cancer cell proliferation suppression
Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A
... A derived question from the current work is the identity of the kinase that phosphorylates Cdc25A, leading to its degradation. It has been described that Chk1 phosphorylates multiple residues on Cdc25A, among which, ...
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Suppression of CCT3 inhibits the proliferation and migration in breast cancer cells
... from Cell Signaling Technology (Dan- vers, MA, USA); and antibodies against CDH2, MMP2, FN1, MYC, p-mTOR and AKT1 were purchased from Abcam (Cambridge, MA, ...
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Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway
... After fixed with 10% formaldehyde for 12 h, tumor sam- ples were processed conventionally for paraffin-embedded tumor slides. The slides were subjected to antigen retrieval and the endogenous peroxidase activity was ...
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Jumonji domain-containing protein 1A promotes cell growth and progression via transactivation of c-Myc expression and predicts a poor prognosis in cervical cancer
... cervical cancer cells and tissues, and that suppression of JMJD1A inhibits proliferation, migration, and invasion of cervical cancer ...cervical cancer growth and ...
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Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach
... human cancer or endothelial cells, we determined the effects of RXRα silence by specific siRNA on DW22- mediated suppression of cell proliferation, migration, invasion, tube formation, and ...
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Original Article MiR-548c inhibits lung cancer cell proliferation through suppression of Galectin-3-mediated TLR4 signaling pathway
... Galectin-3, a member of the Galectin family, is a multifunctionalprotein [17]. Recently, compel- ling evidence has pointed out that Galectin-3 is involved in many physical and pathologic pro- cess, and is closely ...
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Suppression of microRNA-629 enhances sensitivity of cervical cancer cells to 1′S-1′-acetoxychavicol acetate via regulating RSU1
... cervical cancer cell lines. Suppression of miR-629 increased sensitivity toward ACA by reducing cell proliferation and inducing ...
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Anti-cancer effects of ginsenoside compound k on pediatric acute myeloid leukemia cells
... AML cell lines in a time- and dose-dependent ...to suppression of DNA synthesis during cell ...G1 cell cycle arrest and apoptosis induced by compound ...
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Paired box 5 is a novel marker of breast cancers that is frequently downregulated by methylation
... breast cancer is important for both diagnosis and the design of treatment ...various cancer types, where it is silenced by ...breast cancer requires further study, and the relationship between PAX5 ...
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RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression
... activated cell sorting (FACS) from lamina propria and CAC adenomas revealed that macrophages and dendritic cells were the major RIP3 producers during CAC growth, followed by T cells (Figure ...colorectal ...
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<p>Nanoformulated Bioactive Compounds Derived from Different Natural Products Combat Pancreatic Cancer Cell Proliferation</p>
... rapid suppression of pancreatic cancer cell viability/prolifera- tion within 24 hrs, while the non-encapsulated EA and DIM did not show any signi fi cant effect at 1 ...greater suppression of ...
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RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
... phase cell cycle regulation protein expression was decreased in the HCT-116 cells of RASAL1 overexpression compared with that of control group in a dose-dependent manner, but show no effect on the G2/M and S phase ...
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Original Article microRNA-214 inhibits the proliferation of non-small cell lung cancer via the suppression of IRS1
... blocking with 5% non-fat milk, the blots were incubated with primary antibodies (Abcam) at 4°C overnight, then the membranes were Figure 1. miR-214 is decreased in NSCLC tissues and cell lines. A. The expression ...
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A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells In Vitro
... in cancer is not thoroughly and may depend on the physiologic background of ...prostate cancer, CBP and p300 expression are associated the expression of androgen receptor ...decreased cell ...
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<p>Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells</p>
... therapeutic target for cancer suppression. Le fl unomide [N-(4-tri fl uoromethylphenyl)-5-methylisoxazol-4-carboxa- mide] is a widely used immunomodulatory drug, approved for the treatment of rheumatoid ...
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Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
... T cell activity in co-culture, and importantly, T cell proliferation can be restored either by restoring ar- ginine to the media or by the addition of an arginase in- hibitor, showing that arginase ...
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Knockdown of SETDB1 inhibits breast cancer progression by miR-381-3p-related regulation
... of cell proliferation, cell cycle progression and migration, ...breast cancer tissues and cell lines, and SETDB1 depletion led to a suppression of cell ...
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Synergy between molecular biology and imaging science toward mechanism based biomarkers associated with prostate cancer
... Prostate cancer is a heterogeneous disease with sub- types that are characterized by different molecular profiles as a result of chromosomal rearrangements, epigenetic modifications, and activation of various ...
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Metabolic requirements for cancer cell proliferation
... in cancer cells [87] (and largely a result of the assigned lower bound for lactate ...targeting cancer cell metabol- ism, which suggests that combination treatments that minimize the likelihood of ...
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The effects of lncRNA MALAT1 on proliferation, invasion and migration in colorectal cancer through regulating SOX9
... DLD-1 and HT-29 cells transfected with si-MALAT1, miR-145 inhibitor, si-MALAT1 + miR-145 inhibitor, si- SOX9, pcDNA3.1-SOX9, si-SOX9 + miR-145 inhibitor were obtained. Cells were digested by trypsin solution and then ...
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