Cardiomyocyte hypertrophy
G Protein-Coupled Estrogen Receptor 1 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy via the Regulation of PI3K-Akt-mTOR Signalling and Autophagy
... on hypertrophy, autophagy serves dual functions, and whether it acts adaptively or maladaptively depends on the degree of autophagy activation and the stage and severity of different diseases ...II-induced ...
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A Xanthine-Derivative K+-Channel Opener Protects against Serotonin-Induced Cardiomyocyte Hypertrophy via the Modulation of Protein Kinases
... cardiac and skeletal muscle is related to different mechanisms of depolarization-contraction coupling [14, 27]. Hescheler et al. (1991) also pointed out that H9c2 cells show morphological characteristics similar to ...
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Cardiac fibroblast–derived microRNA passenger strand enriched exosomes mediate cardiomyocyte hypertrophy
... miRNA targets. miRNAs can regulate dozens to hundreds of targets simultaneously. In our study, we thus performed proteome profil- ing in cardiomyocytes to identify miR-21*–regulated protein can- didates. We demonstrated ...
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S-Nitrosylation Suppresses Stromal Interaction Molecule-1 Activation and Ameliorates Cardiomyocyte Hypertrophy
... The Feng laboratory has recently demonstrated that treatment of HEK293 cells co- expressing YFP-Orai1 and mCherry-STIM1 with the NO donor (GSNO) inhibited STIM1 puncta formation and CRAC current but not in cells ...
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Role of the stress activated protein kinases in endothelin induced cardiomyocyte hypertrophy
... myocyte hypertrophy in vitro (37, ...overload hypertrophy in vivo ...myocyte hypertrophy, including agonists with Gq-coupled receptors, activate the SAPKs and, in some cases, p38 (10, 11, 41, ...
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Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation
... in cardiomyocyte hypertrophy are the calcineurin-NFAT [2,3] and the histone deacetylase (HDAC) [37] pathways, both activated upon an increase in intracellular Ca 2+ signals ...
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Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with gentamicin and 2-APB
... TXA2 is an important inflammatory mediator and could have significant direct actions on the heart during obes- ity and ischemia/reperfusion to potentially promote re- modeling and heart failure. TXA2 levels are elevated ...
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CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
... We imagine 3 explanations for this phenomenon: a CaMKII activates an endogenous kinase in COS cells that induces cytosolic accumulation of HDAC4 independent of CaMKII docking; b there ma[r] ...
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Studies into the Regulation of FTO by Angiotensin II in Cardiomyocyte Hypertrophy
... cardiac hypertrophy. Hypertrophy initially acts as a compensatory mechanism to relieve the stress placed on the heart due to the extra workload that occurs in heart ...decompensatory hypertrophy ...
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Let-7a Is an Antihypertrophic Regulator in the Heart via Targeting Calmodulin
... 1-induced cardiomyocyte hypertrophy by directly targeting genes CaM and Mef2 (myocyte enhancer factor 2); the current study showed that let-7a inhibited AngII-induced cardiac hypertrophy by targeting ...
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PubMedCentral-PMC5453669.pdf
... on cardiomyocyte cross-sectional area ...T3-induced cardiomyocyte hypertrophy (experimental group 3 vs group 2, ...T3-stimulated cardiomyocyte growth (experimental group 6 vs group 3, ...
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Exercise for the heart: signaling pathways
... by cardiomyocyte division and cardiac stem and progenitor cell ...induced cardiomyocyte hypertrophy and proliferation through decreased expression of the transcription factor C/EBPβ and increased ...
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Pressure independent cardiac hypertrophy in mice with cardiomyocyte restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase A
... accompanying cardiomyocyte hypertrophy, and/or (b) abolition of an autoregulatory mechanism by which ANP inhibits its own secretion in an autocrine/paracrine GC-A/cGMP–mediated fashion ...other ...
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Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy
... A hallmark characteristic shared by myocardial hypertrophy and heart failure is reactivation of a fetal gene program, which is a highly sensitive indicator of cardiomyocyte hypertrophy. Therefore, to ...
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IL 33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
... ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels predict outcome in patients with acute ...
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Original Article Telmisartan suppresses cardiomyocyte and alveolar wall hypertrophy by the PPARγ-ERK-NFAT complex by changing the balance of PPARγ and ERK
... Cardiomyocyte hypertrophy is always accom- panied by pathological protein ...of cardiomyocyte pathological protein synthesis, though with opposite ...
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Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation
... cardiac hypertrophy and fibrosis (Figure 1, B and C), an estimation on the potency of endogenous, extracellular cAMP relies on alternative approaches such as interference with ...CM hypertrophy and cardiac ...
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Original Article MicroRNA-152-3p negatively regulates ischemia-reperfusion induced cardiomyocyte apoptosis by inhibiting PTEN
... in cardiomyocyte following I/R injury, while up-regulation of miR-152-3p in cardio- myocyte significantly increased the PI3K/Akt activity both in vivo and in ...that cardiomyocyte protection properties of ...
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Is synovial hypertrophy without Doppler activity sensitive to change? Post hoc analysis from a rheumatoid arthritis ultrasound study
... synovial hypertrophy from baseline ≥ 1 point, coded as a binary variable equal to 1 if a decrease was observed (for a given joint at a given time point) and 0 ...synovial hypertrophy level of each joint as ...
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Original Article Hypoxia-induced miR-760-3p downregulation promotes cardiomyocyte apoptosis by regulating very-low-density lipoprotein (VLDL) receptor expression
... hypoxia-induced cardiomyocyte injuries, examining their underlying ...and cardiomyocyte apoptosis during hy- ...induced cardiomyocyte apoptosis by increasing caspase-3 activity and expression of ...
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