cancer genomics
Cancer Genomics and Biology 2015 – Meeting Report
... Asian Cancer Genomics and their implication in our understanding and management of human cancer by ...National Cancer Center ...relevant cancer genomic questions using the appropriate ...
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Perspective beyond Cancer Genomics: Bioenergetics of Cancer Stem Cells
... that cancer is a disease caused by genetic and epigenetic alterations is now widely accepted, perhaps more emphasis has been given to the fact that cancer is a genetic ...of cancer disaster as the ...
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OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics
... teaching cancer genomics to biomedical students, a crit- ical component of which is that it allows students to contribute to the broader scientific community in the form of a new web-based learning tool ...
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The global cancer genomics consortium's third annual symposium: from oncogenomics to cancer care
... breast cancer genomics and transcriptomics: where do we stand?; 2) current application of genomics in cancer therapy; 3) genomic approaches to facilitate biomarkers discovery and drug ...
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Visualizing multidimensional cancer genomics data
... Genome browser tools in general have limited capacity to display relationships between genomic features that are independent of location, such as the coordinated expression of genes. The IGV and UCSC Cancer ...
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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
... of genomics. It seems fitting to call the conclusion of The Cancer Genome Atlas (TCGA) the end of the beginning of cancer ...large-scale genomics-based cancer research, with its ...
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Toward better benchmarking: challenge based methods assessment in cancer genomics
... As the profile of the results of benchmarking studies increases, it is becoming increasingly clear that bench- marking itself is a serious scientific endeavor. The design of a challenge is non-trivial and in some ways is ...
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New concepts in breast cancer genomics and genetics
... of cancer genomics at the level of DNA and RNA is that conclusions regard- ing pathway activation are indirect since proteins, not nucleic acids, execute these ...the cancer cells in less biased ways ...
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Cancer genomics: one cell at a time
... Intratumor heterogeneity has been widely reported in many human cancer types [7,8,30] and confounds the clinical diagnosis and therapeutic targeting of tumors. Intratumor heterogeneity is generally viewed as ‘bad ...
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Pancreatic cancer genomics: insights and opportunities for clinical translation
... pancreatic cancer: KRAS, CDKN2A, TP53, and SMAD4 (Table 2); these are referred to as ‘driver’ ...pancreatic cancer, occurring by intra genic mutation in association with allelic loss, homozy gous ...
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Sensitivity to sequencing depth in single-cell cancer genomics
... Nevertheless, several technical challenges surrounding current SC-Seq methodologies greatly limit our ability to obtain reliable genomic information from single cells. For instance, the multiple rounds of whole genome ...
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Exploiting cancer genomics in pet animals to gain advantage for personalized medicine decisions
... of cancer patients, due to unpre- dictability, in many cases, follow-up and response to adjuvant ...the cancer therapy needs to change to a more personalized approach, in which each patient is treated ...
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Computational methods for personalized cancer genomics
... Breast Cancer International Consortium (METABRIC) found that the PAM50 “Luminal A” and “Luminal B” subtypes could be further divided in significant subtypes using Item Cluster Analysis (iClust) ...The ...
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The translation of cancer genomics: time for a revolution in clinical cancer care
... checkpoint blockade agents that invoke the immune system’s interaction with cancer cells [32-36]. In a new paradigm, NGS identifies tumor-specific mutations and their RNA expression levels, and these data are used ...
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The global cancer genomics consortium’s symposium: new era of molecular medicine and epigenetic cancer medicine - cross section of genomics and epigenetics
... The theme was introduced by the opening conference lecture by Dr. Akihiko Yokoyama from the Laboratory of Malignancy Control Research, Kyoto University School of Medicine. Dr. Yokoyama presented new molecular insights by ...
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Whither genomics?
... of genomics affect the balance between small and big science? Small science will adapt and ...on genomics as a way to devise clever, new approaches to old and difficult ...where genomics is ...Will ...
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Genomics and the Law
... disclaimers on their website and consent forms with the aim to inform consumers of the limitations of the tests that they are providing as well as to give themselves some protection from liability. In countries such as ...
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Governance in genomics: a conceptual challenge for public health genomics law
... To date, the idea of public health is most likely be detected in prenatal and newborn testing but further extension to other (multifactoriell) diseases like adipositas seems inevitable. This further extension is likely ...
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Application of resequencing to rice genomics, functional genomics and evolutionary analysis
... and domestication processes, even in cultivars improve- ment. The resequencing-based method shows a series of obvious advantages; it is approximately 20-times faster in terms of data collection and 35-times more precise ...
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Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer
... Breast cancer has been hypothesized to develop through a linear histological progression from hyperplasia and in situ carcinoma to invasive cancer, a progression model that is possibly similar to that ...
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