CD4+ T cell
The Cytomegalovirus-Specific CD4+ T-Cell Response Expands with Age and Markedly Alters the CD4+ T-Cell Repertoire
... CMV-specific CD4 T cells in elderly donors show impaired secretion of ...by CD4 T cells is important for promoting T-cell proliferation and can be used as a surrogate marker for ...
7
Cellular responses to Plasmodium falciparum erythrocyte membrane protein 1: use of relatively conserved synthetic peptide pools to determine CD4 T cell responses in malaria exposed individuals in Benin, West Africa
... require CD4 T cell help. CD4 T cells recognising conserved peptides of a malarial antigen would be potentially more beneficial in malaria immunity, as a memory response from such ...
8
Human CD4+ T Cell Response to Human Herpesvirus 6
... the CD4 ⴙ IFN-␥ response to ...HHV-6-specific CD4 ⫹ T cell response, we used a “bottom-up” peptide screening strategy ...HHV-6 T cell ...candidate T cell epitopes ...
17
Allogeneic Differences in the Dependence on CD4+ T-Cell Help for Virus-Specific CD8+ T-Cell Differentiation
... effector T cells during acute infection is believed not to require CD4 ⫹ T-cell help, with helper T cells instead being critical for generating and/or maintaining competent memory CD8 ⫹ ...
11
MyD88 Intrinsically Regulates CD4 T-Cell Responses
... affect T-cell responses? The current paradigm for explaining the regulation of T cells by MyD88 is that TLR-dependent activation of MyD88 in DCs leads to their maturation as APCs with the secretion ...
10
CD4 T cell activation by B cells in human Leishmania (Viannia)infection
... response. In the murine model of cutaneous leishmaniasis (CL) caused by L. major, IL-12 secretion by APCs is cru- cial for generation of IFN-γ-secreting Th1 cells, macro- phage activation and parasite elimination [3]. ...
13
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
... low CD4 ⫹ T cell count at set point was also found to correlate with the development of cross-neutralizing antibod- ...in CD4 ⫹ T cell count from preinfec- tion to 6 months ...
13
Supervised learning methods in modeling of CD4+ T cell heterogeneity
... CD4+ T cell differentiation model was built upon the current paradigms of mo- lecular interactions that occur in CD4+ T cells, which consists of 60 ODEs, 53 reactions, and 94 ...and ...
21
Quorum-Sensing in CD4+ T Cell Homeostasis: A Hypothesis and a Model
... naïve T cells, the trophic survival signals are contingent on TCR-mediated signals upon interactions with MHC Class-I or MHC Class-II molecules, and on γ c-dependent cytokines, namely IL-7 (Surh and Sprent, ...of ...
15
Comparison of capillary based microflurometric assay for CD4+ T cell count estimation with dual platform Flow cytometry
... The CD4 + T cell counts were estimated by dual platform Flow cytometry (FACSORT, BD 206, Becton Dickinson, USA) as a part of routine investigations using IMK Plus kit (Cat # 349217, BD, ...PE, ...
7
HIV Immunopathogenesis: Inhibition of CD4+ T Cell Activation
... antigen-stimulated CD4+ T cell ...human T regulatory cells (Treg) using an in vitro model ...of CD4+ T cell proliferation is independent of ...of CD4+ T ...
145
Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice
... 4. Belz, G. T., P. G. Stevenson, M. R. Castrucci, J. D. Altman, and P. C. Doherty. 2000. Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8⫹ T cells but confers ...
6
Particle-mediated DNA immunisation: CD4+ T cell priming and cooperation
... f T cells in back-signalling to DCs has been ...Activated T cells up-regulate CD40L and TRANCE, which bind to CD40 and RANK on DCs ...activated T cells promote the recruitment and effective ...
256
Identification of Cross-Reactive Norovirus CD4+ T Cell Epitopes
... documenting T cell responses following norovirus infection in humans or immunization in mice suggests that the cellular immune response is a poten- tially important component in norovirus vaccine ...both ...
9
CD4+ T-Cell Reconstitution Reduces Cytomegalovirus in the Immunocompromised Brain
... ⫹ T cells might play a pivotal role in combating CMV infection (19, ...⫹ T cells were the major effector cells against virus within the ...of T-cell subsets was done using negative selection ...
13
Original Article High CD4 T cell density is associated with poor prognosis in patients with non-muscle-invasive bladder cancer
... Odunsi T, Ritter G, Lele S, Chen YT, Ohtani H, Old LJ, Odunsi ...cd8+/regulatory T cell ratio are associated with favorable prognosis in ovarian ...
7
CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis
... reduce T-cell activation and proliferation by acting on transcription factors involved with production of IL-2, TNF-α, IFN-γ, IFNβ and granulocyte-macrophage colony stimulating ...of T and ...inhibit ...
92
Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults
... (FITC), CD4, CD8 conjugated to peridinin chlorophyll protein (Percp), CD45RA phycoerythrin (PE), CCR7 allophycocyanin (APC) (all from BD Bioscience, San Jose, CA), PD1-PE and Foxp3-PE (eBioscience, San Diego, ...
10
An atlas of mouse CD4+ T cell transcriptomes
... If splenic Tregs are similar to tTregs, whilst iTregs are more pTreg-like, then their SU genes will have appli- cation in distinguishing between these two cell types in vivo. This supposition is supported by the ...
25
The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis infected cattle
... of T cell development, making this a significantly enriched biological process in this dataset (P = ...in T cell differentiation (P = 6.75E-03) and 11 in T helper cell ...
15