cancer stem cell (CSC).
Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors
... The CSC hypothesis proposes bi-directional inter-conversion between stem and non-stem compart- ments in order to sustain tumorigenesis and establish multi-lineage differentiation into different tumor ...
16
Expression of intestinal stem cell and cancer stem cell markers in submucosal invasion and its prognostic significance in gastric cancers
... The cancer stem cell (CSC) model suggests that tumor growth is induced by a small group of self- sustaining cells with longevity, infinite proliferation, and the ability to differentiate into ...
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The significance of Cancer stem cell markers’ gene expression and Relevance for Survival Outcomes
... target cancer cells, but recent data suggest the presence of cancer stem cells as cells with self-renewal and tumorigenic ...abilities. Cancer stem cell markers have been ...
23
Discovery of selective, antimetastatic and anti cancer stem cell metallohelices via post assembly modification
... of cancer cell lines, with enantioselectivity reected in cell cycle studies, plus enhanced selectivity with respect to a panel of non-cancer cell lines in ...of cell migration, ...
11
Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation
... them, cancer stem cells are known to contribute to tumor vasculogenesis through their direct endothelial ...of cancer stem cells derived from breast and renal ...of cancer stem ...
15
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs
... in cancer stem cell biology ([27, 67, 69–71] and see ...prostate cancer stem cell expansion ...of stem cell potential, wherein formation of secondary mammo- spheres ...
24
Original Article Expression of cancer stem cell markers and epithelial-mesenchymal transition-related factors in anaplastic thyroid carcinoma
... the stem cell properties induced by the epithelial-mesenchymal transition (EMT) was one of reasons for the dismal outcome of ...of cancer stem cells and EMT-activating transcriptional ...
9
Oncolytic viruses as immunotherapy: progress and remaining challenges
... include cancer stem cell (CSC) lysis and autophagy, modulation of innate and adaptive immunity, immunogenic cell death (ICD), OV transgene arming for improved clinical efficacy, inhi- ...
11
Original Article Over-expression of BMI1 is associated with favorable prognosis in cervical cancer
... B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), is a Plycomb group (PCG) protein, that is involved in the epithelial-mesenchymal transition (EMT) and induces stem cell ...
9
Hematopoietic stem cells and retroviral infection
... Leukemia Stem Cells/Cancer Stem Cells (LSC/CSC) The cancer stem cell hypothesis postulates that cancer can be initiated, sustained and maintained by a small number ...
17
Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma
... B cell hematological malignancies has demonstrated the potency of this approach for cancer immunotherapy [6–9], and CAR T cells targeting a variety of different hematologic and solid tumor antigens are ...
11
New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
... CAF: cancer associated fibroblasts; CEA: carcinoembryonic antigen; CSC: cancer stem cell; CSCC: cutaneous squamous cell carcinoma; CT: cytoplasmic tail; CTLA-4: cytotoxic T ...
13
Decreasing glioma recurrence through adjuvant cancer stem cell inhibition
... Figure 2 Neural precursor compartments and brain cancer. A) The mature adult brain contains remnant populations of undifferentiated NSCs in the dentate gyrus and subventricular zone (center panel). (i) Agents ...
6
Molecular characterization and targeted therapeutic approaches in breast cancer
... breast cancer (BC) detection and adjuvant treatment, BC is still responsible for approximately 40,000 deaths annually in the United ...of cancer stem cell-targeted therapies and immune ...
11
Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells
... T cell receptor signaling chain ...T cell signaling/ costimulatory domains, including improved antitumor ac- tivity and prolonged survival of modified T cells, will con- tinue to be explored ...tumor ...
11
Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis
... Metastatic CSC (mCSC) are unique in their own intricacy, intravasation of disseminated cancer cells from its primary source of origin, extravasation into different organs and covert colonization after a ...
17
L-Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents
... target CSC and decrease their survival and self-renewal is not restricted to the TUBO model, since similar results were obtained with MDA-MB-231 cells (Figure 6E- ...undifferentiated stem and progenitor ...
15
Lung cancer stem cells and low-intensity laser irradiation: a potential future therapy?
... Lung cancer is one of the prime causes of cancer mortal- ity worldwide because of its metastatic properties [2] and potential for ...that cancer stem cells (CSCs), found in solid tumors, may ...
8
Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena
... the cell nucleus, and exhibit lower evolutionary conservation and lower expression level than mRNAs [14, 16, ...regulation, cell cycle control, nuclear and cytoplasmic trafficking, tran- scription, ...
19
Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
... targeted cancer therapies assumes that some tumors have metabolic preferences and vulnerabil- ities that distinguish them from normal ...tumor cell subtype at relapse [5] and are associated with the worst ...
11