Cathepsin B (CTSB)
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
... “cathepsin B hypoth- esis” is based on the following observations: (a) CTSB was shown to activate trypsinogen in vitro (9); (b) dur- ing the initial phase of acute pancreatitis in several ...
10
Original Article Expression of cathepsin B in human hepatocellular carcinoma and its prognostic significance
... [9-11]. CTSB was observed to activate the phosphoinositide 3-kinase (PI3K)/ Akt signaling pathway to promote HCC prolifera- tion ...of cathepsin B has been observed in malignant tumors, and spe- ...
8
Elucidating the role of cathepsin B in the lifecycle of influenza A virus
... protease cathepsin B (CTSB), though the mechanism behind this dependency was not ...of CTSB by examining different stages in the viral lifecycle for defects using CTSB-deficient ...
94
Interaction of the Hepatitis B Spliced Protein with Cathepsin B Promotes Hepatoma Cell Migration and Invasion
... Hepatitis B spliced protein (HBSP) is involved in the pathogenicity and/or persistence of hepatitis B virus ...with cathepsin B ...down CTSB also reduced cell migration and ...or ...
9
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
... lysosomal, cathepsin B–dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains ...if Ctsb inactivation attenuates liver ...
9
Cathepsin B trafficking in thyroid carcinoma cells
... Cathepsin B cDNA was derived from FRTL-5 cells, a Fisher rat thyroid cell line, as described previously ...the cathepsin B ...of cathepsin B into the pEGFP-N1 vector after fusion ...
16
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis
... [24]. Thus, cathepsin B proteases clearly play an import- ant role in the biology of trematode parasites. Cysteine proteases were abundant genes in C. sinensis genome and transcriptome. As the main ...
13
Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat
... Cathepsin B activity was selectively elevated early in the course of ...a cathepsin B inhibitor, and indomethacin, a prostaglandin synthesis inhibitor, prevented muscle atrophy and impaired ...
5
Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid- derived suppressor cells
... of cathepsin B and cathepsin D was required to significantly decrease LCL521-induced cell ...activate cathepsin B and cathepsin D, resulting in interrupted autophagy and ER ...
19
Cathepsin B: a potential prognostic marker for inflammatory breast cancer
... cells, CTSB is shuttled to the plasma membrane where it can activate receptor-bound pro-urokinase-type plasminogen activa- tor ...[10]. CTSB is associated with cell surface caveo- lae, specialized membrane ...
8
Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity
... Figure 3: Nitroxoline impairs invasion of transformed and tumor cells. (A) Invasion of cells was assessed in real time using the xCELLigence System [30]. siRNA-mediated silencing was performed 6h before the start of ...
16
Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
... Convergence and extension are altered in split top mutants split top mutant embryos displayed altered overall morphology suggestive of defects in convergence and extension. Therefore, convergence and extension were ...
13
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
... either cathepsin B or caspases attenuates GCDC- induced apoptosis; (b) inhibition of caspases prevents the increase in cathepsin B activity, but cathepsin B inhibition ...
10
Assessment of the Roles of Cathepsins B, H and L in the Progression of Colorectal Cancer
... of cathepsin H in tu- mor development and progression and its varying be- havior as cancer proceeds, in comparison to cathepsins B and ...L. Cathepsin B expression levels doubled in all tu- ...
7
Host Cell Cathepsins Potentiate Moloney Murine Leukemia Virus Infection
... of cathepsin B cleavage, aliquots of pelleted virus were incubated at 37°C for 1 h in acetate buffer (pH ...of cathepsin B ...sin B, and in some cases, reaction mixtures were incubated ...
9
High pressure effects on the activities of cathepsins B and D of mackerel and horse mackerel muscle
... cathepsins B and D in the muscles of mack- erel (Scomber scombrus) and horse mackerel (Trachurus ...the cathepsin B activity decrease reached 40% at 450 MPa while in horse mackerel, low and ...
6
Virtual screening and molecular docking of Anti-Antileishmanial for selected pharmacophore for visceral Leishmaniasis
... Leishmaniasis, Cathepsin like cysteine protease is an important target protein for the identification of novel lead compound of ...Leishmaniasis. Cathepsin like cysteine protease representing a major ...
6
The mRNA expression and enzymatic activity of three enzymes during embryonic development of the hard tick Haemaphysalis longicornis
... In arthropods, the interaction effect between acid phos- phatase and other hydrolases on Vn degradation dur- ing embryogenesis has been mentioned. In D. maxima, R. microplus and R. prolixus, acid phosphatase has been ...
8
Differential sialotranscriptomes of unfed and fed Rhipicephalus haemaphysaloides, with particular regard to differentially expressed genes of cysteine proteases
... Subsequently, cathepsin B (CATB) and cathepsin L (CATL) participate in the secondary digestion, to generate smaller ...and cathepsin C (CATC), small fragments are degraded into ...
13
Microglial-neuronal interactions
... 5.5.4 Neither mitochondrial depolarisation or nitric oxide production are involved in conditioned medium or cathepsin B induced HT22 cell death. (A)[r] ...
266