CD40-B
Fas associated factor (Faf1) is a novel CD40 interactor that regulates CD40 induced NF κB activation via a negative feedback loop
... with CD40 via the TRAF6-binding domain of the ...to CD40 ligation is, at least in part, responsible for CD40- mediated NFkB activation, we propose that FAF1 regulates NFkB in the context of ...
10
Gene transfer of CD40 ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
... leukemic B cells, respec- ...for CD40 (CD154), a class II membrane glycoprotein (9–11, ...stimulate CD40-bearing B cells, monocytes, and dendritic cells into expressing other immune accessory ...
10
Bürger, Christina (2017): Cell type-specific CD40-CD40L interaction in atherosclerosis. Dissertation, LMU München: Medizinische Fakultät
... the CD40-CD40L axis 210 ...expressed CD40 ligand is then cleaved from the platelet over a period of minutes to hours subsequently generating sCD40L 226 ...to CD40-bearing vascular cells, ...
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Stojanovic, Kristina (2013): Die Rolle des NF-kappaB Signalwegs in LMP1/CD40-exprimierenden B-Zellen in vivo. Dissertation, LMU München: Fakultät für Biologie
... von CD40 wurde in Hodgkin Lymphomen und non-Hodgkin Lymphomen, chronisch lymphatischer Leukämie (CLL) (Kato et ...dass CD40 bei der Pathogenese der Tumoren beteiligt ...an CD40-Expression in ...
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Short circuiting long lived humoral immunity by the heightened engagement of CD40
... by CD40 agonists during TD immune responses. Tg B cells from recipients were purified on day 7 to 90% or more by magnetic bead selection using the congenic marker ...Tg B cells could be iso- lated ...
9
Comparative Analysis of Signal Transduction by CD40 and the Epstein-Barr Virus Oncoprotein LMP1 In Vivo
... responding B-cell population in re- sponse to blood infections, and their population is elevated in cases of autoimmune disorders ...of B-cell receptor signaling primarily control the development of MZ ...
9
Hömig, Cornelia (2005): Einfluss der Epstein-Barr-Virus Proteine LMP1 und EBNA2 auf die B-Zellentwicklung in vivo. Dissertation, LMU München: Fakultät für Biologie
... von B-Zellen wird durch die viralen Proteine LMP1 und EBNA2 ...der B-Zell-Differenzierung eine wichtige Rolle ...aktiven CD40 auf die B-Zellentwicklung zu untersuchen, um zu zeigen, in wieweit ...
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Expression of CD40 is a positive prognostic factor of diffuse large B-cell lymphoma treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)
... of the three tumor cores were finally averaged for each patient. A case was considered positive if 10% or more of the cells were stained with an antibody. Digital microscopy images were captured using an Olympus BX51 ...
7
The MS risk allele of CD40 is associated with reduced cell-membrane bound expression in antigen presenting cells: implications for gene function
... of CD40: B lymphocytes and ...of CD40 of all subsets analysed in published databases ...on CD40 expression in B-lymphocytes and monocytes freshly isolated from the peripheral blood of ...
14
Original Article Specific killing effect of cytotoxic T cells induced by OCT4 and Sox2 on lung adenocarcinoma stem cells
... Methods: CD40-activated B cells (CD40-B) were used as the antigen presenting cells (APCs) to induce the CSC-specific CTL with the peripheral lymphocytes of NSCLC patients, and the OCT4 and ...
6
Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
... functional CD40- 1C/T polymorphism ...of CD40 translations [11]. Although quan- titative differences between CD40 mRNA and proteins have been observed in SSc skin fibroblasts [10], the absence of ...
6
Establishment and Maintenance of Long-Term Murine Gammaherpesvirus 68 Latency in B Cells in the Absence of CD40
... of B-cell subsets; however, long-term EBV latency in the periphery resides almost exclusively in resting memory B cells (2, 3, 24, 28, ...long-lived B cells by appropriating control of normal ...
9
Preclinical Evaluation of CD40 Directed Immunotherapy in B Cell Lymphoma Using [18F]Fluorothymidine PET
... Formalin-fixed, paraffin-embedded sections (3 μm) of resected tumor tissue were dewaxed, rehydrated and processed according to standard procedures for immunohistochemistry. As primary antibody anti-CD40 (Acris ...
12
Latent Membrane Protein 1 as a molecular adjuvant for single cycle lentiviral vaccines
... primary B cells, including cell clumping; increased cell surface expression of CD23, CD39, CD40, CD44; decreased expression of CD10; and increased expression of the cell adhesion molecules CD11a (LFA1), ...
12
Requirement for CD40 Ligand, CD4+ T Cells, and B Cells in an Infectious Mononucleosis-Like Syndrome
... V4 T-cell receptor (TCR), are detected subsequent to im- mune control (17) of the initial, lytic infection in respiratory epithelium (7). The delay in onset of the IM-like disease sug- gests that the driving force is ...
5
Specific NEMO mutations impair CD40 mediated c Rel activation and B cell terminal differentiation
... patient B cells are character- ized by an absence of Ig somatic hypermutation (SHM) and defective class switch recombination (CSR) despite normal induction of activation-induced cytidine deaminase (AID) and Iε-Cε ...
11
Readministration of Adenovirus Vector in Nonhuman Primate Lungs by Blockade of CD40-CD40 Ligand Interactions
... Additional experiments were performed to determine wheth- er lack of T-cell priming in the absence of CD40L was due to inhibition of T-cell activation, anergy induction, or deletion of antigen-specific T cells. PBMC were ...
8
Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
... human B cells (44). Our results with normal B cells confirm those ...lupus B cells. Normal human B cells have to be coaxed by pharmacologic manipulations, such as a combination of calcium ...
12
Inhibition of IL-13 by Antisense Oligonucleotide Changes Immunoglobulin Isotype Profile in Cultured B-Lymphocytes
... Although there are several reports about antisense applications in different diseases such as cancer, there is no direct report on anti IL-13 antisense effects on antibody production [16, 17]. In search of molecules ...
7
The role of novel risk markers in cardiovascular disease
... In summary, the conventional risk factors o f blood pressure, cholesterol and smoking are well established as causal factors for CVD. Effective and safe treatments are available for these risk factors and CVD can be ...
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