casein kinase
Casein kinase 1α–dependent feedback loop controls autophagy in RAS driven cancers
... that casein kinase 1α (CK1α), a ubiquitously expressed serine/threonine kinase, is a key negative regulator of oncogenic RAS–induced ...a kinase feedback loop that influences RAS-dependent ...
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Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival
... of casein kinase (CK) 2 a, a phophorylated Akt and urokinase type plasminogen activator (uPA), resulting in p27 induction, cell cycle arrest at G1 phase and cell growth suppression in human urothelial ...
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Spermiogenesis Initiation in Caenorhabditis elegans Involves a Casein Kinase 1 Encoded by the spe-6 Gene
... Figure 4.—A model structure for SPE-6. An alignment of the predicted SPE-6 polypeptide se- quence mapped onto the crystal structure of the mammalian casein kinase 1 ␦ catalytic region (res- idues 1–317 PDB ...
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Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila
... ABSTRACT We are using a candidate gene approach to identify genes contributing to cancer through somatic mutation. Somatic mutations were found in breast cancer samples in the human casein kinase I epsilon ...
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Original Article Aberrant expression of casein kinase 1δ (CK1δ) in cervical squamous cell carcinoma
... The Wnt/β-catenin signaling pathway plays critical roles in tumorigenesis and metasta- sis in different types of can- cer [15, 16]. Stabilization of β-catenin upregulates down- stream target genes [17, 18]. Degradation ...
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Glc7–Reg1 Phosphatase Signals to Yck1,2 Casein Kinase 1 to Regulate Transport Activity and Glucose-Induced Inactivation of Saccharomyces Maltose Permease
... downstream kinase activity of pathway ...Yck1,2 kinase activity stimulates the internalization of several Saccharomyces plasma membrane proteins, including the Ste2 a-factor receptor (H icke 1999), the Ste3 ...
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Erythrocytic Casein Kinase II Regulates Cytoadherence of Plasmodium falciparum-infected Red Blood Cells
... Plasmodium falciparum malaria is a major human health scourge and a key cause of mortality. Its pathogenicity partly results from the phenomenon of “cytoadherence” mediated by the PfEMP1 (Plasmodium falciparum ...
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Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly.
... and kinase inhibitor experiments, the phosphorylation levels of both HDAgs were diminished by the inhibitor of casein kinase II ...protein kinase C (PKC) inhibitor, suggesting different ...
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Regulation of the Drosophila melanogaster Protein, Enhancer of Rudimentary, by Casein Kinase II
... The Drosophila melanogaster gene enhancer of rudimentary , e(r), encodes a conserved protein, ER. Most ER homologs share two casein kinase II (CKII) target sites. In D. melanogaster , these sites are T18 ...
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Negative Regulation of Haa1 by Casein Kinase I protein Hrr25 in Saccharomyces cerevisiae
... of casein kinase I in the budding yeast, has been reported to be an essential protein in the BY4741 background, and the essential function is linked to maturation of the pre-40S ribosomal subunit ...
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Rotavirus NSP1 Requires Casein Kinase II Mediated Phosphorylation for Hijacking of Cullin RING Ligases
... ABSTRACT The rotavirus nonstructural protein NSP1 repurposes cullin-RING E3 ubiqui- tin ligases (CRLs) to antagonize innate immune responses. By functioning as substrate adaptors of hijacked CRLs, NSP1 causes ...
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Activation of skeletal muscle casein kinase II by insulin is not diminished in subjects with insulin resistance
... To identify the putative postreceptor lesion responsible for insulin resistance in Pima Indians, we investigated the influence of insulin on the activity of casein kinase II CKII in skel[r] ...
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Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response
... CK2 inhibits RIG-I signaling and suppresses RIG-I-medi- ated antiviral response. The protein kinase CK2 is a universal kinase that phosphorylates proteins at Ser/Thr. Bioinformation analysis reveals that ...
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Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity
... residue is an important determinant of Hsp90 ATPase activity and drug sensitivity; T22 phosphorylation affects Hsp90 chaperone function and alters its sensitivity to Hsp90 inhibitors.. F[r] ...
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Casein kinase 1α: biological mechanisms and theranostic potential
... Pyrvinium is an FDA-approved antihelminthic drug that has now been replaced by a more effective, broad-spectrum alternative, although it is still available under the Parke-Davis label in Europe and under the name pamoxan ...
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Phosphorylation of varicella-zoster virus glycoprotein gpI by mammalian casein kinase II and casein kinase I.
... Lanes: 1, 4, and 7, immunoprecipitates added to protein kinase assays with no exogenous source of phosphotransferase activity; 2, 5, and 8, immunoprecipitates added to kinase assays with[r] ...
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Casein Kinase 2-Mediated Phosphorylation of Respiratory Syncytial Virus Phosphoprotein P Is Essential for the Transcription Elongation Activity of the Viral Polymerase; Phosphorylation by Casein Kinase 1 Occurs Mainly at Ser215 and Is without Effect
... In our second approach, we investigated the phosphoryla- tion status of P following abrogation of CK2. Although CK2- mediated phosphorylation of RSV P can be inhibited by chem- ical inhibitors such as heparin in vitro ...
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Functional implications of mutations within polyomavirus large T antigen Rb-binding domain: effects on pRb and p107 binding in vitro and immortalization activity in vivo.
... the casein kinase II consensus phosphorylation region flanking the Rb-binding domain, or the deletion of amino acids 256 to 272, increased the immortalizing activity of the mutant polyomavirus large T ...
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Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction
... that Casein Kinase I phosphorylates Mdm2 at multiple sites to trigger Mdm2 interaction with, and subsequent ubiquitination and destruction by the SCF β-TRCP E3 ubiquitin ...
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Differential Roles of the Glycogen-Binding Domains of β Subunits in Regulation of the Snf1 Kinase Complex
... protein kinase family, including the Snf1 kinase of Saccharomyces cerevisiae, are activated under conditions of nutrient ...protein kinase consisting of Snf1 ( ␣ ), Snf4 ( ␥ ), and one of three ...
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