CR-1 expression is significantly up-regulated in ccRCC cells and tissues and high CR-1 expression predicts poor ...and Caki-1) and human normal renal proximal tubule epithelial ...
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<p>miR-1-3p suppresses the epithelial-mesenchymal transition property in renal cell cancer by downregulating Fibronectin 1</p>
... Fibronectin 1, a tumor promoter and important EMT marker, is known to regulate the invasion and migration in cancer ...Fibronectin 1 (Figure 4A). To explore whether Fibronectin 1 was a functional ...
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Expression of miR-27a-3p is an independent predictive factor for recurrence in clear cell renal cell carcinoma
... and Caki-1 ...in Caki- 1 cells, and that a mimic of miR-27a-3p significantly increased cell proliferation, migration and invasion abilities in 786-O ...
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