Cardiomyocyte Apoptosis
Original Article Hypoxia-induced miR-760-3p downregulation promotes cardiomyocyte apoptosis by regulating very-low-density lipoprotein (VLDL) receptor expression
... hypoxia-induced cardiomyocyte injuries, examining their underlying ...and cardiomyocyte apoptosis during hy- ...induced cardiomyocyte apoptosis by increasing caspase-3 activity and ...
10
Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity
... Cardiomyocyte apoptosis is a key event in the process of doxorubicin (DOX)-induced ...DOX-induced cardiomyocyte apoptosis and cardiac dysfunction in vivo, which, however, had almost negligible ...
12
TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways
... progressive cardiomyocyte apoptosis plays a critical role in the LV wall thinning and adverse cardiac remodeling that occur in the setting of sustained ...govern cardiomyocyte cell death in vivo are ...
11
Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1
... of cardiomyocyte homeostasis and cardiac structure, and the prosurvival and antiapoptotic effects of IGF-1 have been ...rat cardiomyocyte apoptosis were ...rat cardiomyocyte was used to ...
18
Original Article Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis
... of apoptosis index. The apoptosis index in the control group was ...the apoptosis index was ...The apoptosis index was increased in the progression of liver ...group. Cardiomyocyte ...
8
Original Article MicroRNA-152-3p negatively regulates ischemia-reperfusion induced cardiomyocyte apoptosis by inhibiting PTEN
... induced cardiomyocyte injury remains ...cell apoptosis in H9c2 ...and apoptosis in H9c2 cells after H/R, while depletion of miR-152-3p in H9c2 cells induced cell ...and apoptosis after I/R in ...
12
MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN
... induced cardiomyocyte injury and the potential ...(ERS)-mediated cardiomyocyte apoptosis, which were attenuated by co-transfection with miR-93 ...I/R-induced cardiomyocyte apoptosis by ...
10
Original Article Trimetazidine protects against hypoxia-reperfusion-induced cardiomyocyte apoptosis by increasing microRNA-21 expression
... Abstract: Myocardial tissue injury caused by ischemia and hypoxia is a major cause of fatal diseases, including coro- nary atherosclerosis resulting from myocardial infarction and stroke. Trimetazidine (TMZ), as an ...
7
Original Article Heart injury alleviated by erythropoietin and the relationship between cardiomyocyte apoptosis and p-Akt protein in rats with myocadial infarction
... cardiomyocytes apoptosis, and the expression of p-Akt protein in myocardial tissues were ...myocardial apoptosis index and p-Akt protein expression in myocardial tissues was ...and cardiomyocyte ...
8
Original Article Effects of tetramethylpyrazine on cardiomyocyte apoptosis after myocardial ischemia reperfusion in rats
... exhibit cardiomyocyte necrosis and apop- tosis, which induce a series of molecular and cellular remodeling processes ...of apoptosis in cardio- vascular diseases has gained recognition ...about ...
8
Influence of hypothermia on right atrial cardiomyocyte apoptosis in patients undergoing aortic valve replacement
... Cardiomyocyte apoptosis has been involved in the patho- physiology of various cardiovascular diseases such as ischemic cardiomyopathy, hibernating myocardium, heart failure, reperfusion injury, and ...
7
ERK-MAPK Signaling Opposes Rho-Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning
... and cardiomyocyte apoptosis (P < ...diomyocyte apoptosis, Caspase-3 activity and myocardial infarction size (P < ...cell apoptosis caused by treatment with PD98059 in ...diomyocyte ...
9
Original Article Targeted regulation of Bcl2 by miR-16 for cardiomyocyte apoptosis after cardiac infarction
... cell apoptosis in I/R model rats compared to Sham group, indicating successful generation of model for further ...for apoptosis after re-oxygenation after hypoxic treatment, accompanied with elevated miR-16 ...
7
PEP 1 CAT protects hypoxia/reoxygenation induced cardiomyocyte apoptosis through multiple sigaling pathways
... Cardiomyocyte apoptosis is an inevitable process dur- ing myocardial ischemia-reperfusion-induced injury ...(H/R)-induced apoptosis model to investigate the mechanisms under- lying the anti-apoptotic ...
9
Original Article Downregulation of miR-34a attenuates myocardial ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis
... rat cardiomyocyte apoptosis were measured as well as miR-34a ...and apoptosis which were accompanied by a significant decrease in caspase-3 ...H/R-induced apoptosis in cardiomyocytes by ...
11
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice
... of apoptosis. Forced cardiac expression of Bnip3 increased cardiomyocyte apoptosis in unstressed mice, causing progressive LV dilation and diminished systolic ...increased apoptosis and ...
10
Effects of Cornus Officinal Is Total Glycoside on Cardiomyocyte Apoptosis and Calcium Overload after Hypoxia/Reoxygenation Injury in Rats
... and cardiomyocyte apopto- sis [3]. Cardiomyocyte apoptosis includes two major pathways, the extrinsic pathway via death receptors, and the intrinsic pathway involving mitochondria [4] ...
10
Original Article Inhibition of microRNA-182 reduces hypoxia/re-oxygenation-induced HL-1 cardiomyocyte apoptosis by targeting the nuclear respiratory factor-1/mitochondrial transcription factor A (NRF-1/mtTFA) pathway
... Abstract: Apoptosis is a component of cardiac remodeling following myocardial ischemia and ...including apoptosis, by regulating gene expression at the post-transcriptional ...of cardiomyocyte ...
9
β1 adrenoceptor stimulation promotes LPS induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation
... apoptosis, caspase-8, 9 and 3 activation and increased cytosolic Ca 2+ concentration in LPS-challenged cardiomyocytes. DOB also up-regulated TNF- α expression, decreased Bcl-2 levels, promoted Bax translocation to ...
15
Original Article Down-regulation of miR-30b reduces cardiomyocyte apoptosis by targeting Bcl-2 in diabetic cardiomyopathy
... cardiomyocytes apoptosis comprises of an extensive network of signaling pathways [18] and few miRs hyperglycemia- induced cardiomyocytes apoptosis have been reported so ...cardiomyocytes apoptosis ...
10