Cecal ligation and puncture (CLP)
Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats
... of cecal ligation and puncture (CLP)-induced sepsis syndrome, this study tested the hypotheses that: (1) CLP-induced sepsis syndrome may significantly con- tribute to ALI and AKI; (2) ...
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Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat
... The SD rats were initially housed three per cage in a temperature (18–22 °C) and humidity-controlled room under a constant 12-h light/dark cycle and fed with standard rat chow and water ad libitum. After acclima- ...
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Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?
... a cecal ligation and puncture (CLP) murine model of sepsis, due to a decrease in both chemokine release and platelet-leukocyte interac- tions ...the CLP mouse model, thereby aiding in ...
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Role of the IL-33-ST2 axis in sepsis
... of cecal ligation and puncture (CLP)-induced sepsis, ST2 deletion leads to improved survival and more efficient bacterial clearance in mice challenged with secondary pneumonia ...to ...
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Plasmadiafiltration ameliorating gut mucosal barrier dysfunction and improving survival in porcine sepsis models
... by cecal ligation and puncture (CLP) operation were randomly divided into three groups: PDF group, high-volume hemofiltration (HVHF) group, and control group, and received 8 h treatment, ...
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Increased plasma levels of endozepines, endogenous ligands of benzodiazepine receptors, during systemic inflammation: a prospective observational study
... Sepsis was induced by cecal ligation and puncture (CLP) as previously described [18]. Rats were anesthetized with ketamine (80 mg/kg) and xylazine (10 mg/kg). A 2-cm midline incision was made; ...
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The role of receptor for advanced glycation endproducts (RAGE) in infection
... including cecal ligation and puncture (CLP)-induced abdominal sepsis [9], diabetic nephro- pathy, delayed type hypersensitivity, type II collagen induced arthritis, hepatic injury, and ...
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Western diet enhances hepatic inflammation in mice exposed to cecal ligation and puncture
... to cecal ligation and puncture (CLP) to induce sepsis as described previously ...third). Cecal contents were manually extruded and spread with a sterile cotton ...without ...
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Expanded endothelial progenitor cells mitigate lung injury in septic mice
... BALB/c mice (8–10 weeks old, n = 169) were used. Sepsis was induced by cecal ligation and puncture (CLP) on day 0 [3]. Briefly, animals were anesthetized with sevoflurane and a midline ...
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Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin.
... of cecal ligation and puncture (CLP) in rodents (3, 35), which resembles the clinical situation of bowel perforation and mixed bacterial infection of intestinal origin, is a more realistic ...
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Human Ghrelin Ameliorates Organ Injury and Improves Survival after Radiation Injury Combined with Severe Sepsis
... by cecal ligation and puncture (CLP), and ghrelin administration decreases inflammatory responses, improves organ blood flow, attenuates tissue injury, and reduces mortality under such ...
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Critical illness induces nutrient independent adipogenesis and accumulation of alternatively activated tissue macrophages
... a cecal ligation and puncture (CLP)-fed mouse (B), Proliferating Cell Nuclear Antigen (PCNA) gene expression (C), percentage stained area for peroxisome proliferator-activated receptor g ...
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Mechanism of the inhibitory effect of ghrelin in sepsis
... Abstract: Sepsis and septic shock are the leading causes of death in intensive care units. Approxi- mately 40%–70% of the mortality is associated with severe sepsis and septic shock. Systemic antibiotic usage, surgical ...
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Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture
... the CLP model, the pro-inflammatory response is delayed and persists over time ...the CLP model, mortality is delayed with multiple organ failure complicating induced ...The CLP model is the most ...
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Kinetics and protective role of autophagy in a mouse cecal ligation and puncture induced sepsis
... To further confirm the completion of autophagy, we examined liver samples by transmission electron micros- copy. The autolysosome, which has a single limiting membrane and contains cytoplasmic/organellar mate- rials at ...
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Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis
... our CLP model, which should be considered when interpreting the results of our study in the context of other variations to the CLP ...our CLP model in a 24-h study period, we extruded varying amounts ...
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Anti vascular endothelial growth factor antibody attenuates inflammation and decreases mortality in an experimental model of severe sepsis
... kit-8; CLP: cecal ligation and puncture; CX3CL1: C-X3-C motif ligand 1; FBS: fetal bovine serum; HUVECs: human umbilical vein endothelial cells; ICAM-1: intercellular adhesion molecule 1; IL- ...
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Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture
... to CLP (in this study, the context was to determine if a pre-existing trauma ampli- fies subsequent CLP ...to CLP (Figure 3) (as opposed to many other markers of endothelial dysfunction that were ...
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Use of Tat-Hsp70 Fusion Protein to Attenuate Sepsis-Induced Lung Injury in Rodents With Acute Respiratory Distress Syndrome Caused by Cecal Ligation and Double Puncture (2clp)
... to CLP sepsis-induced ARDS, exhibiting increased lung injury, increased activation and prolonged binding/activation of NF-κB in lung tissue, increased expression of TNF−α and IL-6, and increased ...
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Original Article Protective effects of curcumin on hepatocytes in cecal ligation and puncture-induced sepsis in rats
... the CLP-induced hepatocyte edema and inflammation indicators, especially in the Xuebijing and 100-mg/kg curcumin ...with CLP. Curcumin has a protective effect on CLP-induced liver dysfunction and ...
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