Cation channel
The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies
... MHITC reportedly activated both mTRPA1 and hTRPA1, suggesting that these biological activities of isothiocyanates are due to TRPA1 activation [112]. TRPA1 is a cation channel and is co-expressed with the ...
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Endothelial cation channel PIEZO1 controls blood pressure by mediating flow induced ATP release
... mechanosensitive cation channel PIEZO1 is required for flow-induced ATP release and subsequent P2Y 2 /G q /G 11 –mediated activation of downstream signaling that results in phosphorylation and activation of ...
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Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
... -permeable cation channel expressed in airway epithelial cells. This channel plays a role in the transduction of physical and chemical stimuli into Ca 2+ signals that regulate ciliary beat frequency ...
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<p>Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling</p>
... potential cation channel protein 6 (TRPC6) is colocalized in the kidney podocyte glomerular slit diaphragm with the protein, ...TRPC6 channel is induced by phospholipase C (PLC) stimulation and its ...
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Stretch activated cation channel from larval bullfrog skin
... The selectivity properties of the larval SAC are similar to that of the non-selective cation channel that Hillyard et al. (Hillyard et al., 1982) characterized in the apical membrane of isolated larval skin ...
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Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
... Here we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function. Immunofluorescence demonstrated TRPV4 expression in ...
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A Calcium Activated Nonspecific Cation Channel from Olfactory Receptor Neurones of the Silkmoth Antheraea Polyphemus
... In another study we showed that the outer dendritic plasma membrane of silkmoth ORNs in situ seems to be exclusively equipped with a specific sex-pheromonesensitive ion channel the ACi c[r] ...
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Structure and pharmacological properties of a molluscan glutamate-gated cation channel and its likely role in feeding behavior.
... Hybridization-positive neurons were detected in all of the nine central ganglia (i.e., right and left cerebral ganglia, right and left parietal ganglia, right and left pedal [r] ...
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Activation by Membrane Stretch and Depolarization of an Epithelial Monovalent Cation Channel from Teleost Intestine
... In excised, inside-out membrane patches, channel activity could be enhanced in the absence of membrane tension by strong depolarization of the membrane potential Vm to between OmV and +9[r] ...
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The Promotion of Gonadal Cell Divisions by the Caenorhabditis elegans TRPM Cation Channel GON-2 Is Antagonized by GEM-4 Copine
... the channel is consti- require the activity of GON-2, a predicted cation chan- tutively active and may be regulated at the level of trans- nel of the TRPM (M for melastatin) subfamily of TRP location to the ...
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An evolutionarily unique heterodimeric voltage gated cation channel found in aphids
... performed initially with degenerate primers (Supplementary Table 3) complementary to the predicted channel sequence of A. pisum and subsequently with specific primers (Supplementary Table 3) and PFU enzyme ...
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Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma
... CD4 + T cells are thought to play a prominent role in the development of allergic asthma, thus targeting them is considered to be a viable means to combat the disease. Re- cently it has been shown that human and mouse ...
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TRPM8, A Calcium Permeable Non-selective Cation Channel
... research for pharmacological agents sensitive to trPM8 has been extremely active since 2002 following discovery of the channel. A number of natural and synthetic compounds have been identified as agonists or ...
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Mucolipin 2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses
... The TRPML family contains three proteins, MCOLN1, MCOLN2, and MCOLN3. These TRPML family channels produce inwardly rectifying cation currents (8–10). Loss-of- function mutations in mucolipin-1 cause the human ...
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An evolutionarily unique heterodimeric voltage gated cation channel found in aphids
... sion 2 assembly for clone G006. The two genes are again (as with the A. pisum channel) orientated in opposite directions on the genomic scaffold (Fig. 3), but this time in immediate (1 Kb) prox- imity to each ...
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How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways
... potential cation channel, subfamily A, member 1 (TRPA1) receptors in airway sensory neurons, resulting in neurogenic inflammation and respiratory ...
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New differentially expressed genes and differential DNA methylation underlying refractory epilepsy
... potential cation channel, subfamily C, member 4 generalized epilepsy with photosensitivity CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit IGE / CAE / generalized epilepsy ...
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Design and Implementation of New Data Validation Service (NDVS) Using Semantic Web Technologies in Web Applications
... Because of the possibility of bypassing input validation either on client-side or server-side, data integrity of web application can be violated even though the communi- cation channel between the server ...
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In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model
... potential cation channel, member A1 (TRPA1) antagonist identified during a focused drug discovery ...TRPA1 channel heterologously expressed in human embryonic kidney ...TRPA1 channel in ...
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Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina
... endogenous channel β -subunit, cGMP phosphodiesterase α -subunit, peripherin2/RDS and guanylate cyclase I were present at WT levels and were properly localized within the ...cGMP-gated cation channel ...
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