caspase inhibitors
Reactive-Site Cleavage Residues Confer Target Specificity to Baculovirus P49, a Dimeric Member of the P35 Family of Caspase Inhibitors
... P35-related caspase inhibitors, P49 is unique in its capacity to inactivate both initiator and effector caspases in ...anti-initiator caspase activity, P49 functions as an effector caspase ...
11
Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis
... (a caspase-9 selective inhibitor) and RBC1023 (a caspase-3 selective inhibitor) with no cytotoxicity alone demonstrated ...compounds. Caspase inhibitors could have potential application in ...
18
Baculovirus Caspase Inhibitors P49 and P35 Block Virus-Induced Apoptosis Downstream of Effector Caspase DrICE Activation in Drosophila melanogaster Cells
... both caspase inhibitors were produced in excess from the same ie-1 promoter in cells containing acti- vated endogenous caspases due to ...the caspase cleavage products of P49 or P35 provided a ...
12
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
... precede caspase-dependent apoptotic cell death and a wealth of data has linked TNF bioactivity to caspase activation and apoptosis in various cell types (reviewed in ...the caspase-9/-3 cascade in C6 ...
19
Caspase 3-Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis
... and caspase 3 inhibitors re- duced the WNV-mediated death of primary neurons, which is consistent with studies showing that caspase inhibitors reduced apoptosis after transgenic expression of ...
10
Heliothis zea Nudivirus 1 Gene hhi1 Induces Apoptosis Which Is Blocked by the Hz-iap2 Gene and a Noncoding Gene, pag1
... insect caspase-3-like protein. (A) Assay of the caspase activity induced by hhi1 ...ApoAlert caspase assay kit (Clontech) was used to measure caspase activities in Sf-21 cells transfected with ...
11
Preliminary safety evaluation of novel small molecule inhibitors of caspase 3
... Several reports demonstrated that inhibition of caspases protect the liver from apoptosis-associated liver injury in preclinical models. Protypical caspase inhibitors such as ZVAD-FMK were efficacious in ...
5
Investigation of Orally Administered Small Molecule Inhibitors of Caspase-3 in Murine Models of Apoptosis
... irreversible caspase inhibitors are effective at protecting against endotoxic shock and lipopolysaccharide (LPS)/D- galatosamine liver injury ...irreversible caspase inhibitors in preclinical ...
7
VX 166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
... of caspase inhibitors in ...of caspase inhibitors in sepsis ...describes caspase-1-independent release of IL-1β from neutrophils ...by caspase inhibition (data not ...
11
Programmed cell death in plants and caspase-like activities
... effector caspase much more efficiently than by either the inflammatory caspase-1 (Gu et ...initiator caspase-8 (Nicholson et ...specific inhibitors of PARP cleavage and as affinity ligands for ...
179
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice
... sulfone caspase inhibitors are non toxic to human neurons and neuroprotective against serum deprivation or APP over- ...NWL inhibitors prevent serum-deprivation- or APP WT -expression induced ...
19
New Developments in Drug Therapy and Research of Cerebral Vasospasm
... Zhang, “Caspase Inhibitors Prevent Endothelial Apoptosis and Cerebral Vasospasm in Dog Model of Experimental Subarachnoid Hemorrhage,” Journal of Cerebral Blood Flow & Metabolism, Vol.. [r] ...
22
Costunolide induces mitochondria mediated apoptosis in human gastric adenocarcinoma BGC 823 cells
... The gastric cancer BGC-823 cells (2 × 10 6 cells in 0.2 mL PBS) was injected subcutaneously into the right flank of athymic BALB/c nude mice. After 12 days, 16 mice were randomly divided into 4 groups: blank (saline), ...
10
FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia
... cleaved Caspase-3 (CS-9661), Caspase-9 (CS-9508), cleaved Caspase-9 (CS-9509), phospho-Y694-STAT5 (CS-9359), Erk (CS-9102), phospho-T202/Y204-Erk (CS-9106), non-phospho- T46–4EBP1 (CS-4923), ...
17
Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways
... 1 mM PMSF, and PI cocktail on ice for 30 min. The lysates were cleared by centrifugation at 13,000 rpm for 20 min at 4°C. The supernatant was stored at −70°C until use. The protein concentration was quantified using a ...
12
INDUCTION OF APOPTOSIS BY CASPASES IN THE LEAVES OF SANSEVIERIA ROXBURGHIANA SCHULT AND SCHULT F
... www.wjpr.net Vol 4, Issue 2, 2015. 1475 The anticancer activity of methanol leaf extract of S. roxburghiana is already established. [23] Therefore elevation in activities of caspase-3 and caspase-9 (Fig 1) ...
6
Vol 68, No 1 (2016)
... Numerous findings have demonstrated that en- dothelial dysfunction is a systemic process that is the first step in the pathogenesis of atherosclerosis and atherosclerotic plaque progression (Hattori et al., 2006). ...
10
Rudy, Anita (2007): Unusual apoptotic signaling pathways in cancer cells induced by cephalostatin. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Inhibitor of apoptosis proteins (IAPs) are shown to be expressed to a higher extent in cancer than in normal tissue and are connected to chemoresistance. Smac/DIABLO binds to various IAPs thus neutralizing their ...
108
Elevated expression of caspase 3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium
... cleaved caspase-3 expression. Additionally, our finding that the mRNAs of caspase-3, xIAP and survivin were generally higher in active RA compared with inactive RA synovial tissue is consistent with the ...
11
Pogrebniak, Alexei (2003): Protektive in vitro Wirkung mitochondrialer Entkoppler auf die Apoptose in Leukämiezellinien. Dissertation, LMU München: Medizinische Fakultät
... DNA-Fragmentation, Caspase-3- abhängige proteolytische Spaltung von PARP, Aktivität von Caspase-3, sowie die Bestimmung des intrazellulären NAD + -, NADH-, NADPH- und ATP-Gehaltes erfolgt zu einem späteren ...
79