Caspase-3
Caspase 3 and caspase 8 expression in breast cancer: caspase 3 is associated with survival
... and caspase protein ...and caspase protein expression was combined to assess asso- ciations with breast cancer-specific ...high caspase-3/high calpain-2 and high caspase-3/low ...
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Activation of caspase 3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions
... of caspase-3–mediated degradation of acto- myosin to total protein degradation in muscle, we pre- pared a cell-free extract from rabbit muscle that contains the components of the Ub-P’some system as ...
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Serum Caspase 3 and Caspase 7 as Predictive Factors of Response in Locally Advanced and Metastatic Breast Carcinoma
... evaluating Caspase-3, 7 levels in serum of patients with locally advanced and metastatic breast cancer and establishing the relation between Casepase level and response to ...with Caspase-3, 7 ...
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Nitric oxide production is associated to increased lipoperoxidation and active caspase 3 in demyelinated brain regions of the taiep rat
... cleaved caspase-3 immunoreactivity was analyzed by an immunohistochemical ...Technology, 3 Trask Lane, Danvers, MA 01923) and then with the secondary antibody bioti- nylated anti-rabbit IgG (H + L), ...
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Herpes Simplex Virus 1 Blocks Caspase-3-Independent and Caspase-Dependent Pathways to Cell Death
... that caspase inhibitors do not block DNA fragmentation induced by infection with the HSV-1 d120 ...a caspase-3-independent pathway inasmuch as caspase 3 was not activated and DNA ...
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Original Article Poly (ADP-ribose) synthetase inhibitor has a heart protective effect in a rat model of experimental sepsis
... group, 3-AB pretreatment group and 3-AB treatment group, 15 rats per ...and caspase 3 activity in the myocardium tissue, levels of serum creatine kinase muscle brain (CK-MB) fraction and tro- ...
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Heliothis zea Nudivirus 1 Gene hhi1 Induces Apoptosis Which Is Blocked by the Hz-iap2 Gene and a Noncoding Gene, pag1
... siently transfected Sf-21 cells. It has been reported that some virus-encoded transcription factors, such as baculovirus IE1 and human immunodeficiency virus Tat, are proapoptotic, whereas some DNA viruses trigger ...
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Caspase dependent secondary lens fiber cell disintegration inα A /αB crystallin double knockout mice
... of caspase 3 activity was suggested from in vitro and tissue culture ...anti-active caspase 3 antibodies, in which the brightest signal for the active form of caspase 3 in the ...
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Molar tooth development in caspase 3 deficient mice
... mutants. Caspase-3 -/- / 129X1/SvJ first molar tooth germs did not show any obvious differences compared to caspase-3+/+/129X1/SvJ in frontal ...
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Cytotoxic effects of Euterpe oleracea Mart in malignant cell lines
... of Caspase- Glo® 3/7 luminescent assays were consistent with these re- sults, in that no differences were seen between the caspase 3 and caspase 7 activity of control and treated ...
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Epstein Barr viral microRNAs target caspase 3
... apoptosis, Caspase 3 (CASP3), was proposed as a target of select EBV ...CASP3 3 ′ -UTR, we identified 12 EBV miRNAs that have one or more seed binding sites in the CASP3 3 ′ ...
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Pentoxifylline suppressed LPS induced inflammatory and apoptotic signaling in neuronal cells
... agent in a variety of cells, has been used in this study to confirm this property in neuronal cells. To determine the effect of PTX on LPS-induced cytokine expression, western blot assay of TNF-α expression, as an ...
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Original Article Expression of caspase-3 gene in gastric adenocarcinoma cell line SGC-7901 via Ad-FasL
... in caspase-3 expression was noted in gastric carcinoma cells transfected with the FasL gene, indicating that FasL gene transfection induces apoptosis and that apoptosis signal transduction pro- duced after ...
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Building Positive Future Orientations: The Role of Natural Mentors in the Lives of African American Girls
... associated X protein) and Bak (Bcl-2 homologous antagonist/killer protein), also reside in the mitochondrial membrane (Figure 4). Based on their resemblance to bacterial pore forming channel proteins, Bax and Bak are ...
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Evaluation of the Protective Effects of Ginger Extract on Cisplatin Induced Cardiotoxicity in Male Albino Rats
... Purpose: This study was aimed to evaluate the protective effect of ginger extract against cisplatin-induced cardiotoxicity in male albino rats. Methods: The animals were divided into seven groups of 10 animals in each ...
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Original Article Toll-like receptors promote apoptosis of retinal ganglion cells in diabetic retinopathy via regulating Caspase-3 and Bcl-xL
... Since TLRs might mediate cell apoptosis in DR, we further analyzed its regulation on two apop- tosis-related factors, Caspase-3 and Bcl-xL. Caspase-3 was significantly up-regulated in RGC (WT) ...
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Sendai Virus Infection Induces Apoptosis through Activation of Caspase-8 (FLICE) and Caspase-3 (CPP32)
... Detection of activation of individual caspases. To further define the relevant steps employed in the SV-triggered apo- ptotic signal transduction pathway, we investigated the activa- tion of individual caspases during SV ...
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Activation of Caspase-2 in Apoptosis
... of Caspase-2 Occurs Later than the Activation of Caspase-3-like Proteases when Cells Undergo Apoptosis—To determine possible interactions between caspase-2 and other family members, we ...
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MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7
... The cells were lysed with RIPA buffer (25mM Tris-HCl (pH 7.6), 150mM NaCl, 1% NP-40, 1% sodium deoxycholate, 0.1% SDS) supplemented with Protease/Phosphatase inhibitor Cocktail (Cell Signaling Technology), and separated ...
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Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells
... Apoptosis (programmed cell death) is a critical barrier to tumorigenesis [10]. During apoptosis, activated caspases are the main executor enzymes that selectively cleave proteins. They are a multifunctional, highly ...
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