Cardiac allograft
RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection
... chronic cardiac allograft rejection presents as severe, diffuse vascular intimal hyperplasia involving the entire vessel wall, often resulting in compromised vascular flow and eventual ischemia, similar to ...
108
Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection
... term cardiac allograft survival was achieved by peri- transplant therapy with a CD4 mAb, proved resistant to development of transplant arteriosclerosis or other stigmata of chronic allograft ...
11
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival
... murine cardiac allograft recipients with MECA79-anti-CD3-NP resulted in significantly prolonged allograft survival in comparison with the control ...
18
Synergic silencing of costimulatory molecules prevents cardiac allograft rejection
... Gene silencing by using small interfering RNA (siRNA) is capable of specifically blocking gene expression in mamma- lian cells without triggering the nonspecific panic response [16,17]. The strategies of using siRNA have ...
11
Induction of myocardial nitric oxide synthase by cardiac allograft rejection
... during cardiac allograft rejection, hearts from Lewis or Wistar-Furth rats were transplanted into Lewis ...isolated cardiac myocytes from rejecting allogeneic grafts but not in tissue and myocytes ...
9
What is the optimal prophylaxis for treatment of cardiac allograft vasculopathy?
... Coronary artery disease in the transplanted heart, also known as cardiac allograft vasculopathy (CAV), is one of the major causes of mortality late after transplantation. It affects up to 50% of all heart ...
6
Deletion of Smad3 improves cardiac allograft rejection in mice
... allograft rejection as detected by a marked inhibition of the transcriptional factor RORγt and its signature cytokine IL-17A in the donor heart. In contrast, deletion of Smad3 promoted Th17 development with higher ...
15
CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis
... Heart transplantation is the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, the rate of transplanted graft loss remains substantial. Graft loss is primarily ...
92
Fox smell abrogates the effect of herbal odor to prolong mouse cardiac allograft survival
... Adoptive transfer studies were conducted to determine whether regulatory cells were generated by olfactory exposure to TJ-23. Thus, 30 days after CBA recipients (primary recipients) underwent transplantation of a B6 ...
8
Cardiac allograft immune activation: current perspectives
... Abstract: Heart transplant remains the most durable option for end-stage heart disease. Cardiac allograft immune activation and heart transplant rejection remain among the main complica- tions limiting ...
10
Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine treated monkeys
... attenuate cardiac allograft vasculopathy (CAV) (classic chronic rejection lesions found in transplanted hearts) in a translational model has not previously been ...
11
P2X7R mutation disrupts the NLRP3 mediated Th program and predicts poor cardiac allograft outcomes
... adverse cardiac events (MACEs) within 10 years after transplantation in 22 of 39 carriers ...in cardiac-trans- planted patients bearing the P2X7R mutant allele is associated with an increased risk of ...
15
Early Cardiac Allograft Vasculopathy: Are the Viruses to Blame?
... This paper describes a case of early (7 months after transplant) cardiac allograft vasculopathy. This-43-year-old (CMV positive, EBV negative) female patient underwent an orthotopic heart transplant with a ...
5
CD4 T cell–mediated cardiac allograft rejection requires donor but not host MHC class II
... of cardiac allografts in SCID ...of cardiac allografts rejected by purified CD4 T showed pronounced infiltration of CD4 T cells without detectable contaminating CD8 or B cells (Figure ...of cardiac ...
9
Cardiac retransplantation is an efficacious therapy for primary cardiac allograft failure
... for cardiac retransplants with residual tissue from the initial donor as well as a heart from a second ...experimental cardiac trans- plant models thus far fails to answer these ...of cardiac ...
5
Multiparametric cardiovascular magnetic resonance surveillance of acute cardiac allograft rejection and characterisation of transplantation associated myocardial injury: a pilot study
... There has been little previous investigation into temporal changes in allograft structure and function in the early phase post-transplant. Using echocardiography, Antunes et al. [24] found LV EF to improve ...
11
Targeted deletion of CX3CR1 reveals a role for fractalkine in cardiac allograft rejection
... With regard to the cardiovascular disease, Harrison et al. (7) reported that inflammatory agents, such as lipopolysaccharide and TNF-α, upregulated in vivo expression of Fk in rat aortic endothelial cells and car- diac ...
11
Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection
... is induced in activated T cells. PF4 in the supernatant was also increased compared with resting controls 4 days after T cell stimu- lation (Figure 6B). In addition, PMA-stimulated Jurkat T cells had increased CXCL4 and ...
11
Mitochondrial permeability regulates cardiac endothelial cell necroptosis and cardiac allograft rejection
... deficient cardiac allografts showed prolonged survival compared to wild-type C57BL/6 grafts post ...in cardiac allografts, and that Cyp-D can be an important therapeutic target for long-term graft ...
55
Platelet derived or soluble CD154 induces vascularized allograft rejection independent of cell bound CD154
... prevent allograft rejection, presumably by interrupting interactions between T cells and ...initiate cardiac allograft rejection independent of any cellular source of this ...reject cardiac ...
7