CB1 receptor
Original Article Effects of propofol on CB1 receptor expression in spinal cord of rats with intrathecal morphine-induced pruritus
... of CB1 receptors expression in spinal cord and ACC were produced at the same time, so there was no judgment of propofol firstly exciting CB1 receptors in spinal cord or in ...stimulate CB1 ...
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
... The second class of compounds prepared were based on the 4,5-diaryltriazole ring system. They were prepared to investigate the effects of the orientation of triazole system on CB1 receptor affinity. ...
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Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... tissue, and low expression of iNOS is associated with reduced risk of death (13). Furthermore, iNOS inhibi- tors have antifibrotic activity in animal models of PF (14, 15), making iNOS a viable therapeutic target for PF. ...
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Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice
... these data resemble to some extent our previous results showing a suppression of cross-sensitisation to methamphetamine with the CB 1 receptor agonist ACPA. These discrepancies in results on the involve- ment the ...
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The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice
... cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in ...1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory ...
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Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
... A series of N-benzhydryl-3-benzyloxyazetidines were synthesized from commercially available 2-benzyloxy glycerol and a series of substituted benzhydryl amines. The N-benzhydryl-3-benzyloxyazetidines were obtained in good ...
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Hepatic CB1 receptor is required for development of diet induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
... cannabinoid receptor CB 1 (CB1 –/– ) do not display these changes in association with diet-induced ...to CB1 –/– mice, had less steatosis, hyperglycemia, dyslipidemia, and insulin and leptin ...
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High Resolution X-ray Diffraction Analysis of CB1 Receptor Antagonists as a Means to Explore Binding Affinity
... receptors have an effect on food intake when in the CNS, they also play a role in the hormonal signaling to the brain that food is required, causing the experience of hunger. The experience of hunger is complex and ...
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Adolescent Exposure of JWH 018 “Spice” Produces Subtle Effects on Learning and Memory Performance in Adulthood
... cannabinoid CB1 receptor agonist during adolescence is capable of producing a variety of subtle changes affecting spatial learning and memory performance in adulthood, well after the drug exposure ...
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Pharmacodynamics of cannabinoids
... cannabinoid receptor ligands were of high signi ...“agonistic” receptor activity were discovered: 2AG (arachidonoyl glycerin ether) [5], NADA (N-arachidonoyl dopamine) ...called CB1 receptors [7]. ...
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Agonists of CB1 and NMDA receptors decrease the toxic effect of organophosphorus compound paraoxon on PC12 cells
... of CB1 and NMDA receptors agonists ACEA and NMDA, respectively, protected PC12 cells from POX‑induced ...that CB1 receptor antagonist AM251 suppressed the protec- tive ACEA effect against paraoxon ...
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Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat
... Results: Intraperitoneally (IP) injection of AM251 before EPM trial decreased open arms exploration and open arm entry. On the other hand, Verapamil increased open arms exploration and open arm entry. Combined injection ...
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nanoPaint: dynamic imaging of nanoscopic structural plasticity of the plasma membrane
... AMPA receptor, which has an extracellular domain of 12 nm, showed that steric impairment hampers the accessibility and diffusion into the synaptic cleft for large QD- streptavidin nanoconstructs (>20 nm in ...
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
... the CB1 or CB2 receptor (Galiègue et ...of CB1 and CB2 protein and mRNA transcripts in human and animal kidney tissue as well as renal cell lines (Barutta et ...
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The effect of cannabinoids on IL 1beta induced catabolic pathways in osteoathritic chondrocytes
... and CB1 receptor agonist CP55,940 inhibited IL-1 p induced secretion of IL-6 and IL-8 in RA fibroblast like synovial cells, suggesting an anti-inflammatory activity of cannabinoids (Selvi et al, 2008) and ...
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Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
... of CB1 seemed to either increase or decrease adult neuro- genesis ...studies, CB1 receptor activation promoted precursor cell proliferation and the generation of neurospheres ex vivo, which was ...
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The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... Two experiments were conducted in this work. In the first exper- iment, the effect of acute IP administration of the CB1 recep- tor agonist WIN-55,212-2 (Cayman Chemical Company, MI, USA) on L-DOPA-treated rats ...
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Cannabis Sativa Revisited - Crosstalk between microRNAs Expression, Inflammation, Oxidative Stress and Endocannabinoid Response System in Critically Ill Patients with Sepsis
... the CB1 receptor and the central modulation mechanisms, one can obtain a significant increase in voluntary food ...of CB1 receptor agonists significantly increases ...the CB1 ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... of CB1 and CB2 receptor agonists. Second, the expression of the CB1 receptor was significantly increased in the urothe- lium and detrusor muscle in rats with BOO-associated DO, but no ...
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Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise
... sue CB1 and FAAH gene expression ...lowered CB1 and FAAH gene expression levels in gluteal, but not abdominal adipose tissue ...tissue CB1 protein expression and exercise training inhibited this ...
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