CD, Cyclodextrin
Evaluation of the Cytotoxicity of Levodopa and its Complex with Hydroxypropyl--Cyclodextrin (HP--CD) to an Astrocyte Cell Line
... A simple, reliable a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxy-phenyl)-2-(4- sulfophenyl)-2H-tetrazolium, (MTS) assay was conducted to evaluate the potential cytotoxic effects of levodopa, a “gold standard ...
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Effect of Cyclodextrin Complexation on the Aqueous Solubility of Diazepam and Nitrazepam: Phase Solubility Analysis, Thermodynamic Properties
... Thermodynamic parameters derived from diazepam and nitrazepam solubility in the presence of various con- centrations of CDs at several temperatures revealed that the solubility of diazepam and nitrazepam increased pro- ...
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Influence of hydrophilic additives on the supersaturation and bioavailability of dutasteride-loaded hydroxypropyl- β-cyclodextrin nanostructures
... The animal experiments were approved by the Commit- tee on the Care and Use of Laboratory Animals at Inje University and performed according to the guidelines of the university. Male Sprague-Dawley rats (240–260 g) were ...
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INFLUENCE OF β-CYCLODEXTRIN COMPLEXATION ON KETOPROFEN RELEASE FROM MATRIX FORMULATION
... Phase solubility study (Inclusion complex of Ketoprofen) The solubility measurements of Ketoprofen with β- cyclodextrin were performed according to Higuchi and Connors T.A., 1965. Excess amounts of drug were added ...
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Journal of Applied Pharmaceutical Science
... Duloxetine hydrochloride (DXH) suffers from poor solubility and thereby poor absorption, which ultimately leads to poor bioavailability. In present study, an attempt has been made to formulate and characterize duloxetine ...
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Non-ionic thiolated cyclodextrins — the next generation
... thiolated cyclodextrin (CD) without ionizable groups and an intact ring backbone for drug ...beta CD (β-CD) was prepared through bromine substitution of its hydroxyl groups followed by ...
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Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo
... Therefore, cyclodextrin could be a useful delivery system for improving the bioavailability and therapeutic efficiency of EA and other poorly water- soluble drugs to treat piroplasmosis ...
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Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
... free cyclodextrin concentration was based on the amount of cyclodextrin present in the CD-EM complex at the indicated erythromycin ...of CD-EM complex. Therefore, 3.7 mg/mL of free ...
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ENHANCEMENT OF DISSOLUTION RATE OF EFAVIRENZ EMPLOYING β -CYCLODEXTRIN, POLOXAMER 407 AND PVP K 30: A FACTORIAL STUDY
... PVP K30 (2%) ternary complex (ac); efavirenz - Poloxamer 407 (2%) - PVP K30 (2%) ternary complex (bc) and efavirenz-βCD (1:2) - Poloxamer 407 (2%) - PVP K30 (2%) complex (abc). The CD complexes were prepared by ...
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Synergistic effect of methyljasmonate and cyclodextrin on stilbene biosynthesis pathway gene expression and resveratrol production in Monastrell grapevine cell cultures
... contrast, CD treated cell cultures showed a significant production of ...with CD and MeJA, the accumula- tion of resveratrol in the medium increased exponentially reaching a concentration plateau after 120 ...
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A promising antitumor activity of evodiamine incorporated in hydroxypropyl-β-cyclodextrin: pro-apoptotic activity in human hepatoma HepG2 cells
... In general, apoptotic cells display some specific morpho- logical and biochemical characteristics, including cell rounding and shrinkage, membrane blebbing, chromatin condensation [29], and mitochondrial inner membrane ...
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EFFECT OF SOLID DISPERSIONS, HP-β & γ- CYCLODEXTRIN INCLUSION COMPLEXES ON THE DISSOLUTION RATE OF SIMVASTATIN AND FORMULATION DEVELOPMENT & EVALUATION OF SIMVASTATIN ODTs
... and cyclodextrin inclusion complexes of drug are one of the promising ...HP-β CD inclusion complex and drug- γ CD inclusion complexes were prepared and evaluated for their efficiency in increasing ...
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Preparation and Characterization of Holmium Beta Cyclodextrin Complex
... Infrared spectroscopies were recorded on a Nicolet Magna-IR 550 FT-IR spectrometer (Madison, Wiscosin, USA), in the range of 400 - 4000 cm −1 . Samples of β -cyclodextrin, Holmium Nitrate pentahydrate, and Ho- β - ...
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Design of Safer Flame Retardant Textiles through Inclusion Complex Formation with Cyclodextrins: A Combined Experimental and Modeling Study.
... Triphenyl phosphate (TPP) is a phosphorus flame retardant that is widely applied all over the world. However it has recently attracted more and more attention due to a series of environmental and health issues, including ...
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Exploiting β cyclodextrin in molecular imprinting for achieving recognition of benzylparaben in aqueous media
... fragmentation chain transfer (RAFT) polymerization in the bulk polymerization process. RAFT polymerization was selected since it is versatile system and a promising method [22,23]. BzP analyte was selected as the ...
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Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation
... Abstract: Because of lower solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15 %. To get over this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask ...
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FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEX OF ACETYL SALICYLIC ACID (ASPIRIN) AND β CYCLODEXTRIN BY SOLVENT EVAPORATION & ITS COMPARATIVE STUDY TO ASPIRIN ALONE
... Β-CD was found to be soluble in Propylene Glycol (1 part of β-Cyclodextrin was found to be soluble in 175 parts of Propylene Glycol), in water at 30°C – Soluble (1 part in 40 parts of water). It was soluble ...
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Use of Baicalin Conjugated Gold Nanoparticles for Apoptotic Induction of Breast Cancer Cells
... Baicalin (BC) has been used for cancer therapy due to its multiple effects as an anti-cancer drug. However, the effective delivery of this molecule to targeted cells is difficult. Gold nanoparticles (AuNPs) conjugated ...
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The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
... Solution-stirring method was employed to prepare the Tol- HP- β -CD. In brief, Tol and HP- β -CD (mole ratio of 1:3) were weighed and added to 20% ( ω , v/v) aqueous acetonitrile. The pH of previous ...
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Enantioseparation of penconazole, myclobutanil and triadimefon by cyclodextrin-modified micellar electrokinetic chromatography
... by cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) under acidic condition was investigated with different HP-γ-CD concentrations as chiral ...
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