carnitine palmitoyltransferase
Carnitine palmitoyltransferase 1C : from cognition to cancer
... Carnitine palmitoyltransferase 1C was the last of the family of three carnitine long-chain acyltransferases (CPTs) to be identified [1] (the others being CPT1A and CPT1B and CPT2), and in many ...
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Unraveling the Pathway of Lipid Oxidation in the Young Pig: Assessment of Hepatic beta-oxidation and Characterization of Carnitine Palmitoyltransferase I (CPT I)
... adult. Carnitine palmitoyltransferase I remains refractory to the weaning induced decline in activity when rats are maintained on a high fat diet after the suckling ...
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Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase 1 activity and fat oxidation in human skeletal muscle
... via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased malonyl coenzyme A (malonyl-CoA) (a known potent inhibitor of CPT-1) in human muscle during hyperglycemia with ...
8
Detection of Neonatal Carnitine Palmitoyltransferase II Deficiency by Expanded Newborn Screening With Tandem Mass Spectrometry
... ABSTRACT. The introduction of tandem mass spec- trometry to newborn screening has substantially ex- panded our ability to diagnose metabolic diseases in the newborn period. We report the first case of neonatal ...
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Utility of Genetic Testing for Confirmation of Abnormal Newborn Screening in Disorders of Long-Chain Fatty Acids: A Missed Case of Carnitine Palmitoyltransferase 1A (CPT1A) Deficiency
... Carnitine palmitoyltransferase 1A (CPT1A) deficiency is a rare autosomal recessive disorder of long-chain fatty acid ...free carnitine, transaminitis, and elevated coagulation ...
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Molecular basis of hepatic carnitine palmitoyltransferase I deficiency
... is carnitine palmitoyltransferase I (CPT I) deficiency, of which until now no mutations have been reported although the defect is enzymatically well ...the carnitine-dependent transport across the ...
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Effects of three beta adrenergic receptor agonists on growth performance, blood biochemical parameters, fatty acids composition and carnitine palmitoyltransferase I gene expression of rainbow trout, Oncorhynchus mykiss
... of carnitine palmitoyltransferase I in liver and meat and also, fatty acids profile of filet of the rainbow ...of carnitine palmitoyltransferase I in liver was significantly ...
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Infantile form of carnitine palmitoyltransferase II deficiency with hepatomuscular symptoms and sudden death Physiopathological approach to carnitine palmitoyltransferase II deficiencies
... of carnitine palmitoyltransferase II (CPT II) deficiency are characterized only by a muscular symptomatology in young adults although the defect is expressed in extra-muscular tissues as well as in skeletal ...
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Transmembrane domain interactions in carnitine palmitoyltransferase I
... Carnitine palmitoyltransferase 1 enzymes responsible for the regulation of mitochondrial fatty acid oxidation have a central role in many cellular mechanisms such as energy homeostasis (in heart and ...
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Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice
... In this study, the FAT/CD36 and CPTІ protein levels were significantly higher in the EX group than in the CON group (P < 0.001, P < 0.0125). Continuous exercise has been reported to increase the expression of FAT / ...
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Evidence for an Association Between Infant Mortality and a Carnitine Palmitoyltransferase 1A Genetic Variant
... for carnitine palmitoyltrans- ferase deficiency, and the responsibility of the Alaska Division of Public Health re- garding this condition is the same as for all other screened ...
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Carnitine Palmitoyltransferase I and Sudden Unexpected Infant Death in British Columbia First Nations
... of sudden unexpected death in some BC FN individuals and the presence of this variant in the same populations, this study was initiated to determine if bloodspot acylcarnitine pro fi ling[r] ...
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Stabilization of the thermolabile variant S113L of carnitine palmitoyltransferase II
... was applied for the energy minimization steps, whereas Particle- Mesh-Ewald molecular dynamics (MD) was used for the MD simulation. Particle-Mesh-Ewald method was used to treat elec- trostatic interactions, and a cut-off ...
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Investigation and characterisation of transmembrane domain interactions in Carnitine Palmitoyltransferase 1 Isoforms
... Chapter 6: Measuring CPT1B TM Domain Interactions Using In Vitro Experiments spectroscopy TOCSY and nuclear Overhauser effect spectroscopy NOESY can however be used to assign small prote[r] ...
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Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C
... Fatty acid oxidation is essential for oocyte and early embryonic development [9]. Recent work suggests that fatty acid synthesis is critical for pluripotency [14]. Unfortunately, the study of fatty acid oxidation during ...
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Relationship between central and peripheral fatty acids in humans
... ALA: Alpha-linolenic acid; AA: Arachidonic acid; BBB: Blood brain barrier; CPT1: Carnitine palmitoyltransferase-1; CSF: Cerbrospinal fluid; cAMP/ PKA: Cyclic adenosine monophosphate/prot[r] ...
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Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice
... CPT1A: Carnitine palmitoyltransferase 1A; FAS: Fatty acid synthase; FAT/CD36: Fatty acid translocase/cluster of differentiation 36; FATP5: Fatty acid transporter member 5; H&E: Hematoxylin and eosin; ...
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Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders
... ACAD: acyl-CoA dehydrogenase (in the context of this paper referring to SCAD, MCAD, LCAD, and VLCAD together); CPT2: carnitine palmitoyltransferase 2; CROT: crotonase; ETF: electron tran[r] ...
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Leptin produced by obesity altered adipose stem cells promotes metastasis but not tumorigenesis of triple negative breast cancer in orthotopic xenograft and patient derived xenograft models
... PDF 361 kb Abbreviations ASCs: Adipose stem cells; BMI: Body mass index; CCM: Complete culture media; CM: Conditioned media; CPT1: Carnitine palmitoyltransferase 1; CSCs: Cancer stem cel[r] ...
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A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes
... of carnitine palmitoyltransferase 1B (CPT-1B) – the rate-limiting enzyme in the soleus muscle, alongside other key fat oxidation genes: peroxisome proliferator- activated receptors 1α and δ, uncoupling ...
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