CDK1/Cyclin B1
Human Papillomavirus Type 16 E1∧E4-Induced G2 Arrest Is Associated with Cytoplasmic Retention of Active Cdk1/Cyclin B1 Complexes
... of Cdk1/cyclin B1. Since the Cdk1/cyclin B1 enzyme complex in 16E1 ∧ E4-expressing cells appears to be active, why is entry into mitosis prevented? Analysis by immunofluorescence ...
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Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions
... and B1 occurs along with the induction of cyclin-dependent kinase (CDK) ...specific CDK1 inhibitor blocked VZV spread, indicating an important function for this cellular kinase in VZV ...with ...
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<p>MiR-153-5p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Paclitaxel by Inducing G2M Phase Arrest</p>
... the CDK1/cyclin B complex is synthesized ...the CDK1/cyclin B complex was able to induce G2/M phase cell cycle ...Meanwhile, CDK1 also has been reported to affect the PI3K/Akt pathway, ...
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DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway
... of Cdk1/cyclin B1 complex, also called maturation-promoting factor (MPF) ...[11]. Cyclin B1, the positive regulator of Cdk1/Cdc2 kinase, is upregulated during G2 phase due to the ...
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Mitotic p21 Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
... inhibiting Cdk1 activity with the Cdk1 inhibitor RO-3306 or by adding back wild type p21 ...fine-tuning Cdk1 activity. Cdk1/cyclin B1 controls various key steps in early mitosis ...
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Original Article Downregulation of Cited1 suppresses cell proliferation by inducing G2/M arrest of the cell cycle in non-small-cell lung cancer cell lines
... of CDK1 [28-30]. The activity of CDK1 is dependent upon binding of cyclin B ...the CDK1/cyclin B complex is sustained by phosphorylation of CDC25C, which is considered as a rate-limit- ...
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<p>Se-Enriched <em>Cordyceps militaris</em> Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells</p>
... cells. Cyclin B1 and CDK1 are G2/M cell cycle regulatory ...of cyclin B1 and CDK1 were obtained in NCI-H292 and A549 cells with Se-enriched Cordyceps ...
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<p>Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma</p>
... Results: MYBL2 expression was significantly higher in ESCC tissue when compared to the adjacent normal tissue (P=0.007). MYBL2 was found to be positively correlated with Ki67 (γ=0.286, P=0.003). Furthermore, Kaplan–Meier ...
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Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer
... against CDK1, 2, 5, and 9 (IC 50 1-4nM), but with less activity against CDK4, 6, and 7 (IC50 60-100nM), showed encouraging anti-tumor effect in preclinical studies of TNBC with potential ...
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The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
... cyclin B1, which was upregulated 5-fold in Fzr1 / oocytes compared with control oocytes, appeared critically regulated by ...regulating cyclin B1 has also been observed in neurons (Almeida ...
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Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection
... clin B1 and its encoding RNA, which precludes cyclin B1/CDK1 complex function, thus preventing mitotic ...of cyclin B1 RNA was not affected by MVM infection, the production of ...
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Propranolol Decreases Proliferation of Endothelial Cells Transformed by Kaposi's Sarcoma-Associated Herpesvirus and Induces Lytic Viral Gene Expression
... the CDK1 and CDK2 inhibitor roscovitine demonstrated reduced numbers of KSHV-infected cells (solid line) (P ⫽ ...of CDK1 and CDK2 as well as their binding partners cyclins A2 (CycA2), B1 (CycB1), and ...
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The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review
... the cyclin B1/CDK1 complex and promote the growth of the corre- sponding tumor, and there is a correlation between sur- vival and proliferation ...
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Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer
... GSK-3 β inhibitors may inhibit cell proliferation through modulating cyclin-dependent kinases (CDKs). CDKs bind to cyclins, forming complexes that have protein kinase activ- ity, promoting cell cycle phase ...
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Nagel, Susanna (2008): Initial Characterization of two novel spindle proteins, CHICA and HURP: Focus on the role of the Ran-importin β-regulated HURP protein in kinetochore-fiber stabilization.. Dissertation, LMU München: Fakultät für Biologie
... the Cyclin-dependent kinase, Cdk1 (Nigg, 2001). While Cdk1 protein levels are constant throughout the cell cycle, its activity is tightly regulated by phosphorylation and protein-protein ...of ...
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Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1
... – Cdk1, Cdk2, Cdk4, and Cdk6 and their cyclin regulators [22, ...that Cdk1 can bind cyclin E and substitute for Cdk2 during the G1/S phase transition ...that Cdk1 binds all cyclins and ...
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Identification of core genes in ovarian cancer by an integrative meta-analysis
... G2/mitotic-specific cyclin-B2; CDC20: Cell-division cycle protein 2; CDK1: Cyclin-dependent kinase 1; CENPA: Centromere protein A; DEGs: Differentially expressed genes; EGA: The European ...
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<p>New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity</p>
... (cyclin B1, cyclin D1, and phos- phorylated cyclin-dependent kinase 1), and a pro-apoptotic protein (Bcl-2-associated X protein gene), and activated ...
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Characterization of the Sak kinase interaction with cyclin B1 and Gadd45a
... Polo-like Kinases Function and Members 1 The Structure of the Polo-like Kinases 2 Plks Expression and Kinase Activity 4.. Plks Localization 5.[r] ...
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Cyclin B2/cyclin dependent kinase1 dissociation precedes CDK1 Thr 161 dephosphorylation upon M phase promoting factor inactivation in Xenopus laevis cell free extract
... total cyclin B2 pool and the CDK1- associated one, we immunoprecipitated pro- teins present in samples obtained during the experiment similar to the one shown in ...and cyclin B2 degradation) with ...
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