Cathepsin Y
Altered distribution of lysosomal cathepsin D in ischemic myocardium
... observed in control myocytes was replaced by bright fluorescent patches composed of large granules. Many of these structures displayed prominent halos of diffuse fluorescent staining in the neighboring myocytic ...
12
Docking of Cathepsin D with New Compounds
... 2) Molecular Docking: AutoDock Tools 4.0 was used to perform docking. All the above processed ligands and protein structure were used for docking. Grid parameter files were generated in Auto grid. Grid dimensions on X, ...
5
IMMUNOHISTOCHEMICAL EXPRESSION OF CATHEPSIN K IN EPIDERMAL TUMORS.
... with Cathepsin K mouse monoclonal antibody (Santa Cruz Biotechnology; Santa Cruz, CA) which can detect cathepsin K of human origin with the following steps according to Hsu et al [13] : ...
11
Cathepsin B trafficking in thyroid carcinoma cells
... of cathepsin B to the apical plasma membrane domain of normal thyroid epithelial cells is a prerequisite for its TSH-stimulated secretion into the follicle lumen in order to maintain thyroid homeostasis ...
16
The lysosomal protein cathepsin L is a progranulin protease
... Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown ...
9
Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes
... Notably, we detected two easily separable bands for CtsW on Western blots; the top band could sometimes be observed as a doublet. In contrast, only a single band could be detected for the catalytically inactive mutant. ...
12
Increased Serum Cathepsin K in Patients with Coronary Artery Disease
... the patients with UAP and AMI had higher levels of hs- CRP than did the SAP subjects. We detected higher cathep- sin K levels in patients with UAP and AMI compared to those with SAP. Moreover, our data revealed a ...
8
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
... Biosciences), cathepsin D (goat polyclonal, 1:1000; R&D Systems, recognizing pro-cathepsin D (52 kDa), an active intermediate (48 kDa) and the heavy chain of active cathepsin D (34 kDa)), ...
18
Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid- derived suppressor cells
... of cathepsin B and cathepsin D was required to significantly decrease LCL521-induced cell ...activate cathepsin B and cathepsin D, resulting in interrupted autophagy and ER stress that ...
19
Extracellular cathepsin L stimulates axonal growth in neurons
... while cathepsin B-null mice did not have an obvious phenotype ...of cathepsin L and cathepsin B clearly demonstrated a brain-specific phenotype, such as neuronal death in the cerebral cortex and ...
5
Cathepsin S activity regulates antigen presentation and immunity
... K). Cathepsin K is not found in APCs, but cathep- sin L is found in some murine B cells ...Can cathepsin L compensate for the ab- sence of cathepsin S in degrading Ii from ab Ii complexes, ren- ...
14
Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity
... cells was observed on MSG epithelial cells from SS model mice, and MHC class II molecule can be stably induced by IFN- γ stimulation on MSG cells from syn- geneic control mice. Moreover, autoantigen-stimulated ...
10
Silver and Gold Nanoparticles Alter Cathepsin Activity In vitro
... purified cathepsin B or L, which were then assayed for ...purified cathepsin B enzyme with the 10-nm Ag-NPs at 10 μg/ml and even greater at 50 μg/ml, regardless of the presence or absence of the PS coating ...
7
Influence of a prudent diet on circulating cathepsin S in humans
... cardiovascular risk factors, such as elevated triglycerides [17] and LDL-C [13]. Subjects on ND for 6 weeks mark- edly improved their cardiovascular risk profile, including lowering of LDL-C, insulin resistance, and ...
5
Cellular biology of antigen processing: The role of cathepsin E
... Having established that the endocytic antigen processing m achinery of the hum an peripheral blood derived DC is altered by maturation with LPS, the subcellular localisation of CE was then examined in these cells. Figure ...
252
Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis
... In cathepsin S inhibitor-treated mice only indi- vidual epithelioid cells without well-formed granulomas were observed (Figure 5G) and epithelioid cells were present in 30% of mouse ...night. Cathepsin S is ...
10
Cathepsin L increases invasion and migration of B16 melanoma
... extracellular cathepsin L since extracellular matrix degradation by cathepsin L is known to ...to cathepsin involvement in tumor cell migration comes from a study of cathepsin B knockdown in ...
9
Neurotrophic Factors Regulate Cathepsin S in Macrophages and Microglia: A Role in the Degradation of Myelin Basic Protein and Amyloid β Peptide
... compared to control cells (Fig. 5A), which is consistent with the relative decrease in cathepsin S mRNA after 48 hr (data not shown). Therefore, cellular cathepsin S activity in macropha[r] ...
10
The Action of Cathepsin D in Human Articular Cartilage on Proteoglycans
... human cathepsin D-type enzyme, as well as a highly purified cathepsin D from bovine uterus degraded proteoglycan subunit (PGS) maximally at pH ...human cathepsin extract was not affected by reagents ...
11
Exploring Leishmania infantum cathepsin as a new molecular marker for phylogenetic relationships and visceral leishmaniasis diagnosis
... Results: The cathepsin L-like gene did not show any intraspecies variability among the isolates analyzed. The pair of primers proposed amplified the target deoxyribonucleic acid (DNA) of L. infantum isolates and ...
9