Cardiac repair
Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
... native repair mechanisms via administration of exogenous stem or progenitor cells (S/PCs) might provide fruitful approaches for reducing morbidity and mortality following myocardial ...endogenous cardiac ...
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Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview
... Figure 1. The main DDSs employed in recent years in the field of VEGF and cardiac repair are represented. In the particles (nano or microsized) VEGF can be included homogenously through the entire particle ...
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
... both respond to and secrete a variety of cytokines. Macrophages have been categorized into two major subtypes: pro-inflammatory M1 cells secrete mediators such as ROS which aggravate inflammation, while cells of the ...
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Improving Cardiac Repair by Stem Cell Factor Post-Myocardial Infarction
... Cardiosphere-derived cells (CDCs) are also CSCs identified through their ability to migrate from cultured cardiac tissues and form floating spheres. CDCs are isolated from minimally invasive percutaneous ...
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ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
... cardiac repair. ISL1-CPCs are a CPC population with authentic cardiac origin based on our previous detailed lineage tracing studies (9, ...intrinsic cardiac potential of hISL1- CPCs and ...
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Original Article Cardiomyogenic induced bone marrow c-kit cells improve cardiac repair in mice myocardium infarction model
... ing in ischemic cardiomyopathy [4, 5, 8, 9]. Hematopoietic stem cells expressing c-kit have the capacity to drive efficient cardiac repair via differentiation, neovascularisation, myogenesis and ...
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Unchain my heart: the scientific foundations of cardiac repair
... enhance cardiac repair came as an extrapolation of findings of results from efforts to increase EPC levels for neovascularization in another context — hind limb ...
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Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct
... improves cardiac recovery following MI in a mouse model of permanent ligation of the left ventricle descending coronary artery by affecting multiple cardiac cells to mediate ...in cardiac injury ...
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Bioactive scaffolds in stem-cell-based therapies for cardiac repair: protocol for a meta-analysis of randomized controlled preclinical trials in animal myocardial infarction models
... for cardiac repair over the past 18 years ...in cardiac function [8, ...the cardiac tissue [10, ...tissue repair [12–14], and implant this cell-scaffold structure into infarcted ...
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Triggering Endogenous Cardiac Repair and Regeneration via Extracellular Vesicle-Mediated Communication
... of cardiac repair, in either autologous as well as allogeneic ...host cardiac tissue by creating a responsive microenvironment, which is regulated by local concentration of secreted paracrine factors ...
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Antiinflammatory activity of ANGPTL4 facilitates macrophage polarization to induce cardiac repair
... in vitro (29). In nephrotic syndrome, elevated circulating ANGPTL4 protein in podocytes exerts a systemic feedback response against proteinuria and results in hypertriglyceridemia (30). In other studies, carriers of ...
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Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?
... acellular cardiac scaffolds that display preserved cardiac extracellular matrix ...ing cardiac function post ...from cardiac tissue ...
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Cardiac repair in a murine model of myocardial infarction with human induced pluripotent stem cell-derived cardiomyocytes
... tion in post-MI HF. ESCs and iPSCs are pluripotent stem cells that possess the ability to produce a sufficient amount of functional cardiomyocytes for “true” heart regeneration. Unlike ESCs, iPSCs are generated from an ...
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A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair
... Our model of doxorubicin-induced cardiomyopathy represents a well-characterized mouse model of myocardial dysfunction following chemotherapeutic treatment. In vivo delivery of circ-Amotl1 shows potential for further ...
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Guest-Host Interactions To Engineer Injectable Hydrogels With Controlled Degradation And Release For Cardiac Repair
... improved cardiac function and tissue morphology (scar fraction, capillary density) in hydrogels modified with VEGF as opposed to unmodified hydrogels, suggesting that immobilized proteins are also an effective ...
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Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium
... into cardiac progenitors ...of cardiac lineage-related genes through regulating the cardiac lineage factor ...in cardiac progenitor cell-derived regeneration, have yet to be thor- oughly ...
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Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction
... and their expanded progeny (cardiosphere-derived cells) uniformly express transforming growth factor receptor beta receptor (aka endoglin or CD105) [9, 10]. Therapeutic efficacy is difficult to predict using molecular ...
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Interleukin-6 Mediates Post-Infarct Repair by Cardiac Explant-Derived Stem Cells
... post-infarct repair by EDCs- irrespective of donor health ...therapeutic repair by EDCs from patients with multiple medical comorbidities and greater LTS score despite greater IL-6 production may be ...
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Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx
... Rosa laevigata Michx (RLM) is mainly distributed throughout the southeast and southwest China, belongs to the rosaceae. RLM is a traditional Chinese medicine that is commonly used to treat pelvic inflammation, diarrhea, ...
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Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy
... the cardiac regenerative window in the mammalian heart is restricted to the early postnatal ...proper cardiac regenerative ...following cardiac injury will help elucidate the cholinergic nerve ...
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