Cardiac toxicity
Cardiac Toxicity of Azole Antifungals
... of cardiac toxicity associated with ITZ inspired a review of the Adverse Event Reporting System (AERS) ...of cardiac toxicity were identified from the post-marketing reports ...
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Ameliorative Influence of Dietary Dates on Doxorubicin Induced Cardiac Toxicity
... induced cardiac tox- icity and cardiac remodeling in Wistar albino ...respectively). Cardiac remodeling and toxicity in the rats were induced by administra- tion of DXR ...on cardiac ...
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<p>Cardiac toxicity of immune-checkpoint inhibitors: a clinical case of nivolumab-induced myocarditis and review of the evidence and new challenges</p>
... particular, cardiac toxicity is a potentially fatal AE, and introduces new challenges regarding its underlying molecular mechanisms of occurrence, optimal treatment and follow up, and ...immune-mediated ...
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Protective effect of single or combined treatment of Moringa oleifera and Citrullus colocynthis on carbon tetrachloride induced hematological and cardiac toxicity in rats.
... Heart is a bio-vital organ that performed intense and continuous activity; therefore it has a less potent antioxidant system as compared with other organs (de Freitas et al., 2013). The endogenous protective mechanisms ...
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Protective effect of Sheng Mai Yin, a traditional Chinese preparation, against doxorubicin induced cardiac toxicity in rats
... gastrointestinal toxicity and kansui-induced hepatocyte cytotoxicity [11, ...induced cardiac toxicity ...electrocardiogram, cardiac func- tion and myocardial fibrosis analysis were ...
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Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: A randomized controlled double blind study
... Background: Cardiac toxicity due to ingestion of oleander plant seeds in Sri Lanka and some other South Asian countries is very common. At present symptomatic oleander seed poisoning carries a mortality of ...
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The protective role of manganese superoxide dismutase against adriamycin induced acute cardiac toxicity in transgenic mice
... ADR-induced cardiac toxicity (1, 8, 16–19), addi- tional subcellular alterations including intracytoplasmic vacuoles, dilated sarcoplasmic reticulum, and myofibril disar- ray have also been identified ...
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More than 9 years of continuous trastuzumab treatment in metastatic breast cancer without cardiac toxicity: a case report and literature review
... In the absence of a randomized, prospective study address- ing directly the different factors associated with LTS, a case to case risk-benefit analysis, taking into consideration the prognostic of the individual patient ...
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Lipid emulsion injection-induced reversal of cardiac toxicity and acceleration of emergence from general anesthesia after scalp infiltration of a local anesthetic: a case report
... Systemic Toxicity has stated that “The practitioner’s vigilance is of critical importance in recognizing early signs of LAST (CNS depression [coma, respiratory arrest] and cardiac excitation [PVCs and ...
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Doxorubicin-loaded dextran-based nano-carriers for highly efficient inhibition of lymphoma cell growth and synchronous reduction of cardiac toxicity
... ment toxicity with Dox-NCs (Figure 5A, left panel). Cardiac toxicities are the most important adverse effect of ...of cardiac cells as revealed by hematoxylin- eosin staining and TUNEL assay (Figure ...
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Ocimum sanctum Linn leaves ameliorates cardiac toxicity by enhancing paraoxonase 1 activity and expression of heart type fatty acid binding protein
... the cardiac function by changing the properties of cardiac cell membrane and these changes may contribute to the cell death that follows coronary artery ...
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Oral treatment with the herbal formula B307 alleviates cardiac toxicity in doxorubicin-treated mice via suppressing oxidative stress, inflammation, and apoptosis
... Methods: Before the animal experiment, we examined relative viabilities of Huh7 cancer cells under treatment with the herbal formula B307. To test whether oral treatment with the herbal formula B307 could alleviate ...
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Prevention of doxorubicin cardiac toxicity in the mouse by N acetylcysteine
... This study was undertaken to investigate the effect of exogenous sulfhydryl compound administration on the toxicity of doxorubicin in mice. Pretreatment of CDF1 mice with a pharmacologic dose (2,000 mg/kg) of ...
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Early Diagnosis of Cardiac Toxicity Related to Antineoplastic Treatment
... therapy-associated cardiac dysfunction remain to be fully elucidated, but generation of reactive oxygen species (ROS) and induc- tion of cardiac myocyte apoptosis are hypothesized to play a central ...the ...
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Role of Ginkgo biloba Extract, Against Isoproterenol Induced Cardiac Toxicity in Rats
... The effect of ISO on heart is mediated through beta receptors. Both adrenoceptors mediate the positive inotropic and chronotropic effects to beta adrenoceptor agonist. It has been reported to cause severe stress in the ...
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PHARMACOLOGICAL EFFICACY OF METHANOLIC EXTRACT OF THE PLANT GINKGO BILOBA, AGAINST ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS
... ABSTRACT: Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was ...
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Acetaminophen Toxicity in Children
... acetaminophen toxicity in the initial differential diagnosis in many illnesses, es- pecially those with unexplained hepatic dysfunc- tion and obtain detailed information regarding acetaminophen ...
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TOXICITY STUDIES OF FULLERENES
... In general, the toxicological data of nanoparticles is insufficient due to the small number of studies, the short exposure period, the different composition of the nanoparticles tested (diameter, length and ...
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Vitamin E Toxicity
... Sokol misunderstands the four vitamin E-induced tox- icities which have been reported in high-risk preterm infants: ( 1 ) Hyperosmolar oral preparations can induce necrotizing enterocoli[r] ...
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Acetaminophen Poisoning and Toxicity
... The half-life of acetaminophen in healthy volunteers given high therapeutic doses is about two hours.5 Patients with hepatotoxicity have increased drug half-life and prognostically, if t[r] ...
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