Carbapenems/meropenem
PubMedCentral-PMC5850634.pdf
... CRKp were defined as K. pneumoniae isolates with nonsus- ceptibility to any of the following carbapenems: meropenem, imipenem, or ertapenem, as outlined by the Clinical and Laboratory Standards Institute ...
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Treatment options for K. pneumoniae P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, colistin and tigecycline. An approach based on the mechanisms of resistance to carbapenems.
... of Meropenem- Vaborbactam Versus Best Available Therapy for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Patients Without Prior Antimicrobial Failure: A Post Hoc ...
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Clinical Outcomes of Enterobacteriaceae Infections Stratified by Carbapenem MICs
... The Clinical and Laboratory Standards Institute (CLSI) lowered the MIC breakpoints for meropenem and imipenem from 4 mg/ liter to 1 mg/liter for Enterobacteriaceae in 2010. The breakpoint change improves the ...
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Synergistic Combination of Carbapenems and Colistin against P aeruginosa and A baumannii
... to Carbapenems however sus- ceptible to Colistin except the strain A100 that was highly resistant to Colistin (Tables 1 and ...to Carbapenems were seen with the following strains P22, P20 and ...to ...
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PubMedCentral-PMC5365650.pdf
... infections due to KPC-Kp with elevated carbapenem MICs ( ⱖ 16 mg/liter) (10). Interestingly, rifampin-containing combination regimens to combat KPC-Kp have shown promise in preclinical animal models and some in vitro ...
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Heteroresistance to Meropenem in Carbapenem Susceptible Acinetobacter baumannii
... for carbapenems were determined, and the isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and sequence typing ...and meropenem for the native isolates ranged from ...and meropenem ...
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Fast Assessment of Resistance to Carbapenems and Ciprofloxacin of Clinical Strains of Acinetobacter baumannii
... with meropenem at 0, 4, 8, and 16 g/ml and with ciprofloxacin at 0, 1, 2, and 4 g/ml for 60 min, in a final volume of 30 ...with meropenem and at 37°C for those incubated with ...
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Bulgecin A as a β-lactam enhancer for carbapenem-resistant<em> Pseudomonas aeruginosa</em> and carbapenem-resistant <em>Acinetobacter baumannii</em> clinical isolates containing various resistance mechanisms
... to carbapenems in carbapenem-resistant PSDA (CR-PSDA) and carbapenem-resistant ACB, as well as ACB resistant to ...using meropenem, BlgA extract, and meropenem plus BlgA ...of meropenem, was ...
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Piperacillin–tazobactam as alternative to carbapenems for ICU patients
... of carbapenems raises concerns on the spread of carbapenem-resistant Enterobacteriaceae and specifically carbapenemase-pro- ducing Enterobacteriaceae (CPE) ...and meropenem [6, ...of carbapenems will ...
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Antimicrobial consumption in five adult intensive care units: a 33-month surveillance study
... gentamicin), carbapenems (imipenem or meropenem), cephalosporins (ceftriaxone, cefotaxime, ceftazidime, or cefepime), fluor- oquinolones (ciprofloxacin or norfloxacin), piptazocin (piperacillin/tazobactam), ...
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Case Report Treatment for severe infections due to carbapenem-resistant Klebsiella pneumoniae in pediatric patients: combination of fosfomycin with carbapenems
... with carbapenems-resistant Klebsiella pneumoniae infection occurred in pediatric intensive care ...bilirubin. Carbapenems were frequently used as the first choice such as imipenem and meropenem in ...
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Reevaluation of interpretive criteria for Haemophilus influenzae by using meropenem (10 microgram), imipenem (10 microgram), and ampicillin (2 and 10 microgram) disks
... The frequency of BLNAR strains has been reported to be very low (6, 15, 16). In a recent study from Canada (31) that assessed 1,400 H. influenzae isolates, only 0.4% of strains were categorized in the BLNAR group, while ...
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In Vitro Comparative Efficacy of Carbapenems and β-Lactam β-Lactamase Inhibitor Combinations Against Multi Drug Resistant Gram Negative Bacilli
... Results: From 4204 samples, 2413(57.39%) Gram-negative rods were isolated. These were Escherichia Coli 1039(43.0%), Pseudomonas aeruginosa 667(27.6%), Klebsiella pneumoniae 490(20.3%), Proteus 62(2.6%), Acinetobacter ...
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Phenotypic and Molecular Characteristics of Carbapenem Resistant Enterobacteriaceae in a Health Care System in Los Angeles, California, from 2011 to 2013
... Identification and inclusion of CRE from archived clinical isolates. Antimicrobial susceptibility test results for clinical isolates of Enterobac- terieaceae (i.e., from patient cultures, not surveillance specimens) from ...
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Click here to download PDF version of the article !
... Modified Hodge test has been effectively used for detection of carbapenemase production in Enterobacteriaceae. A positive result in MHT may indicate carbapenemase of diverse class viz. MBLs including New Delhi metallo ...
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A compilation of antimicrobial susceptibility data from a network of 13 Lebanese hospitals reflecting the national situation during 2015–2016
... from South Lebanon. Investigators reported high-level car- bapenem resistance in A. baumannii and P. aeruginosa, 88% (638/724 isolates) and 41% (760/1848 isolates), re- spectively [6]. Ninety percent of the ...
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The role of carbapenems in initial therapy for serious Gram negative infections
... Synthesis of β -lactamases by Gram-negative bacilli has become increasingly important in the development of resistance to carbapenems. Four classes of β -lactamases can produce carbapenem resistance (Table 1). ...
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Phylogeographic, genomic, and meropenem susceptibility analysis of Burkholderia ubonensis
... The bacterium Burkholderia ubonensis is commonly co-isolated from environmental speci- mens harbouring the melioidosis pathogen, Burkholderia pseudomallei. B. ubonensis has been reported in northern Australia and ...
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Solubility and Dissolution Enhancement of Meropenem by Nano Suspension Approach
... Emulsification solvent evaporation method was employed in the prepara- tion of nanosuspensions of meropenem, a poorly soluble drug. Changing the operation parameters such as sonication time and the concentration ...
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Characterization of antimicrobial resistance mechanisms in carbapenem-resistant <em>Pseudomonas aeruginosa</em> carrying IMP variants recovered from a Mexican Hospital
... Susceptibility to 13 anti-pseudomonal agents (piperacillin, ticarcillin, piperacillin/tazobactam, ceftazidime, cefepime, aztreonam, imipenem, meropenem, gentamicin, tobramycin, amikacin, ciprofloxacin, and ...
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