Calcium Overload
Effects of Cornus Officinal Is Total Glycoside on Cardiomyocyte Apoptosis and Calcium Overload after Hypoxia/Reoxygenation Injury in Rats
... diomyocyte apoptosis [18]. Our study indicated that pretreatment with mid- dle-dose and high-dose of Cornus officinalis Total Glycosides can block H/R-induced calcium overload of myocardial cells. By ...
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Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction
... perpetuation of osteoarthritic cartilage destruction [26, 27]. As a key inflammatory factor, IL-1β has been widely used as a chondrocyte apoptosis-inducing agent simulat- ing the inflammatory environment of OA in vitro ...
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Spautin-1 Ameliorates Acute Pancreatitis via inhibiting impaired Autophagy and Alleviating Calcium Overload
... Acute pancreatitis is characterized by zymogen preactivation. Severe inflammation caused by zymogen activation can eventually lead to multiple organ dysfunctions which contribute to the high mortality rate of severe ...
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Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts
... accumulation indicative of glycolytic inhibition. To measure [Ca2+]i, fluorine NMR spectra were acquired in a separate group of hearts loaded with the Ca2+ indicator 5F-BAPTA [5,5'- difluoro derivative of ...
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Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation
... 9. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective ...
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Pathophysiology and pathogenesis of stunned myocardium Depressed Ca2+ activation of contraction as a consequence of reperfusion induced cellular calcium overload in ferret hearts
... intracellular free [Ca2+] transient during each beat, a decrease in maximal Ca2+-activated force, or a shift in myofilament Ca2+ sensitivity. We measured developed pressure (DP) at several [Ca]0 (0.5-7.5 mM) in ...
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Sodium/calcium exchange modulates intracellular calcium overload during posthypoxic reoxygenation in mammalian working myocardium Evidence from aequorin loaded ferret ventricular muscles
... We tested the hypothesis that the intracellular Ca2+ overload of ventricular myocardium during the period of posthypoxic reoxygenation is mediated by transsarcolemmal Ca2+ influx via Na+/Ca2+ exchange. In ...
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PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
... 2+ overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic ...2+ overload and mitochondrial de- polarization in PINK1 knockout neurons, thereby enhancing ...
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Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors
... we have shown higher levels of SERCA2 and SERCA3 proteins in GLC cells. Interestingly, an increase in SERCA2 expression was also observed after induction of the endoplasmic reticulum stress response in the neuroendocrine ...
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Effect of Sodium 2,3-Dimercaptopropane-1-Sulphonate (DMPS) on Chronic Daunorubicin Toxicity in Rabbits: Comparison with Dexrazoxane
... of calcium and a sig- nificant decrease in potassium and magnesium concen- ...decreased calcium concentration by more than one third as compared to the controls, tended to decrease potassium and magnesium ...
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CLINICAL UPDATES ON DRUG – INDUCED CARDIOTOXICITY
... cardiotoxicity. Calcium channel blockers, antiarrhythmic and beta receptor antagonist aggravate cardiac heart failure (CHF) and left ventricular ...ischemia, calcium overload, oxidative stress, ...
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Effects of "Fit" on Email Overload
... Email overload has been the subject of much study because it is a theoretically interesting phenomenon in its adverse effects on key job aspects, such as job burnout, work overload, productivity, and job ...
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In Transfusion-dependent Thalassemia, Increased Iron Overload is Associated with Lower Serum Alpha-klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations
... Univariate GLM analysis showed that (after controlling for age and sex) α-Klotho was significantly (F=8.24, df=1/86, p=0.005) lower in TDT (mean ±SE=344.9 ±32.7 pg/mL) than in normal control children (508.9 ±46.5 pg/mL). ...
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Reference Dependence and Choice Overload
... This paper offers an explanation for choice overload based on reference- dependent preferences. We assume that consumers construct an ideal object that combines the best attributes of all objects in their choice ...
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Tackling uncertainty in long-term predictions for host overload and underload detection in cloud computing
... Dynamic workloads in cloud computing can be managed through live migration of virtual machines from overloaded or underloaded hosts to other hosts to save energy and/or mitigate performance-related Service Level ...
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Energy aware virtual machine consolidation for cloud data centers
... an overload detection policy called Mn which uses the mean to predict the upper threshold and VM selection policy, called MBW, based on the maximum requested ...
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Do pregnancies reduce iron overload in HFE hemochromatosis women? results from an observational prospective study
... Current experimental data suggest that other factors such as hormonal factors may explain the difference in disease expression observed between men and women. Recent findings revealed that the gender difference ob- ...
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Endoplasmic reticulum–mitochondria crosstalk in NIX mediated murine cell death
... ER/SR calcium stores are proportional to the level of expressed ...SR calcium content of Nix-null mice restored sensitivity to cell death and reestablished ...and calcium-mediated signals for ...
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Has IFRS resulted in information overload?
... The move to NZ IFRS has been surrounded by complaints of too much information being provided. This is not simply a matter of the cost of providing the information, but the possibility of data overload. Data ...
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Striking the target in iron overload disorders
... iron overload in a mouse model of HFE-associated hemochromatosis (HFE- HH), the most common inherited form of hemochromatosis resulting from muta- tion in the HFE gene ...
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