CCAAT/Enhancer Binding Protein alpha
A Protein Encoded by the Bovine Herpesvirus 1 Latency-Related Gene Interacts with Specific Cellular Regulatory Proteins, Including CCAAT Enhancer Binding Protein Alpha
... fusion protein. The LR fusion protein interacts with two proteins that can induce apoptosis (Bid and Cdc42) and with CCAAT enhancer binding protein alpha (C/EBP- ␣ ...
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The Herpesvirus Saimiri Replication and Transcription Activator Acts Synergistically with CCAAT Enhancer Binding Protein Alpha To Activate the DNA Polymerase Promoter
... Interestingly, although all these alternative REs confer ORF 50 responsiveness to a minimal heterologous promoter, the AT-rich RE contained in the ORF 50 and ORF 9 promoters may be less effective than the canonical ORF 6 ...
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CCAAT/enhancer Binding Protein-alpha (C/EBP-alpha) is a DNA-damage Inducible p53-regulated Mediator of the G1 Checkpoint.
... keratinocytes as well as in mouse skin in vivo. UVB irradiation of keratinocytes resulted in the transcriptional upregulation of C/EBPα mRNA producing >70 fold increase in C/EBPα protein. Treatment of ...
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CCAAT/Enhancer Binding Protein Alpha in UVB Responses in Human and Mouse Skin and Mouse Skin Tumorigenesis
... CCAAT/enhancer binding protein α (C/EBPα) is a DNA damage inducible p53 regulated gene in human and mouse keratinocytes and skin. Ultraviolet B radiation (UVB) is a potent inducer of C/EBPα in ...
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Transcription factor CCAAT/enhancer binding protein alpha up-regulates microRNA let-7a-1 in lung cancer cells by direct binding
... vitro binding assay shows that all of the four C/EBP elements and C/EBP consen- sus sequence have binding capacity with nuclear protein extracted from H1299 cells with ectopic C/EBPα expres- ...these ...
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British Journal of Medicine & Medical Research
... - CCAAT/enhancer-binding protein alpha; CTLA-4-cytotoxic T-lymphocyte-associated protein 4; DZ -dizygotic;FCRL3-Fc receptor-like protein 3; flCTLA-4- full-length CTLA-4; ...
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Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients
... Although both AD-MSCs derived from healthy and SSc SVFs contained a subpopulation positive for CD271, a putative adipose stem cell marker [20], the SSc AD- MSCs lacked the ability to differentiate into functional ...
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Anti adipogenic effects of the traditional herbal formula Dohongsamul tang in 3T3 L1 adipocytes
... acid binding protein 4 (FABP4) were purchased from Cell Signaling Technology ...USA), CCAAT/enhancer binding proteins alpha (C/EBPα) and β- actin were purchased from Santa Cruz ...
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TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice
... CHOP: CCAAT-enhancer-binding protein homologous protein; DMEM: Dulbecco ’ s modified Eagle ’ s medium; ELISA: Enzyme-linked immunosorbent assay; ER: Endoplasmic reticulum; FBS: Foetal ...
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The role of stromal cancer-associated fibroblasts in pancreatic cancer
... CHOP: CCAAT- enhancer-binding protein homologous protein; ECM: Extracellular matrix; EMT: Epithelial-mesenchymal transition; FAP: Fibroblast activation protein; FGF2: Fibroblast ...
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Biological roles of CCAAT/Enhancer-binding protein delta during inflammation
... leaky and mild elevation of proinflammatory mediators. Selectively removing the suppressive nuclear receptors, including peroxisome proliferator-activated receptor α and retinoic acid receptor, on the promoter regions of ...
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Molecular structure and transcriptional regulation of the gene for the platelet derived growth factor alpha receptor in cultured vascular smooth muscle cells
... the binding site for CCAAT/enhancer-binding proteins, and members of the C/enhancer-binding protein family play a significant role in the ...
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Transcription factors: Are they a real target for future therapeutic strategies?
... proximal binding of essential transcription factors to the TATA-box and their interaction with the RNA polymerase II and co-activators has been studied for several transcription factors their function as a ...
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C/EBP-alpha is an epithelial tumor suppressor gene, and mitogenic stimulation reciprocally regulates C/EBP-alpha and C/EBP-beta
... EGF-induced C/EBPβ phosphorylation, protein induction, and DNA binding are blocked by the MEK inhibitor U0126. Cells were treated as described above for figure 3A. Nuclear extracts were harvested 2 hours ...
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Docosahexaenoic acid increases accumulation of adipocyte triacylglycerol through up-regulation of lipogenic gene expression in pigs
... compared to the SBO- and DHA-fed pigs had increased lipolysis that was supported by similar effect in porcine ad- ipocytes treated with OA in vitro. Oleic acid inhibits the lipogenic gene expression, including C/EBP α ...
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Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation
... FOXO, CCAAT and SMAD binding sites [66, ...putative binding sites for the Upstream Stimulator Factor (USF), a regulator of cell cycle and proliferation, for RAS-Responsive element binding pro- ...
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Next-Generation Sequence Analysis of the Genome of RFHVMn, the Macaque Homolog of Kaposi's Sarcoma (KS)-Associated Herpesvirus, from a KS-Like Tumor of a Pig-Tailed Macaque
... A protein sequence and RF12 revealed N-terminal sequence homology with an interesting conserved motif CX(6)V PPSX(1,2)RGP [where X(6) means any 6 amino acids and X(1,2) means either 1 or 2 amino acids] ...
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Oligonucleotides targeting coagulation factor mRNAs: use in thrombosis and hemophilia research and therapy
... Although the mode of action of oligonucleotides in humans compared to current therapies can be regarded as a great benefit, it can be a problem in situations when rapid reversal of the silenced protein is ...
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CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis
... Array-based genomic hybridization is essential in searching for the key chromosomal regions harboring critical genes. In UC, chromosomal gains in 1q, 3p, 6p, 8q, 10p, 17q, and 20q are frequently identified [2, 3]. The ...
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Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis
... VDR binding sites by ChIP-seq identified that the majority of VDR binding sites did not have canonical VDR binding motifs, which consist of a direct repeat of two hexameric core binding motifs ...
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