candidate gene association
A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population
... wide association studies (GWAS) and candidate gene association studies are the two robust approaches to investigate correlation between genetic variation and disease risk to identify genome ...
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Candidate gene association studies and risk of Hodgkin lymphoma: a systematic review and meta-analysis.
... exclude candidate gene association studies exploring the human leucocyte antigen (HLA) region and HL given the already established predisposition at the HLA region(5) and the complex LD structure ...
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Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate gene association study
... the association between NOS3 variants and preeclampsia have produced controversial or inconclusive results and the replication record of these studies is relatively poor ...of association for the NOS3 ...
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Systematic review and meta analysis of candidate gene association studies of lower urinary tract symptoms in men
... The rs5030739 polymorphism of ELAC2 was one of the earliest candidates as a prostate cancer risk SNP [32]. Four studies investigated an association of rs5030739 with symptomatic BPH [33–36]. However, the risk SNP ...
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Optimal Designs for Linkage Disequilibrium Mapping and Candidate Gene Association Tests in Livestock Populations
... yielding the highest rate of correct QTL positioning the frequency for correct positioning of the QTL was nearly three times greater for STD than for RAN (48.8 differed across combinatio[r] ...
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Variation in endoglin pathway genes is associated with preeclampsia: a case–control candidate gene association study
... Are the pathway associations we have demonstrated biologically plausible? Although we do not know the functional consequences of these associations, several explanations could account for the association between ...
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Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility
... from candidate gene-association studies on adults, the possibility of false-positive findings was considered by providing the reference p value for an experiment-wide significance with Bonferroni ...
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Carotid Artery Atherosclerosis: A Review on Heritability and Genetics
... exact gene variations have been conducted via linkage analysis, candidate gene associ- ation studies, and ...emphasized. Candidate gene association studies depend heavily on the ...
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IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population
... Genetic association analysis has suggested that IMPA2 is a susceptibility gene for ischemic stroke ...the association between IMPA2 polymorphisms and the risk of IS in a Han Chinese population, ...
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An assessment of the Irish population for large scale genetic mapping studies involving epilepsy and other complex diseases
... particular gene or region, or, indeed, the entire set of common variants genotyped by the HapMap ...genetic association studies and influences SNP selection in candi- date gene studies, as well as ...
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An update on vitamin B12-related gene polymorphisms and B12 status
... a candidate gene association study of 613 Irish men, a significant association was observed between the SNP rs1801198 and serum vitamin B12 levels (P = ...TCN2 gene (rs757874, ...
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Genetics of venous thrombosis: insights from a new genome wide association study
... a candidate gene association analysis using less stringent statistical ...of association with the disease were then planned to be further tested for replication in independent case-controls ...
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The genetic and epigenetic landscapes of the epithelium in asthma
... and candidate gene association studies to genome-wide association studies and whole genome sequencing, and epigenetic factors; DNA methylation, histone modifications, and non-coding RNAs ...
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Family-based study of association between MAFB gene polymorphisms and NSCL/P among Western Han Chinese population
... NSCL/P is complex congenital craniofacial defect with serious malformations, including malocclusion, oral and nasal dysfunction. Though there has been great progress made in surgical repair, these malformations still ...
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Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
... 23. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, ...
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Common breast cancer risk variants in the post COGS era: a comprehensive review
... a candidate gene ap- ...many candidate gene studies, the frequencies of the three genotypes at a given candidate locus are assayed in population-based breast cancer cases and matched ...
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QTL mapping and candidate gene analysis of peduncle vascular bundle related traits in rice by genome-wide association study
... SPIKE gene increases grain yield of indica rice through enlarging sink size, source size, and translocation ...APO1 gene controlling the number of primary rachis branches also controls the vascular bundle ...
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Genetic basis for personalized medicine in asthma
... The identification of those patients at risk from potential adverse effects of b 2 -adrenergic receptor agonists remains a critical clinical question, as does the targeting of this class of drug to those patients most ...
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Genome-wide association study and candidate gene analysis of alkalinity tolerance in japonica rice germplasm at the seedling stage
... two candidate genes, OsIRO3 contained a 7-bp deletion in the starting position of the 5’UTR that was sig- nificantly associated with the alkalinity-tolerant phenotype and thus was the most likely candidate ...
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Science review: Searching for gene candidates in acute lung injury
... complex gene–environment interactions, and strong potential for locus ...the candidate gene approach and an ortholog gene database to provide relevant gene ontologies and insights into ...
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